Abstract

  Coronaviruses belong to the Family Coronaviridae, which is a classification of enveloped virus pathogens that have a large positive RNA genome. Coronaviruses are known to cause a variety of debilitating ailments including gastroenteritis and diseases of the lower/upper respiratory track. Coronaviruses are known to infect bats, cats, camels, chickens, cows, dogs, ferrets, horses, mice, minks, pigs, rabbits, raccoons, rats, snakes, tigers, and turkeys. To date, at least seven known human coronaviruses exist including: HCoV-229E, HCoV-OC43, HCoV-HKU1, HCoV-NL63, MERS-COV, SARS-CoV and the most recently discovered, SARS-COV-2, also known as COVID-19. This manuscript is intended to identify the health concerns and molecular identification methods for all known human coronaviruses in order to combat the spread of SARS-COV-2.

Keywords: Coronavirus; SARS-COV-2; COVID-19; Virus; Virology; Public Health; Molecular Biology

References

1. Abroug Fekri., et al. "Family cluster of Middle East respiratory syndrome coronavirus infections, Tunisia, 2013”. Emerging Infectious Diseases9 (2014): 1527.
2. Alanazi Khalid H., et al. "Diabetes Mellitus, Hypertension, and Death among 32 Patients with MERS-CoV Infection, Saudi Arabia”. Emerging Infectious Diseases1 (2020): 166.
3. Al-Tawfiq, Jaffar A. "Asymptomatic coronavirus infection: MERS-CoV and SARS-CoV-2 (COVID-19)". Travel Medicine and Infectious Disease (2020).
4. Arnold Forest W., et al. "Endemic Human Coronaviruses in Hospitalized Adults with Community-Acquired Pneumonia: Results from the Louisville Pneumonia Study”. Journal of Respiratory Infections1 (2020): 1.
5. Ashour Hossam M., et al. "Insights into the recent 2019 novel Coronavirus (SARS-CoV-2) in light of past human coronavirus outbreaks”. Pathogens 3 (2020): 186.
6. Bonilla-Aldana D Katterine., et al. “MERS-CoV and SARS-CoV Infections in Animals: A Systematic Review and Meta-Analysis of Prevalence Studies”. Preprints (2020).
7. Chan Jasper Fuk-Woo., et al. "Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan”. Emerging Microbes and Infections1 (2020): 221-236.
8. Corman Victor., et al. "Detection of a novel human coronavirus by real-time reverse-transcription polymerase chain reaction”. Eurosurveillance39 (2012).
9. Corman Victor M., et al. "Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR." Eurosurveillance 25.3 (2020): 20285.
10. De Wit Emmie., et al. "Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection”. Proceedings of the National Academy of Sciences12 (2020): 6771-6776.
11. Drosten Christian., et al. "Identification of a novel coronavirus in patients with severe acute respiratory syndrome”. New England Journal of Medicine20 (2003): 1967-1976.
12. Kampf, G., et al. “Persistence of coronaviruses on inanimate surfaces and its inactivation with biocidal agents”. Journal of Hospital Infection (2020).
13. Khot Wasim Yunus and Milind Y Nadkar. "The 2019 Novel Coronavirus Outbreak-A Global Threat”. The Journal of the Association of Physicians of India 3 (2020): 67-71.
14. Ko Meehyun., et al. "Screening of FDA-approved drugs using a MERS-CoV clinical isolate from South Korea identifies potential therapeutic options for COVID-19”. Bio Rxiv (2020).
15. Kissler S., et al. Projecting the transmission dynamics of SARS-CoV-2 through the post-pandemic period (2020).
16. Li Xiang., et al. "Bat origin of a new human coronavirus: there and back again”. Science China Life Sciences3 (2020): 461-462.
17. Lorusso Alessio., et al. "Novel coronavirus (SARS-CoV-2) epidemic: a veterinary perspective”. Veterinaria Italiana (2020).
18. Meo SA., et al. "Novel coronavirus 2019-nCoV: prevalence, biological and clinical characteristics comparison with SARS-CoV and MERS-CoV”. European Review for Medical and Pharmacological Sciences 24 (2020): 2012-2019.
19. Nilsson Anna., et al. "Fatal encephalitis associated with coronavirus OC43 in an immunocompromised child”. Infectious Diseases (2020): 1-4.
20. Niu Junwei., et al. "Non-invasive bioluminescence imaging of HCoV-OC43 infection and therapy in the central nervous system of live mice”. Antiviral Research 173 (2020): 104646.
21. Noh Jin-Won., et al. "Effect of Information Disclosure Policy on Control of Infectious Disease: MERS-CoV Outbreak in South Korea”. International Journal of Environmental Research and Public Health 1 (2020): 305.
22. Pan Yang., et al. "Viral load of SARS-CoV-2 in clinical samples”. The Lancet Infectious Diseases4 (2020): 411-412.
23. Paraskevis Dimitrios., et al. "Full-genome evolutionary analysis of the novel corona virus (2019-nCoV) rejects the hypothesis of emergence as a result of a recent recombination event”. Infection, Genetics and Evolution 79 (2020): 104212.
24. Phan Tung. "Novel coronavirus: From discovery to clinical diagnostics”. Infection, Genetics and Evolution 79 (2020): 104211.
25. Pérez Cecilia Perret and Marcela Ferrés Garrido. "Pneumonia Caused by Emerging Viral Agents”. Pediatric Respiratory Diseases (2020): 335-341.
26. Pfefferle Susanne., et al. "Distant relatives of severe acute respiratory syndrome coronavirus and close relatives of human coronavirus 229E in bats, Ghana”. Emerging Infectious Diseases9 (2009): 1377.
27. Raj V Stalin., et al. "Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC”. Nature7440 (2013): 251-254.
28. Rasheed Muhammad Asif., et al. In Silico Identification of Novel B Cell and T Cell Epitopes of Wuhan Coronavirus (2019-nCoV) for Effective Multi Epitope-Based Peptide Vaccine Production (2020).
29. Sheahan Timothy P., et al. "Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV”. Nature Communications1 (2020): 1-14.
30. Sloots Theo P., et al. "Evidence of human coronavirus HKU1 and human bocavirus in Australian children”. Journal of Clinical Virology1 (2006): 99-102.
31. Stephensen Charles B., et al. "Phylogenetic analysis of a highly conserved region of the polymerase gene from 11 coronaviruses and development of a consensus polymerase chain reaction assay”. Virus Research2 (1999): 181-189.
32. Thiel Volker., et al. "Infectious RNA transcribed in vitro from a cDNA copy of the human coronavirus genome cloned in vaccinia virus”. Journal of General Virology6 (2001): 1273-1281.
33. Tsai Yu-Chi., et al. "Antiviral Action of Tryptanthrin Isolated from Strobilanthes cusia Leaf against Human Coronavirus NL63”. Biomolecules 3 (2020): 366.
34. Van der Hoek Lia., et al. "Identification of a new human coronavirus”. Nature Medicine4 (2004): 368-373.
35. Villamil-Gómez, Wilmer E., et al. "Fatal human coronavirus 229E (HCoV-229E) and RSV-Related pneumonia in an AIDS patient from Colombia”. Travel medicine and infectious disease (2020): 101573.
36. Wang, Lin-Fa., et al. "From Hendra to Wuhan: what has been learned in responding to emerging zoonotic viruses”. The Lancet10224 (2020): e33-e34.
37. Wang, Yanqun., et al. "Discovery of a subgenotype of human coronavirus NL63 associated with severe lower respiratory tract infection in China, 2018”. Emerging Microbes and Infections1 (2020): 246-255.
38. World Health Organization. “Laboratory testing for coronavirus disease 2019 (COVID-19) in suspected human cases: interim guidance 2020.”. World Health Organization (2020).
39. Xu Xintian., et al. "Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission”. Science China Life Sciences3 (2020): 457-460.
40. Zhang Jiahao., et al. "The continuous evolution and dissemination of 2019 novel human coronavirus”. Journal of Infection (2020): 30083-30089.
41. Zhang Lu., et al. "Complete Genome Sequences of Five Human Coronavirus NL63 Strains Causing Respiratory Illness in Hospitalized Children in China”. Microbiology Resource Announcements8 (2020).
42. Zhou Yadi., et al. "Network-based Drug Repurposing for Human Coronavirus”. Med Rxiv (2020).

Citation

Citation: Jonathan Daniel Hulse. “Human Coronaviruses: The Deadly Seven". Acta Scientific Microbiology 3.6 (2020): 86-89.

Copyright

Copyright: © 2020 Jonathan Daniel Hulse. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.