Abstract

  Chikungunya virus (CHIKV) is a deadly Arbovirus that is transmitted to humans by the mosquito species Aedes aegypti. Infection is often associated with fever, headache, muscle pain, joint swelling, or rash. In the present study, the identification of selective inhibitors against Chikungunya virus is reported. The compounds considered were found to be inhibitors of DENGUE virus. The compounds were screened and their inhibitory activity was investigated using in-silico molecular docking study. Overall a total of 13 compounds were studied using molecular docking approach. The in-silico study of such selective inhibitors will contribute to a better understanding of the CHIKV replication cycle and also represent a step towards the development of a clinical candidate drug for the treatment of this disease.

Keywords: CHIKV; Molecular Docking; Phytochemicals

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Citation

Citation: Danish I Jasnaik and Basilin Benson. “Computational Docking Studies of Non-Structural Protein 2 Protease of Chikungunya with Phytochemicals". Acta Scientific Microbiology 3.6 (2020): 80-85.

Copyright

Copyright: © 2020 Danish I Jasnaik and Basilin Benson. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.