Abstract

  Experiments on random-bred albino mice showed that α7n-acetylcholine receptors (α7nAChRs) agonist (GTS-21) and STAT3 inhibitor (S3I - 201) lead to the realization of the cholinergic anti-inflammatory pathway (the reduce the mortality of mice, the blood concentrations of proinflammatory cytokines TNF-α, IL-1β and IL-6 in sepsis (intraperitoneal of 2.5×10⁹ CFUs diurnal culture of E. coli). The combined action of α7nAChRs agonist and STAT3 inhibitor causes an additive effect.

Keywords: Cholinergic Anti-Inflammatory Pathway; Proinflammatory Cytokines; Sepsis; Α7n-Acetylcholine Receptors; STAT3 Inhibitor

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Citation

Citation: Pavel Franzevich Zabrodskii. “The Realization of the Cholinergic Anti-Inflammatory Pathway Under the Influence of α7nAChRs Agonist and STAT3 Inhibitor in Sepsis". Acta Scientific Microbiology 3.3 (2020): 01-05.

Copyright

Copyright: © 2020 Pavel Franzevich Zabrodskii. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.