Acta Scientific Microbiology (ASMI) (ISSN: 2581-3226)

Research Article Volume 3 Issue 3

The Realization of the Cholinergic Anti-Inflammatory Pathway Under the Influence of α7nAChRs Agonist and STAT3 Inhibitor in Sepsis

Pavel Franzevich Zabrodskii*

Saratov Medical University "REAVIZ", Saratov, Russian Federation

*Corresponding Author: Pavel Franzevich Zabrodskii, Saratov Medical University "REAVIZ", Saratov, Russian Federation.

Received: January 17, 2020; Published: February 26, 2020

×

Abstract

  Experiments on random-bred albino mice showed that α7n-acetylcholine receptors (α7nAChRs) agonist (GTS-21) and STAT3 inhibitor (S3I - 201) lead to the realization of the cholinergic anti-inflammatory pathway (the reduce the mortality of mice, the blood concentrations of proinflammatory cytokines TNF-α, IL-1β and IL-6 in sepsis (intraperitoneal of 2.5×109 CFUs diurnal culture of E. coli). The combined action of α7nAChRs agonist and STAT3 inhibitor causes an additive effect.

Keywords: Cholinergic Anti-Inflammatory Pathway; Proinflammatory Cytokines; Sepsis; Α7n-Acetylcholine Receptors; STAT3 Inhibitor

×

References

  1. Byrne L and Van Haren F. “Fluid resuscitation in human sepsis: Time to rewrite history?” Annals of Intensive Care 7.1 (2017): 4.
  2. Zabrodskii PF., et al. “Role of β2-adrenoreceptors in adrenergic anti-Inflammatory mechanism in sepsis”. Bulletin of Experimental Biology and Medicine 162.12 (2016): 718-721.
  3. Martin GS. “Sepsis, severe sepsis and septic shock: changes in incidence, pathogens and outcomes”. Expert Review of Anti-infective Therapy 10.6 (2012): 701-706.
  4. Lin JN., et al. “Risk factors for mortality of bacteremic patients in the emergency department”. Academic Emergency Medicine 16 (2009): 749-755.
  5. Zabrodskii PF. “Effect of armin on nonspecific resistance factors of the body and on the primary humoral immune response”. Farmakologiia I Toksikologiia 50.1 (1987): 57-60. 
  6. Zabrodskii PF. “Variation in antiinfectious nonspecific resistance of the organism caused by cholinergic stimulation”. Bulletin of Experimental Biology and Medicine 120.2 (1995): 809-811.
  7. Zabrodskii PF. “Change in the non-specific anti-infection resistance of the body exposed to cholinergic stimulation”. Bulletin of Experimental Biology and Medicine 120.8 (1995): 164-166.
  8. PF Zabrodskii. “Immunotoxicology of organophosphorus compounds”. Saratov (2016): 289.
  9. Borovikova LV., et al. “Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin”. Nature 405.6785 (2000): 458-462.
  10. Gallowitsch-Puerta M and Pavlov VA. “Neuro-immune interactions via the cholinergic anti-inflammatory pathway”. Life Sciences 80.24-25 (2007): 2325-2329.
  11. Pavlov VA., et al. “The cholinergic anti-inflammatory pathway: a missing link in neuroimmunomodulation”. Molecular Medicine 9.5-8 (2003): 125-134.
  12. Wang H., et al. “Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation”. Nature 421.6921 (2003): 384-388.
  13. Zabrodskii PF., et al. “Combined Effects of M1 Muscarinic Acetylcholine Receptor Agonist TBPB and α7n-Acetylcholine Receptor Activator GTS-21 on Mouse Mortality and Blood Concentration of Proinflammatory Cytokines in Sepsis”. Bulletin of Experimental Biology and Medicine 162.6 (2017): 750-753.
  14. Zabrodskii PF., et al. “Combined Effect of NF-κB Inhibitor and β2-Adrenoreceptor Agonist on Mouse Mortality and Blood Concentration of Proinflammatory Cytokines in Sepsis”. Bulletin of Experimental Biology and Medicine 162.6 (2018): 445-448.
  15. Zabrodskii PF., et al. “Effect of α7n-acetylcholine receptor activation and antibodies to TNF-α on mortality of mice and concentration of proinflammatory cytokines during early stage of sepsis”. Bulletin of Experimental Biology and Medicine 159.6 (2015): 740-742.
  16. Wang Z., et al. “The STAT3 inhibitor S3I-201 suppresses fibrogenesis and angiogenesis in liver fibrosis”. Laboratory Investigation (2018): 11.
  17. Zila I., et al. “Vagal-immune interactions involved in cholinergic anti-inflammatory pathway”. Physiological Research 66.2 (2017): S139- S145. 
  18. Park JW., et al. “Inhibition of STAT3 activity delays obesity-induced thyroid carcinogenesis in a mouse model”. Endocrine-Related Cancer 23.1 (2016): 53-63.
  19. Zhao J., et al. “Protective effect of suppressing STAT3 activity in LPS-induced acute lung injury”. American Journal of Physiology-Lung Cellular and Molecular Physiology 311.5 (2016): L868-L880.
  20. Song DJ., et al. “Effect of lentiviral vector encoding on triggering receptor expressed on myeloid cells 1 on expression of inflammatory cytokine in septic mice infected by Bacteroides fragilis”. Zhonghua Shao Shang Za Zhi 25.1 (2009): 36-41. 
  21. Zabrodskii PF and Mandych VG. “Immunotoxicology of xenobiotics”. Saratov Military Institute of Biological and Chemical Safety (2007): 420.
  22. Norman GJ., et al. “Cardiopulmonary arrest and resuscitation disrupts cholinergic anti-inflammatory processes: a role for cholinergic α7 nicotinic receptors”. Journal of Neuroscience 31.9 (2011): 3446-3452.
  23. Abraham E. “Nuclear factor-kappaB and its role in sepsis-associated organ failure”. Journal of Infectious Diseases 187.2 (2003): 364-369.
×

Citation

Citation: Pavel Franzevich Zabrodskii. “The Realization of the Cholinergic Anti-Inflammatory Pathway Under the Influence of α7nAChRs Agonist and STAT3 Inhibitor in Sepsis". Acta Scientific Microbiology 3.3 (2020): 01-05.



Member In






News and Events


  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is July 15, 2020.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of “Best Article of the Issue”.
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.
  • Contact US