Acta Scientific Microbiology (ASMI) (ISSN: 2581-3226)

Short Report Volume 3 Issue 2

Antibacterial, Antifungal, Antimycetoma Activities of Nigella Sativa

JK Oberoi* and Tooba Momin

Department of Microbiology, Abeda Inamdar Senior College B, K. B. Hidayatullah Road, Azam Campus, Pune, India

*Corresponding Author: JK Oberoi, Department of Microbiology, Abeda Inamdar Senior College B, K. B. Hidayatullah Road, Azam Campus, Pune, India.

Received: December 13, 2019; Published: January 08, 2019

×

Abstract

  There are many medicinal plants which are having therapeutic potentials. Nigella sativa, commonly known as ‘Kalonji’ or ‘black cumin’ is a herbaceous plant which grows in Mediterranean countries but has been cultivated into other parts of the world. In the religion of Islam, it is considered as the greatest forms of healing medicine available. Prophet Muhammad (Peace be upon him) once stated that the Kalonji (Nigella sativa) can treat every disease -- except death (Sahih Bukhari 71:592). There are many biological activities of Nigella sativa which are reported in recent years including antioxidant, anti-inflammatory, anticancer and antibacterial, anti-diabetic, antifungal and many more. Plethora of studies have been carried out by researchers by using different seed extracts from Nigella sativa for antibacterial, antifungal, anti-mycetoma activities. Madurella mycetomatis is the commonest causative organism causing Eumycetoma and Streptomyces somaliensis is the commonest organism causing actinomycetoma [2]. In general, the current treatment for mycetoma is expensive and unsatisfactory. It needs a long duration, and has many side effects [3]. If drugs not effective and bone is infected, amputate the limb or debride tissue and continue treatment up to years.

  The present review is an effort to provide a detailed survey of the literature on scientific researches of anti-bacterial, anti-fungal and anti-mycetoma activities of the chloroform, ethanol and methanol extracts of Nigella sativa seed in vitro against bacterial strains of Staphylococcus Aureus, Proteus Vulgaris, Escherichia coli. , Fungal strains of Candida albicans, Aspergillus flavus and the organism Madurella mycetomatis of mycetoma.

Keywords: Nigella Sativa; Black Cumin; Kalonji; Mycetoma

×

References

  1. Ahmad A., et al. “A review on therapeutic potential of Nigella sativa: A miracle herb”. Asian Pacific Journal of Tropical Biomedicine 3.5 (2013): 337-352.
  2. Fahal AH.  “Review Mycetoma”. Khartoum Medical Journal 04.01 (2011): 514-523.
  3. Mahgoub ES and SA Gumaa. “Ketoconazole in the treatment of eumycetoma due to Madurella mycetomii”. Transactions of the Royal Society of Tropical Medicine and Hygiene 78 (1984): 376-379.
  4. Redgrave H stanly. Spices and Condiments, Pitman and sans (1933).
  5. Topozada, H.H., et al. “The anti-bacterial properties of Nigella sativa seeds: active principle with some clinical application”. The Journal of the Egyptian Medical Association 48 (1965): 187-202.
  6. El-Fatatry HM. “Isolation and structure assignment of an antimicrobial principle from the volatile oil of Nigella sativa L. seeds”. Pharmazie 30.2 (1975): 109-111.
  7. Hanafi MS and Hatem ME. “Studies on the anti-microbial activity of the Nigella sativa seed (Black Cumin)”. Journal of Ethnopharmacology 34.2-3 (1991): 275-278.
  8. Rafati S., et al. “Anti-microbial effect of Nigella sativa seed extract against staphylococcal skin infection”. Medical Journal of The Islamic Republic of Iran 8.28 (2014): 42.
  9. Morsi NM. “Antimicrobial effect of crude extracts of Nigella sativa on multiple antibiotic resistant bacteria”. Acta Microbiologica Polonica 49.1 (2000): 63-74.
  10. Mashhadian NV and Rakhshandeh H. “Antibacterial and antifungal effects of Nigella sativa extracts against S. aureus, P. aeruginosa and C. albicans”. Pakistan Journal of Medical Sciences 21.1 (2005): 47-52.
  11. Salman MT., et al. “Antimicrobial activity of Nigella sativa oil against Staphylococcus aureus obtained from clinical specimens”. In: 38th Annual Conference of Indian Pharmacological Society, Chennai, India (2005): 28-30.
  12. Khan MA., et al. “The in vivo antifungal activity of the aqueous extract from Nigella sativa seed”. Phytotherapy Research 17 (2003): 183-186.
  13. Al-Jabre S., et al. “Thymoquinone, an active principle of Nigella sativa, inhibited Aspergillus niger”. Pakistan Journal of Medical Research 42 (2003): 102-104.
  14. Alqorashi A., et al. “The effect of thymoquinone and B on the growth of Aspergillus niger”. Scientific Journal of King Faisal University 8.1 (2007): 137-145.
  15. Aljabre SHM., et al. “Antidermatophyte activity of ether extract of Nigella sativa and its active principle, thymoquinone”. Journal of Ethnopharmacology 101 (2005): 116-119.
  16. Kader HAA., et al. “In vitro study of the effect of some medicinal plants on the growth of some dermatophytes”. Assiut Veterinary Medical Journal 34.6-7 (1995): 36-42.
  17. Taha M., et al. “Antifungal effect of thymol, thymoquinone and thymohydroquinone against yeasts, dermatophytes and non-dermatophyte molds isolated from skin and nails fungal infections”. Egyptian Journal of Biochemistry and Molecular Biology 28.2 (2010): 109-126.
  18. Elfadil H., et al. “The in vitro antifungal activity of sudanese medicinal plants against Madurella mycetomatis, the mycetoma major causative agent”. PLOS Neglected Tropical Diseases 9.3 (2015):  e0003488. 
  19. Eduard EZ and Fahal AH. Mycetoma: a unique neglected tropical disease 16.1 (2016): 100-112. 
×

Citation

Citation: JK Oberoi and Tooba Momin. “Antibacterial, Antifungal, Antimycetoma Activities of Nigella Sativa". Acta Scientific Microbiology 3.2 (2020): 23-27.




Metrics

Acceptance rate30%
Acceptance to publication20-30 days

Indexed In






News and Events


  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is December 25, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"

Contact US