Charles H Williams
The Williams Research Laboratory, Sunrise Beach, Mo USA
*Corresponding Author: Charles H Williams, The Williams Research Laboratory, Sunrise Beach, Mo USA.
Received: December 16, 2019; Published: January 06, 2020
Malignant Hyperthermia is inherited as a dominant gene in pigs and in humans. It is characterized by a rapidly increasing body temperature up to 118oF with a metabolic rate over 10x normal, an intense peripheral vasoconstriction with blood pressures over 400 mmHg, and a fatal outcome in most cases.
The MH syndrome is triggered by exercise, hauling to market, breeding activity, hot weather, and other stress factors. In humans, the cases are triggered by depolarizing muscle relaxants, Halothane anesthesia, and other halogenated anesthesia compounds. Non-depolarizing muscle relaxants such as Pancuronium and Vecuronium are safer to use. Organon 9426 (Rocuronium) is safe to use and provides carry over protection against the development of MH.
Keywords: Sixth Nerve Palsy; Chikungunya Virus Infection
Citation: Charles H Williams. “A Review: Malignant Hyperthermia-A Genetic Disease of Sodium Channel Function". Acta Scientific Microbiology 3.2 (2020): 12.
Copyright: © 2020 Charles H Williams. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.