Acta Scientific Microbiology (ASMI) (ISSN: 2581-3226)

Case Report Volume 3 Issue 2

A Review: Malignant Hyperthermia-A Genetic Disease of Sodium Channel Function

Charles H Williams

The Williams Research Laboratory, Sunrise Beach, Mo USA

*Corresponding Author: Charles H Williams, The Williams Research Laboratory, Sunrise Beach, Mo USA.

Received: December 16, 2019; Published: January 06, 2020


  Malignant Hyperthermia is inherited as a dominant gene in pigs and in humans. It is characterized by a rapidly increasing body temperature up to 118oF with a metabolic rate over 10x normal, an intense peripheral vasoconstriction with blood pressures over 400 mmHg, and a fatal outcome in most cases.

  The MH syndrome is triggered by exercise, hauling to market, breeding activity, hot weather, and other stress factors. In humans, the cases are triggered by depolarizing muscle relaxants, Halothane anesthesia, and other halogenated anesthesia compounds. Non-depolarizing muscle relaxants such as Pancuronium and Vecuronium are safer to use. Organon 9426 (Rocuronium) is safe to use and provides carry over protection against the development of MH.

Keywords: Sixth Nerve Palsy; Chikungunya Virus Infection



  1. Williams CH and Lasley JF. “The mode of inheritance of the fulminant hyperthermia-porcine stress syndrome in swine”. In: Proceedings of the Focus on Malignant Hyperthermia Symposium, Wausau, Wisconsin, 13 September 1974, edited by E O Henschel, New York: Appleton Century Crofts (1977): 141-148.
  2. Williams, CH in ABB 5 (2014): 3.
  3. Williams, CH in OJMIP 5 (2015): 2.
  4. Williams, CH, Hoech GP, Zukaitis, MG in ABB 5 (2014): 5.
  5. Charles H Williams. "Malignant Hyperthermia: The Spontaneous development of the MH-PSS Syndrome". Medical & Clinical Research Journal 1.2 (2017): 01-04.
  6. Charles H Williams. "The Development of Lethal MH-PSS with the Secondary Development of an Intense Peripheral Vasoconstriction a Review". Acta Scientific Microbiology 2.4 (2019): 118-121.


Citation: Charles H Williams. “A Review: Malignant Hyperthermia-A Genetic Disease of Sodium Channel Function". Acta Scientific Microbiology 3.2 (2020): 12.


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