Acta Scientific Microbiology (ISSN: 2581-3226)

Research Article Volume 3 Issue 1

The Influence of Nitrile Acrylate Acute Intoxication on the Stem Cell Migration from Bone Marrow to Spleen and the Parameters of Innate and Adaptive Immunity

Pavel Franzevich Zabrodskii*

Saratov Medical University "REAVIZ", Saratov, Russia

*Corresponding Author: Pavel Franzevich Zabrodskii, Saratov Medical University "REAVIZ", Saratov, Russia.

Received: November 11, 2019; Published: December 11, 2019



   Experiments on random-bred albino mice and rats showed that nitrile acrylate acute intoxication (0.25 and 0.75 LD50) dose-dependent reduces the integral state of the organism's anti-infection nonspecific resistance (innate immunity) due to suppression of bactericidal activity of blood serum, serum concentrations of lysozyme, platelet cationic protein, functional activity of neutrophils, increased the mortality rate of mice in comparison with the control and CFUs of opportunistic flora in peripheral blood and spleen. The action of nitrile acrylate in direct dose dependence reduces the stem cell migration from bone marrow to spleen and the basic parameters of innate and adaptive immunity.

Keywords: Nitrile Acrylate; Immunotoxicity; Stem Cell Migration; Innate Immunity; Adaptive Immunity; E. Coli



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Citation: Pavel Franzevich Zabrodskii. "The Influence of Nitrile Acrylate Acute Intoxication on the Stem Cell Migration from Bone Marrow to Spleen and the Parameters of Innate and Adaptive Immunity".Acta Scientific Microbiology 3.1 (2020): 80-83.


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