Acta Scientific Microbiology (ISSN: 2581-3226)

Short Communication Volume 3 Issue 1

IL-23/Th17 Cell Axis and Psoriasis

Shirin Tarafder*

Professor, Microbiology and Immunology Department, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh, South Asia

*Corresponding Author: Shirin Tarafder, Professor, Microbiology and Immunology Department, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh, South Asia.

Received: November 21, 2019; Published: December 09, 2019

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  Psoriasis is an immune mediated inflammatory skin disease caused by a complex interplay between the immune system, Psoriasis-associated susceptibility loci, Psoriasis autoantigens and multiple environmental factors. Over the last two decades, researches has unequivocally shown that Psoriasis represents a T-cell mediated disease primarily driven by pathogenic T-cells that produce high levels of IL- 17 in response to IL- 23. The activation and upregulation of IL- 17 in pre-psoriatic skin produces a feed forward inflammatory response in keratinocytes that is self-amplifying and drives the development of mature psoriatic plaques by inducing epidermal hyperplasia, epidermal cell proliferation and the recruitment of leukocyte subsets into the skin. The discovery of the central role for the IL- 23/Th17 cell axis in the development of Psoriasis has led to a major paradigm shift in the pathogenic model for this condition [1,2].

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Citation

Citation: Shirin Tarafder . “IL-23/Th17 Cell Axis and Psoriasis".Acta Scientific Microbiology 3.1 (2020): 48-49.



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