Wemambu II*, Ajose DJ and Eni CC and Suliman M Hussein
Department of Biological Sciences, College of Natural and Applied Sciences, Bells University of Technology, Ota, Ogun State, Nigeria
*Corresponding Author: Wemambu II, Department of Biological Sciences, College of Natural and Applied Sciences, Bells University of Technology, Ota, Ogun State, Nigeria.
Received: April 14, 2018; Published: June 05, 2018
Citation: Wemambu II., et al. "Antibacterial Effect of Carica papaya Root Extract on Some Selected Pathogens from Clinical Isolates" Acta Scientific Microbiology 1.7 (2018).
Introduction: The search for alternate sources of antibiotics to combat the growing global challenge of antibiotic resistance is imperative thus this study was designed to determine the antibacterial activity of Carica papaya root extract on Klebsiella species, Escherichia coli, Salmonella species, Pseudomonas species and Staphylococcus aureus.
Materials and Method: Dried and pulverized papaya roots were mixed with extraction solvents (water and ethanol). Aseptically the extracts were filtered and inoculated into Nutrient agar to ascertain sterility of the solutions.
Results: Results showed high antibacterial activity for ethanol extract and the cold-water extract of Carica papaya with ethanol extract having more effect. It was observed that the extract was effective against the Gram- positive and Gram-negative test organisms investigated while the Antibiotic susceptibility test revealed that the microorganisms were resistant to one or two of the antibiotics used (Ceftazidime (30 μg), Cefuroxime (30 μg), Gentamicin (10 μg), Ciprofloxacin (5 μg), Augmentin (50 μg), Nitrofurantoin (300 μg), Oflaxacin (5 μg), Ampicillin (10 μg) except for Escherichia coli which was resistant to all antibiotics used.
Conclusion:From the results obtained in this study, it can be inferred that Carica papaya root part is a potential source of natural therapeutic option that can be further exploited for the treatment of bacterial infection.
Keywords: Carica papaya; Antibacterial; Pathogenic Bacterial Isolates; Extracts
Copyright: © 2018 Wemambu Ifeoma Irene., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.