The Influence of Various Drags on Mortality of Mice and the Concentration of
Proinflammatory Cytokines in Blood at Sepsis Caused by
Pavel Franzevich Zabrodskii*
Saratov Medical University “REAVIZ”, Saratov, Russia
*Corresponding Author: Pavel Franzevich Zabrodskii, Saratov Medical University “REAVIZ”, Saratov, Russia.
February 22, 2018; Published: April 09, 2018
Experiments on albino mice showed that administration m-cholinomimetic (aceclydine), n-cholinomimetic (nicotine), reversible
inhibitor of acetylcholinesterase (neostigmine methyl sulfate), n-cholinomimetic α7nAChRs agonist (GTS-21), epinephrine hydro-
chloride, adrenomimetic β2ARs agonist (hexoprenaline sulfate) causes decrease in mice mortality in sepsis caused by the adminis
tration (i.p.) of
O157:H7 and the concentration of TNF-α, IL-1β and IL-6 in the blood in comparison with parameters at sepsis
without use of drugs.
Keywords: Sepsis; Cytokines; E. coli; Cholinergic Drugs; Adrenergic Drugs
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