Acta Scientific Microbiology

Research ArticleVolume 1 Issue 5

The Influence of Various Drags on Mortality of Mice and the Concentration of Proinflammatory Cytokines in Blood at Sepsis Caused by E. coli

Pavel Franzevich Zabrodskii*

Saratov Medical University “REAVIZ”, Saratov, Russia

*Corresponding Author: Pavel Franzevich Zabrodskii, Saratov Medical University “REAVIZ”, Saratov, Russia.

Received: February 22, 2018; Published: April 09, 2018

DOI: 10.31080/ASMI.2018.01.0046

Citation: Pavel Franzevich Zabrodskii. “The Influence of Various Drags on Mortality of Mice and the Concentration of Proinflammatory Cytokines in Blood at Sepsis Caused by E. coli ”. Acta Scientific Microbiology 1.5 (2018).


  Experiments on albino mice showed that administration m-cholinomimetic (aceclydine), n-cholinomimetic (nicotine), reversible inhibitor of acetylcholinesterase (neostigmine methyl sulfate), n-cholinomimetic α7nAChRs agonist (GTS-21), epinephrine hydro- chloride, adrenomimetic β2ARs agonist (hexoprenaline sulfate) causes decrease in mice mortality in sepsis caused by the adminis - tration (i.p.) of E. coli O157:H7 and the concentration of TNF-α, IL-1β and IL-6 in the blood in comparison with parameters at sepsis without use of drugs.

Keywords: Sepsis; Cytokines; E. coli; Cholinergic Drugs; Adrenergic Drugs


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Copyright: © 2018 Paul Njenga Waithaka., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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