Acta Scientific Gastrointestinal Disorders (ISSN: 2582-1091)

Editorial Volume 3 Issue 2

The Challenge of Evaluation of Gastrointestinal Symptoms in HIV Patients

Stefani Panayiotou*

Department of Gastroenterology and Hepatology, University of Cyprus, Athens, Greece

*Corresponding Author: Stefani Panayiotou, Department of Gastroenterology and Hepatology, University of Cyprus, Athens, Greece.

Received: November 26, 2019; Published: January 01, 2020

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  HIV disease is a frequent infection, whose number of individuals living with it worldwide exceeds 37 million [1]. Among the lots of complications which it causes are gastrointestinal and hepatobiliary disorders [2]. More than 50% of all HIV patients had reported gastrointestinal (GI) symptoms during their disease [3,4].

  HIV and gastrointestinal system appears to have a relation. The gastrointestinal tract has a primary role in pathogenesis of HIV infection [5]. Studies have shown that GI system is a main site of HIV replication and CD4 T-cell death [6]. During the infection there is considerable reduction of CD4 T-cells within the gut-associated lymphoid tissue (GALT) [7].

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References

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  4. Gazzard BG. “HIV disease and the gastroenterologist”. Gut 29 (1988): 1497-1505.
  5. Knox TA., et al. “Diarrhea and abnormalities of gastrointestinal function in a cohort of men and women with HIV infection”. The American Journal of Gastroenterology 95 (2000): 3482-3489.
  6. Nannini EC and Okhuysen PC. “HIV1 and the gut in the era of highly active antiretroviral therapy”. Current Gastroenterology Reports 4 (2002): 392-398.
  7. Veazey RS., et al. “Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection”. Science 280 (1998): 427-431.
  8. Wilcox CM., et al. “AGA Technical Review: Malnutrition and cachexia, chronic diarrhea, and hepatobiliary disease in patients with human immunodeficiency virus infection”. Gastroenterology 111 (1996): 1724-1752.
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  16. Maresca M., et al. “The virotoxin model of HIV-1 enteropathy: involvement of GPR15/Bob and galactosylceramide in the cytopathic effects induced by HIV-1 gp120 in the HT-29-D4 intestinal cell line”. Journal of Biomedical Science 10 (2003): 156-166.
  17. Schmitz H., et al. “Supernatants of HIV-infected immune cells affect the barrier function of human HT-29/B6 intestinal epithelial cells”. AIDS 16 (2002): 983-991.
  18. Ulrich R., et al. “Enteric immunologic abnormalities in human immunodeficiency virus infection”. Seminar on Liver Disease 12 (1992): 167-174.
  19. Riecken EO., et al. “Non-opportunistic causes of diarrhoea in HIV infection”. In: Gazzard BG, ed. Bailliere's Clinical Gastroenterology. London: Balliere-Tindall 4 (1990): 385-403.
  20. Foucar E., et al. “Colon ulceration in lethal cytomegalovirus infection”. American Journal of Clinical Pathology 76 (1981): 788-801.
  21. Meiselman MS., et al. “Cytomegalovirus colitis: Report of the clinical, endoscopic and pathologic findings in two patients with acquired immunodeficiency syndrome”. Gastroenterology 88 (1985): 171-175.
  22. Eras P., et al. “Candida infection of the gastrointestinal tract”. Medicine 51 (1972): 367-379.
  23. Cello JP and Wilcox CM. “Evaluation and treatment of gastrointestinal tract hemorrhage in patients with AIDS”. Gastroenterology Clinics of North America 17 (1988): 639-648.
  24. Kotler DP., et al. “Effect of combination antiretroviral therapy upon rectal mucosal HIV RNA burden and mononuclear cell apoptosis”. AIDS 12 (1998): 597-604.
  25. He M., et al. “Prospective observation for seven-year’s highly active antiretroviral therapy in Chinese HIV-1 Infected patients”. Current HIV Research 9 (2011): 160-165.
  26. Wallace MR and Brann OS. “Gastrointestinal manifestations of HIV infection”. Current Gastroenterology Reports 2 (2000): 283-293.
  27. Tadesse WT., et al. “Self-reported adverse drug reactions and their influence on highly active antiretroviral therapy in HIV-infected patients: a cross-sectional study”. BMC Pharmacology and Toxicology 15 (2014): 32.
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Citation

Citation: Stefani Panayiotou. "The Challenge of Evaluation of Gastrointestinal Symptoms in HIV Patients".Acta Scientific Gastrointestinal Disorders 4.2 (2020): 01-03.



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