Aleksandrov MT*

Professor, Department of Dentistry, FUV GBUZ MO, Moscow Regional Research Clinical Institute, Russia

*Corresponding Author: Abhishek Kumar Pandey, Senior Resident, Department of Dentistry, Kalyan Singh Super Speciality Cancer Institute, Lucknow, (U.P)., India.

Received: July 31, 2026; Published: August 28, 2026

The aim of the study was to evaluate the diagnostic efficacy of a multimodal biophotometric system (MBS) in various dental pathologies, considering the impact of oxidative stress and psychoemotional strain.

Materials and Methods: A prospective, controlled, singlecenter study included 279 patients divided into 4 groups: control (n = 30), initial pathology manifestations (n = 57), pronounced forms (n = 171), and exacerbation of chronic diseases (n = 21). The methods included multimodal biophotometry (405 nm excitation, 400–700 nm spectral range), clinical index assessment, and saliva analysis (cortisol via ELISA, perceived stress via PSS10 scale).

Results: MBS demonstrated high diagnostic accuracy: sensitivity 93.6 %, specificity 94.6 %, and AUC 0.941, indicating excellent model quality. The greatest diagnostic gain was observed for leukoplakia (AUC 0.961) and gingivitis (AUC 0.940). Fluorescent indices (mucoproteins), (porphyrins), and their ratio proved to be informative markers of oxidative stress, hyposalivation, and microbial load.

Conclusions: MBS provides an objective, personalized assessment of dental status, surpasses traditional methods in diagnostic accuracy, and is suitable for monitoring treatment efficacy.

Keywords: Multimodal Biophotometry; Oxidative Stress; Dental Status; Fluorescence Diagnostics;, Personalized Medicine

References

1. Alexandrov MT. “Laser Clinical Biophotometry: Theory, Experiment, Practice”. Moscow: Technosphera; (2008): 584.
2. Alexandrov MT., et al. “Raman fluorescence characteristics of dental hard tissues and their clinical significance”. Russian Journal of Dentistry 1 (2018): 4-11.
3. Alexandrov MT and Utyuzh AS. “Laser Raman Fluorescence Medical Technologies in Dentistry: From Experiment to Clinical Practice”. Moscow: KnigIzdat (2020): 384.
4. Alexandrov MT., et al. “Assessment of dental hard tissue mineralization by Raman fluorescence medical technologies under the influence of various physical and chemical factors in healthy patients and in patients with carious and noncarious lesions”. Russian Journal of Dentistry6 (2023): 521-531.
5. Ahmed S., et al. “Markers of oxidative stress as a tool for diagnosing oral cancer and precancerous conditions: a systematic review”. Journal of Dental Research Dental Clinics Dental Prospects3 (2025): 139-145.
6. Tóthová L., et al. “Salivary markers of oxidative stress in oral diseases”. Frontiers in Cellular and Infection Microbiology 5 (2015): 73.
7. A method for assessing oxidative stress in metabolic syndrome.
8. VONA R., et al. “Biomarkers of Oxidative Stress in Metabolic Syndrome and Associated Diseases”. Oxidative Medicine and Cellular Longevity (2019).
9. Kibkalo AP., et al. “Level of Oxidative Stress Markers in Generalized Periodontitis on the Background of Bronchiectasis”. Kuban Scientific Medical Bulletin5 (2019): 42-51.
10. Aleksandrov MT., et al. “Substantiation of the use of digital methods for assessing the dental status of the oral cavity in normal and pathological conditions”. Russian Journal of Dentistry4 (2023): 301-310.
11. World Health Organization. “Oral health surveys: basic methods”. 5^th Geneva: WHO (2013).
12. Hosmer DW, Lemeshow S. “Applied logistic regression”. 3^rd Hoboken: Wiley (2013).
13. Salimetrics LLC. “Salivary cortisol ELISA kit manual”. State College: Salimetrics (2020).
14. Cohen Patel R and Williams K. “Fluorescence spectroscopy in oral diagnostics: principles and applications”. Journal of Oral Medicine and Dental Research 12 (3) (2021): 45-58.
15. Al Jawad M., et al. “Raman spectroscopy for the noninvasive assessment of oral mucosal health and disease”. Journal of Biophotonics11 (2019): e201900132.
16. Alexandrov MT. “Principles of multimodal biophotometry in dental diagnostics”. In: Advanced Optical Methods in Dentistry. Moscow: MedPress (2020): 89-112.
17. Cohen S. “Biophotometric approaches to personalized oral assessment: from research to practice”. Journal of Research in Medical and Dental Science1 (2023): 12-25.

Citation

Citation: Aleksandrov MT. “Additive Effect of Stress Factors on Dental Status: A Comprehensive Analysis of Relationships (Literature Review)". Acta Scientific Dental Sciences 10.9 (2026): 39-49.

Copyright

Copyright: © 2026 Aleksandrov MT. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.