Acta Scientific Dental Sciences

Review Article Volume 10 Issue 9

Platelet Concentrates as Biofunctional Coatings for Dental Implants: A Mini-Review

Azza Abokhaled Ahmed1, Doaa Adel-Khattab1*, Eman Fathy2 and Yasmine Ahmed Fouad1

1Department of Oral Medicine, Periodontology and Oral Diagnosis, Faculty of Dentistry, Ain Shams University, Cairo, Egypt
2Department of Oral Biology, Faculty of Dentistry, Ain Shams University, Cairo, Egypt

*Corresponding Author: Doaa Adel-Khattab, Associate Professor of Oral Medicine, Periodontology and Oral Diagnosis, Faculty of Dentistry, Ain Shams Uni- versity, Egypt.

Received: July 27, 2026; Published: August 14, 2026


The long-term success of dental implants depends not only on osseointegration but also on the establishment of a stable and healthy peri-implant soft tissue seal. Titanium is the most commonly used implant material, but biological and aesthetic limitations have led to the search for alternatives. Zirconia provides metal-free esthetics but with mechanical risks. Polyetheretherketone (PEEK) has emerged as a promising candidate due to its bone-like elastic modulus. However, the biological inertness of PEEK results in limited protein adsorption, cellular attachment, and tissue integration. Hence, surface modification strategies are required. Autologous platelet concentrates have attracted increasing attention as a biofunctional surface coating due to their sustained release of growth factors such as TGF-β, PDGF, and VEGF, which are known to induce gingival fibroblast proliferation, collagen synthesis, and soft tissue repair. This mini review aims to provide an overview of the current evidence regarding dental implant materials, implant surface modification strategies, and the potential role of platelet concentrates as a biofunctional coating for improving the biological performance of dental implants. The results indicate that platelet concentrates may represent a promising strategy to improve cellular responses and tissue healing around implant surfaces.

Keywords: Dental Implants; Platelet Concentrates; PRP; Gingival Fibroblasts

References

  1. Branemark PI. “Osseointegration and its experimental background”. Journal of Prosthetic Dentistry3 (1983): 399-410.
  2. Jin S., et al. “Surface modification strategies to reinforce the soft tissue seal at transmucosal region of dental implants”. Bioactive Material 42 (2024): 404-32.
  3. Wennerberg A and Albrektsson T. “Effects of titanium surface topography on bone integration: a systematic review”. Clinical Oral Implants Researchs4 (2009): 172-184.
  4. Buser D., et al. “Modern implant dentistry based on osseointegration: 50 years of progress, current trends and open questions”. Periodontology 20001 (2017): 7-21.
  5. Hong DGK and Oh J hyeon. “Recent advances in dental implants”. Maxillofacial Plastic and Reconstructive Surgery. Springer (2017).
  6. Barberi J and Spriano S. “Titanium and Protein Adsorption: An Overview of Mechanisms and Effects of Surface Features”. Materials 7 (2021): 1590.
  7. Mangal M., et al. “Metal ion release of titanium and titanium alloy dental implants with dissimilar abutment materials: A systematic review of in vitro studies”. Journal of Indian Society of Periodontology 3 (2025).
  8. Romanos G., et al. “Titanium Wear of Dental Implants from Placement, under Loading and Maintenance Protocols”. International Journal of Molecular Sciences3 (2021): 1067.
  9. Furlanetto M., et al. “Titanium Particle Impact on Immune Cells, Cytokines, and Inflammasomes: Helping to Profile Peri-Implantitis—A Systematic Review”. Oral4 (2025): 80.
  10. Wang T., et al. “Changes in the esthetic, physical, and biological properties of a titanium alloy abutment treated by anodic oxidation”. Journal of Prosthetic Dentistry1 (2019): 156-165.
  11. Mohseni P., et al. “Clinical outcomes of zirconia implants: a systematic review and meta-analysis”. Clinical Oral Investigation1 (2023): 15.
  12. Aldhuwayhi S. “Zirconia in Dental Implantology: A Review of the Literature with Recent Updates”. Bioengineering 5 (2025): 543.
  13. Wiedemann T. “Zirconia Implants: An Emerging Revolution in Implantology”. Clinical Research and Clinical Case Reports 6 (2023): 1-6.
  14. Tang K., et al. “The integration of peri-implant soft tissues around zirconia abutments: Challenges and strategies”. Bioactive Material 27 (2023): 348-361.
  15. Tian J., et al. “Influence of Different Surface Treatments on the Low-Temperature Degradation of Three Commercial Yttria-Stabilized Tetragonal Zirconia Polycrystal”. Materials 11 (2025): 2543.
  16. Zhang F., et al. “Fracture analysis of one/two-piece clinically failed zirconia dental implants”. Dental Materials10 (2022): 1633-1647.
  17. Morena D., et al. “Comparative Clinical Behavior of Zirconia versus Titanium Dental Implants: A Systematic Review and Meta-Analysis of Randomized Controlled Trials”. Journal of Clinical Medicine15 (2024): 4488.
  18. Polat Sağsöz N., et al. “CF-PEEK vs. Titanium Dental Implants: Stress Distribution and Fatigue Performance in Variable Bone Qualities”. Biomimetics9 (2025): 619.
  19. Cheng YH., et al. “Unveiling the characteristics and surface modification of titanium, zirconia, and polyetheretherketone dental implants”. Journal of Dental Sciences. Association for Dental Sciences of the Republic of China (2025): 2046-2057.
  20. Dondani JR., et al. “Surface Treatments of PEEK for Osseointegration to Bone”. Biomolecules MDPI (2023).
  21. Pandey C., et al. “Contemporary Concepts in Osseointegration of Dental Implants: A Review”. Biomed Research International1 (2022).
  22. Jambhulkar N., et al. “Surface modification techniques for different materials used in dental implants review”. Material Today Proceeding 60 (2022): 2266-2269.
  23. Hadzik J., et al. “An Experimental Anodized Titanium Surface for Transgingival Dental Implant Elements—Preliminary Report”. Journal of Functional Biomaterial1 (2023): 34.
  24. Acerra A., et al. “PRF and PRP in Dentistry: An Umbrella Review”. Journal of Clinical Medicine. Multidisciplinary Digital Publishing Institute (MDPI); (2025).
  25. Shi X., et al. “PRP coating on different modified surfaces promoting the osteointegration of polyetheretherketone implant”. Frontiers in Bioengineering and Biotechnology 11 (2023).
  26. Ivanovski S., et al. “Impact of autologous platelet concentrates on the osseointegration of dental implants”. Periodontology 2000. John Wiley and Sons Inc (2025): 271-286.
  27. Miron RJ., et al. “Injectable platelet rich fibrin (i-PRF): opportunities in regenerative dentistry?” Clinical Oral Investigation8 (2017): 2619-27.
  28. Jia K., et al. “Platelet-rich fibrin as an autologous biomaterial for bone regeneration: mechanisms, applications, optimization”. Frontiers in Bioengineering and Biotechnology 12 (2024).
  29. Smith PC., et al. “Role of Fibroblast Populations in Periodontal Wound Healing and Tissue Remodeling. Frontiers in Physiology”. Frontiers Media S.A (2019).
  30. Peng Y., et al. “Gingival mesenchymal stem cells: Biological properties and therapeutic applications". Journal of Oral Biology and Craniofacial Research 14 (5 (2024): 547-569.
  31. Kim D., et al. “Gingiva-Derived Mesenchymal Stem Cells: Potential Application in Tissue Engineering and Regenerative Medicine - A Comprehensive Review”. Frontiers in Immunology 12-2021 (2021).
  32. Iozon S., et al. “Injectable platelet-rich fibrin influences the behavior of gingival mesenchymal stem cells”. Romanian Journal of Morphology and Embryology1 (2020): 189-198.

Citation

Citation: Doaa Adel-Khattab., et al. “Platelet Concentrates as Biofunctional Coatings for Dental Implants: A Mini-Review". Acta Scientific Dental Sciences 10.9 (2026): 17-20.

Copyright

Copyright: © 2026 Doaa Adel-Khattab., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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