Relevance of Oral Microbiome – A Narrative Review
Chandrasekharan Nair K 1 *, Hemalatha Konka2 , Viswanath
Gurumurthy3 , Pradeep C Dathan4 , Lovely M Annamma5 , D
Bheemalingeswara Rao 6 and T Mohan Kumar
1 Professor Emeritus, Department of Prosthodontics, Sri Sankara Dental College, Akathumuri, Thiruvananthapuram, Kerala, India
2 Registrar Prosthodontist, Al Harkan Dental Hospital, Al Qassim, Saudi Arabia
3 Associate Professor, Department of Dental Technology, College of Applied Medical Sciences, King Khalid University, KSA
4 Professor and Head of the Department of Prosthodontics, Sri Sankara Dental College, Akathumuri, Thiruvananthapuram, Kerala, India
5 Visiting Faculty, Department of Clinical Sciences, College of Dentistry, Ajman, United Arab Emirates
6 Professor and Head of the Department of Prosthodontics, Vishnu Dental College, Bhimavaram, AP, India
7 Director, Centre for Temporomandibular Disorders, Kunnukuzhi, Trivandrum, Kerala, India
*Corresponding Author: Chandrasekharan Nair K, Professor Emeritus, Department
of Prosthodontics, Sri Sankara Dental College, Akathumuri, Thiruvananthapuram,
Kerala, India.
Received:
December 30, 2025; Published: January 31, 2026
Abstract
Microbial community of the oral cavity is considered as complex, second only to the gut microbiome. Oral cavity is exposed
to inhaled and ingested microbes that consist of more than 700 species of bacteria, fungi, viruses, archaea and protozoa. Oral
microbiome composition differs with individuals and with the micro habitat. However, the principal function of the microbiome
remains similar in every individual. The commensal microbiome maintains oral and systemic health with delicate balance. If the
balance or equilibrium is altered, both oral and systemic diseases can be developed. This is an attempt to give a narrative review on
the basics of oral microbiome
Keywords: Oral Microbiome; Oral Microbiota; Oral Diseases; Systemic Diseases; Microbial Dysbiosis; Probiotics; Oral Care; Bio Film
References
- Dobell C. “Antony van Leeuwenhoek and His ‘Little Animals’: Being Some Account of the Father of Protozoology and Bacteriology and His Multifarious Discoveries in these Disciplines”. (Harcourt, Brace and Company, (1932).
- Mukherjee C., et al. “Acquisition of oral microbiota is driven by environment, not host genetics”. Microbiome 9 (2021): 54.
- Sulyanto RM., et al. “The predominant oral microbiota is acquired early in an organized pattern”. Scientific Report 9 (2019): 10550.
- Lederberg J and A T Mccray. “Ome sweet ’omics—a genealogical treasury of words”. Scientist 15 (2001): 8-10
- Backhed F., et al. “Defining a healthy human gut microbiome: current concepts, future directions, and clinical applications”. Cell Host Microbe5 (2012): 611-622.
- Lim Y., et al. “Oral microbiome: A New biomarker reservoir for oral and oropharyngeal cancers”. Theranostics 7 (2017): 4313‑43
- , et al. “Defining the oral microbiome by whole genome sequencing and resistome analysis: the complexity of the healthy picture”. BMC Microbiology 20 (2020): 120.
- Deo PN and Deshmukh R. “Oral microbiome: Unveiling the fundamentals”. Journal of Oral Maxillofacial Pathology 23 (2019): 122-128.
- Kaan AMM., et al. “Acquisition and establishment of the oral microbiota”. Periodontology 2000 86 (2021): 123-141.
- Arianna K DeGruttola., et al. “Current understanding of dysbiosis in disease in human and animal models”. Inflammatory Bowel Disease 22 (2016): 1137-1150.
- Kerr AR. “The oral microbiome and cancer”. Journal of Dental Hygiene1 (2015): 20-23.
- Beck JD and Offenbacher S. “Systemic effects of periodontitis: epidemiology of periodontal disease and cardiovascular disease”. Journal of Periodontology 76 (2005): 2089-2100.
- Gillings M R., et al. “Ecology and evolution of the human microbiota: Fire, farming and antibiotics”. Genes (Basel) 6 (2015): 841-857.
- American Dental Association. “History of Dentistry Timeline”. (2016).
- Pedersen A., et al. “The role of natural salivary defences in maintaining a healthy oral microbiota”. Journal of Dentistry 80 (2019): S3-S12.
- Cross BW and Ruhl S. “Glycan recognition at the saliva - oral microbiome interface”. Cellular Immunology 333 (2018): 19-33.
- Marsh P D., et al. “Influence of saliva on the oral microbiota”. Periodontology 20001 (2016): 80-92.
- Blostein F., et al. “Associations Between Salivary Bacteriome Diversity and Salivary Human Herpesvirus Detection in Early Childhood: A Prospective Cohort Study”. Journal of the Pediatric Infectious Diseases Society 8 (2021): 856-863.
- Li X., et al. “The oral microbiota: community composition, influencing factors, pathogenesis”. D - 101548977. (- 1664-302X (Print)): - 895537.
- Ghannoum MA., et al. “Characterization of the oral fungal microbiome (mycobiome) in healthy individuals”. PLOS Pathogen1 (2010): e1000713.
- Yoshihisa Yamashita and Toru Takeshita. “The oral microbiome and human health”. Journal of Oral Science 59 (2017): 201-206.
- Ghannoum MA., et al. “Characterization of the oral fungal microbiome (mycobiome) in healthy individuals”. PLOS Pathogen1 (2010): e1000713.
- Wade WG. “The oral microbiome in health and disease”. Pharmacology Research1 (2013): 137-143.
- Efenberger M., et al. “Archaea prevalence in inflamed pulp tissues”. D - 9702239. (- 1426-3912 (Print)): 194-200.
- Caselli E., et al. “Defining the oral microbiome by whole-genome sequencing and resistome analysis: the complexity of the healthy picture”. BMC Microbiology 20 (2020): 120.
- John J Rajasekaran., et al. “Oral Microbiome: A Review of Its Impact on Oral and Systemic Health”. Microorganisms 9 (2024): 1797.
- Bruno Pires Miranda., et al. “Beyond Bacteria: The Impact of Protozoa on Periodontal Health”. Microorganisms 13 (2025): 846.
- Schlagenhauf U. “On the Role of Dietary Nitrate in the Maintenance of Systemic and Oral Health”. Dentistry Journal 10 (2022): 84.
- Vanhatalo A., et al. “Nitrate-responsive oral microbiome modulates nitric oxide homeostasis and blood pressure in humans”. Free Radical Biology and Medicine 124 (2018): 21-30.
- Pytko-Polo nczyk J., et al. “Antioxidant-Rich Natural Raw Materials in the Prevention and Treatment of Selected Oral Cavity and Periodontal Diseases”. Antioxidants 10 (2021): 1848.
- Jia YJ., et al. “Association Between Oral Microbiota and Cigarette Smoking in the Chinese Population”. Frontiers in Cellular and Infection Microbiology 11 (2021): 658203.
- Wu J., et al. “Cigarette smoking and the oral microbiome in a large study of American adults”. ISME Journal 10 (2016): 2435-2446.
- Wagenknecht D., et al. “Effects of Nicotine on Oral Microorganisms, Human Tissues, and the Interactions between Them”. Current Oral Health Report 5 (2018): 78-87.
- https://www.who.int/news-room/fact-sheets/detail/alcohol
- Zhao Z., et al. “Alcohol exposure alters the diversity and composition of oral microbiome”. Frontiers in Cellular and Infection Microbiology 15 (2025): 1561055.
- Zhao Z., et al. “Alcohol exposure alters the diversity and composition of oral microbiome”. Frontiers in Cellular and Infection Microbiology 15 (2025): 1561055.
- Fan X., et al. “Drinking alcohol is associated with variation in the human oral microbiome in a large study of American adults”. Microbiome 6 (2018): 59.
- Roberts AP and Kreth J. “The impact of horizontal gene transfer on the adaptive ability of the human oral microbiome”. Frontiers in Cellular and Infection Microbiology 4 (2014): 124.
- Banas JA and Drake DR. “Are the mutans streptococci still considered relevant to understanding the microbial etiology of dental caries?” BMC Oral Health 18 (2018): 129.
- Baker JL., et al. “Deep metagenomics examines the oral microbiome during dental caries, revealing novel taxa and co-occurrences with host molecules”. Genome Research (2021): 3164-3174.
- Rosier BT., et al. “Nitrate as a potential prebiotic for the oral microbiome”. Scientific Report 10 (2020): 12895.
- Rosier BT., et al. “The importance of nitrate reduction for oral health. J. Dent. Res (2022).
- Darveau RP. “Periodontitis: a polymicrobial disruption of host homeostasis”. Nature Reviews Microbiology 8 (2010): 481-490.
- Moore WE and Moore LV. “The bacteria of periodontal diseases”. Periodontology 2000 5 (1994): 66-77.
- Cai Z., et al. “Structure and function of oral microbial community in periodontitis based on integrated data”. Frontiers in Cellular and Infection Microbiology 11 (2021): 663756.
- Martínez A., et al. “The human oral virome: shedding light on the dark matter”. Periodontology 2000 87 (2021): 282-298.
- Marshall Barry J., et al. “Prospective Double-Blind Trial of Duodenal Ulcer Relapse After Eradication of Campylobacter Pylori”. Lancet 332 (1988): 1437-1442.
- Moore PS and Chang YH. “Why do viruses cause cancer? Highlights of the first century of human tumour virology”. Nature Reviews Cancer 10 (2010): 878-89.
- Corbella S., et al. “Is periodontitis a risk indicator for cancer? A meta-analysis”. PLoS One 13 (2018): e0195683.
- Irfan M., et al. “The Oral Microbiome and Cancer”. Frontiers in Immunology 11 (2020): 591088.
- Whitmore SE and Lamont RJ. “Oral bacteria and cancer”. PLoS Pathogens3 (2014): e1003933.
- Rajasekaran JJ., et al. “Oral Microbiome: A Review of Its Impact on Oral and Systemic Health”. Microorganisms 12 (2024): 1797.
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