Ola M Ezzatt*

Professor of Oral Medicine, Periodontology, and Oral Diagnosis, Faculty of Dentistry, Ain Shams University and Manager of Central Lab of Stem Cells and Biomaterial Applied Research (CLSBAR), Faculty of Dentistry, Ain-Shams University, Cairo, Egypt

*Corresponding Author: Ola M Ezzatt, Professor of Oral Medicine, Periodontology, and Oral Diagnosis, Faculty of Dentistry, Ain Shams University and Manager of Central Lab of Stem Cells and Biomaterial Applied Research (CLSBAR), Faculty of Dentistry, Ain-Shams University, Cairo, Egypt.

Received: April 17, 2025; Published: April 24, 2025

Abstract

Background: Periodontitis can lead to progressive and irreversible damage of the periodontium, including gingival recessions, loss of soft tissue attachment, intra-bony defects, and eventually tooth loss. In recent years, stem cell-based therapy has been introduced for periodontal tissue regeneration, but the potential effect of this therapy is still unclear. This scoping review aims to systematically explore and outline the available literature that investigated the potential of stem cells in periodontal regeneration.

Methods: A comprehensive electronic review of the available literature in PubMed, Clinical Trial Registration Site, Web of Science, and Scopus databases was conducted in January 2024 within a time frame starting from January 2014. This scoping review follows the extension of PRISMA-sR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) as a guideline and includes all studies that investigated the use of any type of stem cells in periodontal tissue regeneration.

Results: The initial search in databases yielded (1213) articles. The (28) included articles that met the eligibility criteria were (4) registered clinical trials, (19) pre-clinical studies, and (5) published eligible randomized clinical trials (RCTs).

Conclusions: Stem cell-based therapy showed promising results in the field of periodontal regeneration, particularly periodontal ligament stem cells (PDLSCs), but the path from basic research to practical therapeutic use is still ongoing.

Keywords: Periodontal; Oral Diagnosis

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Citation

Citation: Ola M Ezzatt., et al. “Stem Cells in Periodontal Regeneration: A Scoping Review".Acta Scientific Dental Sciences 9.5 (2025): 28-41.

Copyright

Copyright: © 2025 Ola M Ezzatt., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.