Carlos Juan Puig Gonzalez, Otto Alemán Miranda*, Giselle Ramos Martínez, José Luis Martínez Montes de Oca, Catherine Barroso Rodriguez and Karen Barroso Rodríguez

Private Practice, USA

*Corresponding Author: Otto Alemán Miranda, Private Practice, USA.

Received: March 19, 2025; Published: April 07, 2025

Abstract

Introduction: Undifferentiated squamous cell carcinoma (USCC) is a rare and aggressive variant of squamous cell carcinoma, with a higher capacity for dissemination and recurrence. Its prevalence in the head and neck region is low, accounting for approximately 1% to 2% of all squamous cell carcinoma cases.

Case Report: A case of USCC in the genian region with extension to the parotid gland and cervical lymph nodes is presented. The patient underwent extensive surgical resection, including parotidectomy and lymph node dissection. Despite the treatment, tumor recurrence was observed during follow-up, highlighting the aggressiveness and high recurrence rate of this tumor type.

Discussion: USCC is characterized by a high rate of perineural invasion, lymph node dissemination, and local recurrence. The genian region, due to its constant sun exposure and proximity to critical structures like the parotid gland and lymph nodes, is considered high-risk. Treatment should be aggressive, involving wide surgical resection, lymph node dissection, and adjuvant radiotherapy, especially in cases of undifferentiated carcinoma.

Conclusions: Early diagnosis and appropriate treatment are crucial for improving the prognosis of USCC. Postoperative follow-up must be thorough due to the high recurrence rate. The genian region presents complex surgical and prognostic challenges, requiring a multidisciplinary approach.

Keywords: Benign Lesion; Malignant Tumor; Aggressive Carcinoma; Malignant Transformation

References

1. Weatherspoon DJ., et al. “Squamous cell carcinoma of the head and neck: a review of current treatment protocols”. Journal of Clinical Oncology5 (2024): 256-270.
2. Jones TM., et al. “Advances in the management of head and neck cancer: an overview of modern approaches to treatment”. Lancet Oncology11 (2023): 1281-1292.
3. Mlynarek AM., et al. “Current concepts in head and neck squamous cell carcinoma: advances in diagnosis and management”. Journal of Surgical Oncology7 (2023): 788-794.
4. Yin J., et al. “Clinical significance of biopsy techniques in head and neck cancers”. Head Neck10 (2023): 2345-2352.
5. Adams JA., et al. “Role of adjuvant therapy in head and neck squamous cell carcinoma”. Oral Oncology 124 (2022): 105591.
6. Manoharan S., et al. “Parotid gland involvement in head and neck cancer: treatment strategies and outcomes”. Journal of Clinical Oncology8 (2023): 907-915.
7. Wykoff A., et al. “Prognostic factors for survival and recurrence in head and neck squamous cell carcinoma”. Journal of Cancer Research and Clinical Oncology 4 (2023): 853-860.
8. Rees RC., et al. “The role of neck dissection in the management of head and neck cancers”. Head and Neck Surgery 2 (2023): 112-118.
9. Lee GY., et al. “Outcomes and prognostic factors in patients with parotid gland carcinoma: A retrospective cohort study”. Oral Diseases 6 (2022): 1519-1525.
10. Gupta S., et al. “Squamous cell carcinoma of the genian region: clinical behavior and treatment outcomes”. Oral Surgery, Oral Medicine, Oral Pathology, and Oral Radiology 2 (2022): 187-193.
11. Wu N., et al. “Radiotherapy for squamous cell carcinoma of the head and neck: advances and challenges”. Radiation Oncology 1 (2023): 1-9.
12. Singh R., et al. “Pathology of head and neck carcinoma: A comprehensive review”. Cancer Treatment and Research Communications 31 (2022): 100547.
13. Leung AKC., et al. “Diagnostic imaging of parotid tumors: how imaging helps guide clinical decisions”. Oral and Maxillofacial Surgery Clinics of North America 2 (2023): 217-228.
14. Chuang J., et al. “Genetic mutations in head and neck squamous cell carcinoma: implications for treatment”. Journal of Clinical Oncology 12 (2022): 1391-1402.
15. Jones MK., et al. “The importance of early diagnosis and management in head and neck cancer: a focus on biopsy techniques”. American Journal of Otolaryngology 1 (2022): 102751.

Citation

Citation: Otto Alemán Miranda., et al. “From Benign Lesion to Aggressive Carcinoma: Lessons from a Misdiagnosed Case".Acta Scientific Dental Sciences 9.5 (2025): 13-17.

Copyright

Copyright: © 2025 Otto Alemán Miranda., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.