Radiation-Induced Changes in the Temporomandibular Joint and Synovial Fluid Leading to Radiation-Induced Trismus
Efsun Somay1*, Erkan Topkan2, Sibel Bascil3 and Ugur Selek4
1Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Baskent University, Ankara, Turkey
2Department of Radiation Oncology, Faculty of Medicine, Baskent University, Adana, Turkey
3Department of Periodontology, Faculty of Dentistry, Baskent University, Ankara, Turkey
4Department of Radiation Oncology, School of Medicine, Koc University, Istanbul, Turkey
*Corresponding Author: Efsun Somay, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Baskent University, Ankara, Turkey.
Received:
May 29, 2024; Published: June 14, 2024
Abstract
Radiation therapy (RT) is an integral and indispensable treatment modality for most head and neck cancers (HNCs). Ionizing RT's impact on the temporomandibular joint (TMJ) and the synovial fluid is pivotal yet often overlooked. Although radiation therapy successfully combats cancer, it may also cause complex changes in the surrounding tissues, such as the TMJ and synovial fluid, which can lead to serious radiation-induced damage in these tissues. It is crucial to gain a comprehensive understanding of these changes to maximize the quality of patient care and achieve positive outcomes. Radiation-induced inflammation and fibrosis in the soft tissues can lead to stiffness, limited mobility, and persistent pain around the TMJ. Additionally, changes in the movement and flow of synovial fluid, including decreased production and damage to the synovial membrane, can accelerate the deterioration and development of osteoarthritic changes within the joint. The impact of ionizing radiation on the TMJ carries significant clinical implications, resulting in diminished oral functions, osteoradionecrosis, and degenerative TMJ disorders. Effective collaboration between related disciplines and proactive management strategies is vital for mitigating adverse repercussions and optimizing patient outcomes. By elucidating these consequences, healthcare professionals can customize treatment modalities, advance patient care, and ultimately enhance results for individuals undergoing RT for HNCs. Accordingly, this review has been meticulously prepared to amalgamate current knowledge about the multifaceted effects of RT on the TMJ and its associated synovial fluid.
Keywords: Radiotherapy; Head and Neck Cancer; Temporomandibular Joint; Synovial Fluid
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