Nidhi Yadav*, Manini Singh, Amit Wadhawan and Prashant Tyagi

Department of Periodontology, Shree Bankey Bihari Dental College and Research Centre, Masuri Ghaziabad, India

*Corresponding Author: Nidhi Yadav, Department of Periodontology, Shree Bankey Bihari Dental College and Research Centre, Masuri Ghaziabad, India.

Received: May 09, 2024; Published: May 31, 2024

Abstract

In order to complement non-surgical therapy in periodontitis, there are multiple options of antimicrobials, such as metronidazole, chlorhexidine, minocycline, doxycycline, and tetracycline etc which can be locally delivered into the mucosa. These medications are applied within periodontal pockets to hinder or eradicate periodontal disease-causing microorganisms, while also regulating the inflammatory reaction of tissues. This review seeks to assess the impact and effectiveness of various forms of localized drug delivery systems on clinical parameters within periodontology. The supplemental utilization of localized drug delivery systems featuring controlled release characteristics may offer a specific yet constrained advantageous effect on periodontal pockets. Moreover, employing local drug delivery for either active treatment or maintenance therapy hinges on clinical observations, treatment responses detailed in literature, intended clinical results, and the dental and medical backgrounds of patients, encompassing their prior antimicrobial usage.

Keywords: Periodontitis; Doxycycline; Tetracycline; Metronidazole; Minocycline; Chlorhexidine; Local Drug Delivery

References

1. Rajpoot AS., et al. “Local drug delivery in periodontics”. International Journal of Research in Health and Allied Sciences 3 (2017): 63-67.
2. Júnior HAR., et al. “Local Drug Delivery Systems in the Treatment of Periodontitis: A Literature Review”. Journal of the International Academy of Periodontology3 (2015): 82-90.
3. Rams TE and Slots J. “Local delivery of antimicrobial agents in the periodontal pocket”. Journal of Periodontology 20001 (1996): 139-159.
4. Goodson JM., et al. “Periodontal disease treatment by local drug delivery”. Journal of Periodontology 20005 (1985): 265-272.
5. Gupta R., et al. “Local Drug Delivery - A New Concept in Dentistry”. Journal of Clinical Dental Research and Education 5 (2014): 265-272.
6. Goodson JM., et al. “Monolithic tetracycline-containing fibers for controlled delivery to periodontal pockets”. Journal of Periodontology 10 (1983): 575-579.
7. Khan FY., et al. “Clinical utility of locally-delivered collagen-based biodegradable tetracycline fibers in periodontal therapy: an in vivo study”. Journal of Investigative and Clinical Dentistry 4 (2015): 307-312.
8. Maheshwari M., et al. “Development of tetracycline-serratiopeptidase containing periodontal gel: formulation and pre-liminary clinical study”. AAPS Pharm Sci Tech3 (2006): 162-171.
9. Polson AM., et al. “Multicenter comparative evaluation of subgingivally delivered sanguinarine and doxycycline in the treatment of Periodontitis. Clinical results”. Journal of Periodontology 68 (1997): 119-126.
10. Bernardi S., et al. “Microbiological and SEM-EDS evaluation of titanium surfaces exposed to periodontal gel: In vitro study”. Materials9 (2019): 1448.
11. Gürkan A., et al. “Post-treatment effects of sub-antimicrobial dose doxycycline on clinical parameters and gingival crevicular fluid transforming growth factor-beta1 in severe, generalized chronic periodontitis”. International Journal of Dental Hygiene 2 (2008): 84-92.
12. Pragati S., et al. “Recent advances in periodontal drug delivery systems”. International Journal of Drug Delivery 1 (2009): 1-14.
13. Higashi K. “Local ofloxacin delivery using a controlled-release insert (PT-01) in the human periodontal pocket”. Journal of Periodontal Research 1 (1990): 1-5.
14. Júnior HAR., et al. “Local Drug Delivery Systems in the Treatment of Periodontitis: A Literature Review”. Journal of International Academy of Periodontology 3 (2015): 82-90.
15. Archana B., et al. “To assess the effectiveness of a single subgingival application of chlorhexidine chip in the treatment of chronic periodontitis: a clinical study”. Journal of Pharmaceutical and Biomedical Sciences 20 (2012): 1-7.
16. Grover V., et al. “To assess the effectiveness of a chlorhexidine chip in the treatment of chronic periodontitis: a clinical and radiographic study”. Journal of Indian Society of Periodontology 15 (2011): 139-146.
17. Dodwad V., et al. “Local drug delivery in periodontics: a strategic intervention”. International Journal of Pharmacy and Pharmaceutical Sciences 4 (2012): 30-34.
18. Menezes AM., et al. “Effect of sodium alendronate on alveolar bone resorption in experimental periodontitis in rats”. Journal of Periodontology 76 (2005): 1901-1909.
19. Gupta SC. “Local Drug delivery in periodontics”. Indian Journal of Dental Research 1 (2010): 32-34.
20. Cooke JW., et al. “Effect of rhPDGF-BB delivery on mediators of periodontal wound repair”. Tissue Engineering 6 (2006): 1441-1450.
21. Kishen A., et al. “An investigation on the antibacterial properties and antibiofilm efficacy of cationic nanoparticulates for root canal disinfection”. Journal of Endodontics 34 (2008): 1515-1520.
22. Avani R Pradeep and Manojkumar S Thorat. “Clinical Effect of Sub-gingivally Delivered Simvastatin in the Treatment of Patients with Chronic Periodontitis: A Randomized Clinical Trial”. Journal of Periodontology 81 (2010): 214-222.
23. Pradeep AR and Thorat MS. “Clinical effect of sub-gingivally delivered simvastatin in the treatment of patients with chronic periodontitis: a randomized clinical trial”. Journal of Periodontology 2 (2010): 214-22.
24. Veena HR and Prasad D. “Evaluation of an amino-bisphosphonate (alendronate) in the management of periodontal osseous defects”. Journal of Periodontology 1 (2010): 40-45.
25. Binderman I., et al. “Effectiveness of local delivery of Alendronate in reducing alveolar bone loss following periodontal surgery in rats”. Journal of Periodontology 71 (2000): 1236-1240.
26. Pradeep AR., et al. “1% alendronate gel as local drug delivery in the treatment of Class II furcation defects: a randomized controlled clinical trial”. Journal of Periodontology 3 (2013): 307-315.
27. Zieba M., et al. “Polymeric carriers for delivery systems in the treatment of chronic periodontal disease”. Polymers 12 (2020): 1574.
28. Ozdogan AI., et al. “Development and in vitro evaluation of chitosan based system for local delivery of atorvastatin for treatment of periodontitis”. European Journal of Pharmaceutical Sciences 124 (2018): 208-216.
29. Bansal M., et al. “Clinical evaluation of thermoresponsive and mucoadhesivechitosan in situ gel containing levofloxacin and metronidazole in the treatment of periodontal pockets-a split-mouth, clinical study”. Journal of Pierre Fauchard Academy 30 (2016): 6-14.
30. Mihalache C., et al. “Bupivacaine-loaded chitosan hydrogels for topical anesthesia in dentistry”. Polymer International 69 (2020): 1152-1160.
31. Chang HI., et al. “Controlled release of an antibiotic, gentamicin sulphate, from gravity spun polycaprolactone fibers”. Journal of Biomedical Materials Research 84 (2008): 230-237.

Citation

Citation: Nidhi Yadav., et al. “Local Drug Delivery Systems: A Literature Review".Acta Scientific Dental Sciences 8.6 (2024): 68-74.

Copyright

Copyright: Nidhi Yadav., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.