Zilberman U¹*, Malul M1 and Abramovitz H²

¹Pediatric Dental Unit, Barzilai Medical University Center, Ashkelon, affiliated to Ben Gurion University of the Negev, Beer Sheva, Israel
²Department of Physiology and Cell Biology, Faculty of Cell Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel

*Corresponding Author: Zilberman U, Pediatric Dental Unit, Barzilai Medical University Center, Ashkelon, affiliated to Ben Gurion University of the Negev, Beer Sheva, Israel.

Received: May 02, 2024; Published: May 16, 2024

Abstract

MIH (Molar Incisor Hypomineralization), a qualitative reduction of enamel mineralization, became a world wide burden in pediatric dentistry. The prevalence of the phenomenom increased during the last decades from 3% to 13.5% worldwide. In israel the prevalence is almost 18% and an increase of 2% was observed between the young and older group. In hypomineralized molars a significant reduction in mineral content was observed. The aim of the present study was to analyze the proteomics of permanent and deciduous molars affected by hypomineralization. A sample of 5 permanent molars affected by MIH was compared to 5 healthy teeth ans another sample of 5 deciduous molars affected by dmh was compared to 5 healthy teeth. The results showed that almost 370 proteins were detected and 37 of them showed a significant statistical difference between the affected and the healthy groups. PCA analysis showed distinct grouping between affected molars and healthy teeth in both permanent and deciduous molars. This study shows that there is a significant difference between the proteins content in MIH and DMH enamel in comparison with healthy enamel

Keywords: MIH; DMH; Enamel; Proteomics

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Citation

Citation: Zilberman U., et al. “Proteomics of MIH and DMH Affected Permanent and Primary Molars".Acta Scientific Dental Sciences 8.6 (2024): 10-16.

Copyright

Copyright: © 2024 Zilberman U., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.