Dileep Kishore¹*, Vartika Verma², Shipra Singhal³, Prakirti Chaudhary⁴ and Kay Kay Puying¹

¹PG Student, Department of Periodontology and Oral Implantology, Teerthanker Mahaveer Dental College and Research Centre, Moradabad, India
²Assistant Professor, Department of Periodontology and Oral Implantology Kalka Dental College, Meerut, India
³PG Student, Department of Conservative Dentistry and Endodontics, Teerthanker Mahaveer Dental College and Research Centre, Moradabad, India
⁴Department of Periodontology and Oral Implantology, Teerthanker Mahaveer Dental College and Research Centre, Moradabad, India

*Corresponding Author: Dileep Kishore, Department of Periodontology, Teerthanker Mahaveer University, Moradabad (U.P), India.

Received: January 05, 2024; Published: January 29, 2024

Abstract

The term periodontal diseases describes inflammation of the tissues that offer support to the teeth. It has been recognized that though the bacteria present in plaque initiates the periodontal inflammation, the host response to these pathogens equally matters in the progression of the disease. The immune cells participate jointly through the release of their molecules and mechanisms of action in order to maintain homeostasis in periodontal tissues, so the host’s immune response plays an essential role in defense against microorganisms. Therefore, the severity of this disease is due to a variety of factors, including the presence of periodontopathic bacteria, high levels of proinflammatory mediators and low levels of anti-inflammatory mediators. This review attempts to enlighten the role of immune mechanisms involved in periodontal initiation and progression.

Keywords:Immunity; Health; Disease

References

1. Becerra-Ruiz JS., et al. “Innate and adaptive immunity of periodontal disease. From etiology to alveolar bone loss”. Oral Diseases (2021): 1-7.
2. Tatakis DN and Kumar PS. “Etiology and pathogenesis of periodontal diseases”. Dental Clinics3 (2005): 491-516.
3. Page RC and Schroeder HE. “Pathogenesis of inflammatory periodontal diseases. A summary of current work”. Laboratory Investigation 3 (1976): 235-249.
4. Nisengard RJ. “The role of immunology in periodontal disease”. Journal of Periodontology 9 (1977): 505-516.
5. Seymour GJ., et al. “Conversion of a stable T-cell lesion to a progressive B-cell lesion in the pathogenesis of chronic inflammatory periodontal disease: an hypothesis”. Journal of Clinical Periodontology 5 (1979): 267-277.
6. Page RC and Schroeder HE. “Current status of the host response in chronic marginal periodontitis”. Journal of Periodontology 9 (1981): 477-491.
7. Van Dyke TE. “Role of the neutrophile in oral disease: Receptor deficiency in leuckocytes from patients with juvenile periodontitis”. Reviews of Infectious Diseases 3 (1985): 419-425.
8. Ranney RR. “Immunologic mechanisms of pathogensis in periodontal diseases: An assessment”. Journal of Periodontal Research3 Pt2 (1991): 243-254.
9. Seymour GJ. “Possible mechanism involved in the immunoregulation of chronic inflammatory periodontal disease”. Journal of Dental Research1 (1987): 2-9.
10. Loe H., et al. “Natural history of periodontal disease in man. Rapid, moderate and no loss of attachment in Sri lankan laborers 14 to 46 years of age”. Journal of Periodontology 5 (1986): 431-445.
11. Preber H and Bergstorm J. “Occurrence of gingival bleeding in smoker and non-smoker patients”. Acta Odontologica Scandinavica 5 (1985): 315-320.
12. Preber H and Bergstorm J. “Cigarette smoking in patients referred for periodontal treatment”. Scandinavian Journal of Dental Research 2 (1986): 102-108.
13. Bergstrom J. “Periodontitis and smoking: An evidence based appraisal”. Journal of Evidence-Based Dental Practice 1 (2006): 16-23.
14. Haber J., et al. “Evidence for cigarette smoking as a major risk factor for periodontitis”. Journal of Periodontology 1 (1993): 16-23.
15. Kornman KS. “Mapping the pathogenesis of Periodontitis: A New Look”. Journal of Periodontology 8 (2008): 1560-1568.
16. Shimono M., et al. “Biological characteristics of the jinvtional epithelium”. Journal of Electron Microscopy (Tokyo) 6 (2003): 627-639.
17. Heymann R., et al. “The characterstics cellular organization and CEACAM1 expression in junctional epithelium of rats and mice are genetically programmed and not influenced by the bacterial microflora”. Journal of Periodontology 4 (2001): 454-460.
18. Larjava H., et al. “Epithelial integrins with special reference to oral epithelia”. Journal of Dental Research 12 (2011): 1367-1376.
19. Dunsche A., et al. “The novel human beta-defensin-3 is widely expressed in oral tissues”. European Journal of Oral Sciences 2 (2002): 121-124.
20. Lehrer RI and Ganz T. “Cathelicidins: a family of endogenous antimicrobial peptides”. Current Opinion in Hematology 1 (2002): 18-22.
21. Van Wetering S., et al. “Effect of neutrophil serine proteinases and defensins on lung epithelial cells: modulation of cytotoxicity and IL-8 production”. Journal of Leukocyte Biology 2 (1997): 217-226.
22. Kornman KS., et al. “The host response to the microbial challenge in periodontitis: assembling the players”. Periodontology 2000 14 (1997): 33-53.
23. Bickel M. “The role of interleukin-8 in inflammation and mechanisms of regulation”. Journal of Periodontology 5 (1993): 456-460.
24. Schroeder HE and Lindhe J. “Conversion of stable established gingivitis in the dog into destructive periodontitis”. Archives of Oral Biology 12 (1975): 775-782.
25. Akira S and Takeda K. “Toll-like receptor signalling”. Nature Reviews Immunology 4 (2004): 499-511.
26. Akira S., et al. “Pathogen recognition and innate immunity”. Cell 4 (2006): 783-801.
27. Cai X., et al. “The cGAS-cGAMP-STING pathway of cytosolic DNA sensing and signaling”. Molecular Cell 2 (2014): 289-296.
28. Hayashi S., et al. “Distinct osteoclast precursors in the bone marrow and extramedullary organs characterized by responsiveness to Toll-like receptor ligands and TNF-alpha”. The Journal of Immunology 10 (2003): 5130-5139.
29. Iwasaki A and Medzhitov R. “Toll-like receptor control of the adaptive immune responses”. Nature Immunology 5 (2004): 987-995.
30. Kaisho T and Akira S. “Toll-like receptors as adjuvant receptors”. Biochimica et Biophysica Acta 1 (2002): 1-13.
31. Takeda K., et al. “Toll-like receptors”. Annual Review of Immunology 21 (2003): 335-376.
32. Mosmann TR and Coffman RL. “TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties”. Annual Review of Immunology 7 (1989): 145-173.
33. Paul WE and Seder RA. “Lymphocyte responses and cytokines”. Cell 2 (1994): 241-251.
34. Fiorentino DF., et al. “Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones”. Journal of Experimental Medicine 6 (1989): 2081-2095.
35. Weaver CT., et al. “Th17: an effector CD4 T cell lineage with regulatory T cell ties”. Immunity6 (2006): 677-688.
36. Sato K., et al. “Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction”. Journal of Experimental Medicine 12 (2006): 2673-2682.
37. Nakajima T., et al. “Regulatory T-cells infiltrate periodontal disease tissues”. Journal of Dental Research 7 (2005): 639-643.

Citation

Citation: Dileep Kishore., et al. ““Immunity and its Role in Health and Disease: A Literature".Acta Scientific Dental Sciences 8.2 (2024): 77-82.

Copyright

Copyright: © 2024 Dileep Kishore., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.