Acta Scientific Dental Sciences (ASDS)(ISSN: 2581-4893)

Review Article Volume 7 Issue 10

Current Status and Future Prospects of Stem Cells in Dentistry-A Review

Anindita Kundoo and Vidya Dodwad*

Department of Periodontology, Bharati Vidyapeeth (Deemed to be) University, Dental College and Hospital, Pune, India

*Corresponding Author: Vidya Dodwad; Department of Periodontology, Bharati Vidyapeeth (Deemed to be) University, Dental College and Hospital, Pune, India.

Received: September 04, 2023; Published: September 26, 2023

Abstract

Stem cells are able to multiply and create cell lines that can develop into different cell lineages. Depending on their source, stem cells can either be adult or embryonic stem cells and can be taken from a variety of locations. Due to their capacity for self-renewal, they are employed to treat significant flaws brought about by diseases, injuries, or surgical procedures. They are nevertheless constrained by moral and ethical issues as well as the challenges of isolation, culturing, and implantation. The regeneration of orofacial structures uses dental stem cells, which still have the ability to differentiate into neurogenic, adipogenic, and odontogenic components. Prior to stem cell implantation, scaffolding that has been treated with bone morphogenic proteins and growth factors is crucial. The introduction of 3D scaffolding with biomatrix into the therapeutic setting will aid in the regeneration of tissues. The pulp, apical papilla, dental follicle, periodontal ligament, deciduous teeth, and mucosa in the maxillofacial region are possible sources of stem cells. They can be applied to the bioengineering of periodontal tissues, soft tissues, bone, and the temporomandibular joint. To fully use the enormous potential of stem cell therapy and ensure future treatment outcomes, a multispecialty strategy integrating cell biologists, pharmacologists, and bioengineers is necessary. As a result, this review provides a narrative of the development of stem cell use over time and clarifies the bioethical stance of today's various religions in relation to social ones with regard to the study and application of embryonic and adult stem cells.

Keywords: Periodontal Regeneration; Stem Cell; Stem Cell Therapy

References

  1. Granot N and Storb R. “History of hematopoietic cell transplantation: challenges and progress”. Haematologica 12 (2020): 2716-2729.
  2. Ballini A., et al. “Stemness genes expression in naive vs. osteodifferentiated human dental-derived stem cells”. European Review for Medical and Pharmacological Sciences7 (2019): 2916-2923.
  3. Girlovanu M., et al. “Stem cells - biological update and cell therapy progress”. Medicine and Pharmacy Reports3 (2015): 265-271.
  4. The Nobel Prizes. Gene modification in mice (2007).
  5. Thomson JA., et al. “Embryonic stem cell lines derived from human blastocysts”. Science 5391 (1998): 1145-1147.
  6. Ballen KK., et al. “Effect of cord blood processing on transplantation outcomes after single myeloablative umbilical cord blood transplantation”. Biology of Blood and Marrow Transplantation4 (2015): 688-695.
  7. Kusena JWT., et al. “Understanding cell culture dynamics: a tool for defining protocol parameters for improved processes and efficient manufacturing using human embryonic stem cells”. Bioengineered 1 (2021): 979-996.
  8. Ballini A., et al. “A comparative study on different stemness gene expression between dental pulp stem cells vs. dental bud stem cells”. European Review for Medical and Pharmacological Sciences4 (2019): 1626-1633.
  9. Ghamari SH., et al. “The bottlenecks in translating placenta derived amniotic epithelial and mesenchymal stromal cells into the clinic: current discrepancies in marker reports”. Frontiers in Bioengineering and Biotechnology 8 (2020): 180.
  10. Abdulrazzak H., et al. “Biological characteristics of stem cells from foetal, cord blood and extraembryonic tissues”. Journal of the Royal Society Interface6 (2010): S689-S706.
  11. Liu G., et al. “Advances in pluripotent stem cells: history, mechanisms, technologies, and applications”. Stem Cell Reviews and Reports1 (2020): 3-32.
  12. Majid S., et al. “Stem cells in dentistry: A boon to oral and maxillofacial surgery”. IOSR-JDMS1 (2016): 62-68.
  13. Mitsiadis TA., et al. “Stem cell-based approaches in dentistry”. European Cells and Materials 30 (2015): 248- 257.
  14. Rai S., et al. “Applications of stem cells in interdisciplinary dentistry and beyond: An overview”. Annals of Medical and Health Sciences Research2 (2013): 245-524.
  15. Ilic D and Ogilvie C. “Concise review: human embryonic stem cells-what have we done? What are we doing? Where are we going?” Stem Cells 35 (2017): 17-25.
  16. Rocha V., et al. “Clinical use of umbilical cord blood hematopoietic stem cells”. Biology of Blood and Marrow Transplantation 1 (2006): 34-44.
  17. Widuchowski W., et al. “Articular cartilage defects: study of 25,124 knee arthroscopies”. Knee 14 (2007): 177-182.
  18. Kroon E., et al. “Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo”. Nature Biotechnology 26 (2008): 443-452.
  19. Hayashi K., et al. “Reconstitution of the mouse germ cell specification pathway in culture by pluripotent stem cells”. Cell4 (2011): 519-532.
  20. Cordeiro MM., et al. “Dental pulp tissue engineering with stem cells from exfoliated deciduous teeth”. Journal of Endodontics 34 (2008): 962-969.
  21. Cai J., et al. “Generation of tooth-like structures from integration-free human urine induced pluripotent stem cells”. Cell Regen (London)1 (2013): 6.
  22. TR Nayak., et al. “Graphene for controlled and accelerated osteogenic differentiation of human mesenchymal stem cell”. ACS Nano (2011): 4670-4678.
  23. Gronthos S., et al. “Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo”. Proceedings of the National Academy of Sciences of the United States of America 25 (2000): 13625-13630.
  24. Zhu B., et al. “Somatic stem cell biology and periodontal regeneration”. The International Journal of Oral and Maxillofacial Implants 28 (2013): e494-e502.
  25. Han J., et al. “Stem cells, tissue engineering and periodontal regeneration”. Australian Dental Journal 59 (2014): 117-130.
  26. Tobita M., et al. “Periodontal tissue regeneration with adipose-derived stem cells”. Tissue Engineering Part A 6 (2008): 945-953.
  27. Takahashi K., et al. “Induction of pluripotent stem cells from adult human fibroblasts by defined factors”. Cell5 (2007): 861-872.
  28. Ledesma-Martínez E., et al. “Mesenchymal stem cells for periodontal tissue regeneration in elderly patients”. The Journals of Gerontology Series A Biological Sciences and Medical Sciences 74 (2019): 1351-1358.
  29. Cho YD., et al. “Recent advances of useful cell sources in the periodontal regeneration”. Current Stem Cell Research and Therapy 14 (2019): 3-8.
  30. Zhou LN., et al. “Macrophage polarization in human gingival tissue in response to periodontal disease”. Oral Diseases 25 (2019): 265-273.

Citation

Citation: Anindita Kundoo and Vidya Dodwad. “Current Status and Future Prospects of Stem Cells in Dentistry-A Review"Acta Scientific Dental Sciences 7.10 (2023): 105-112.

Copyright

Copyright: © 2023 Anindita Kundoo and Vidya Dodwad. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




Metrics

Acceptance rate30%
Acceptance to publication20-30 days
Impact Factor1.278

Indexed In





News and Events


  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is July 10, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

Contact US