Acta Scientific Dental Sciences (ASDS)(ISSN: 2581-4893)

Research Article Volume 7 Issue 8

Evaluation of Pain-Relieving Effect of Menthol, Diclofenac and Benzocaine Patches in Orthodontic Patients - In Vivo Study

Shahina Salim1, Alok K Anil1, Amrutha Hari1, Aishwarrya P2*, Mansi Singh3 and Arsha Darsh1*

1Orthodontics and Dentofacial Orthopedics PG Resident, PMS College of Dental Science and Research Trivandrum, Kerala, India
2Consultant Orthodontist, Uttar Pradesh, India
3Assistant Professor, Department of Orthodontics, Kalka Dental College, India

*Corresponding Author: Aishwarrya P, Consultant Orthodontist, Uttar Pradesh, India.

Received: June 16, 2023; Published: July 05, 2023


Background: The Purpose of this study was to evaluate the efficacy of benzocaine, menthol and diclofenac mucoadhesive patches in pain control caused by separation of teeth during orthodontic treatment by means of visual analog scale and numeric rating scale.

Materials and methods: Split mouth technique with 60 samples from Department of Orthodontics and Dentofacial Orthopaedics, PMS college of dental science and research, Trivandrum for orthodontic treatment were included in the study. The patient with consent was considered for the study. Elastomeric separators were placed mesial and distal to first maxillary molars in one quadrants and the placebo patches were placed on the other quadrant. The medication patch and the placebo patch were distributed among the three groups of 20 patients each. For both of their first maxillary molars, the patients were given Visual Analogue Scales (VAS) and Numerical Rating Scales (NRS). The Mann-Whitney U test and Krausal test analyses were done after data collection. The patient recorded readings every six hours beginning 30 minutes after the patch insertion. The mucoadhesive drug and placebo patch was replaced after 48 hours and every six hours, the reading was remarked, and the final marking was conducted at 72nd hour and mucoadhesive patch was replaced.

Results: There was statistically significant reduction in pain due when mucoadhesive drug patch was compared with the placebo patch.It was seen that benzocaine was most effective at 6th, 48th,72nd hour, followed by diclofenac which was effective at 6th, 48th, 72nd hour and menthol effective at 6th, 12th, 18th, 48th 72nd hour. On overall comparison of three patches it was observed that benzocaine was significantly effective in relieving pain caused due to separators.

Conclusion: It can be concluded from the study that drug patches were effective in reducing pain caused by elastomeric separators as compared to the placebo patch. The use of benzocaine patches was most effective followed by diclofenca mucoadhesive patch and menthol.

Keywords: Menthol; Diclofenac; Benzocaine; Patients


  1. Firestone AR., et al. “Patients' anticipation of pain and pain-related side effects, and their perception of pain as a result of orthodontic treatment with fixed appliances”. European Journal of Orthodontics 21 (1999): 387-396. 
  2. Vachiramon A and Wang WC. “Acupuncture and acupressure techniques for reducing orthodontic post-adjustment pain”. The Journal of Contemporary Dental Practice 1 (2005): 163-167.
  3. Oliver RG and Knapman YM. “Attitudes to orthodontic treatment”. British Journal of Orthodontics 4 (1985): 179-188. 
  4. Vachiramon A and Wang WC. “Acupuncture and acupressure techniques for reducing orthodontic post-adjustment pain”. The Journal of Contemporary Dental Practice 1 (2005): 163e7.
  5. Ngan P., et al. “Perception of discomfort by patients undergoing orthodontic treatment”. American Journal of Orthodontics and Dentofacial Orthopedics 96 (1989): 47-53.
  6. Eslamian L., et al. “The effect of benzocaine and ketoprofen gels on pain during fixed orthodontic appliance treatment: a randomised, double-blind, crossover trial”. Australasian Orthodontic Journal 1 (2016): 64e72.
  7. Lasanen R., et al. “Menthol € concentration in topical cold gel does not have significant effect on skin cooling”. Skin Research and Technology 1 (2016): 40e5.
  8. Chandrashekar A., et al. “Comparative evaluation of diclofenac and meloxicam as tablets and as transmucosal mucoadhesive patches in dental pain reduction”. International Journal of Pharmaceutical Science and Research 5 (2020): 2217-2222.
  9. Ladan Eslamian., et al. “The analgesic effect of benzocaine mucoadhesive patches on orthodontic pain caused by elastomeric separators, a preliminary study”. Acta Odontologica Scandinavica (2013).
  10. Annigeri RG., et al. “Clinical evaluation of transmucosal mucoadhesive meloxicam patch in dental pain reduction: A preliminary study”. Indian Journal of Pain2 (2015): 82.


Citation: Aishwarrya P., et al. “Evaluation of Pain-Relieving Effect of Menthol, Diclofenac and Benzocaine Patches in Orthodontic Patients - In Vivo Study".Acta Scientific Dental Sciences 7.8 (2023): 08-11.


Copyright: © 2023 Sana’a Abdulrazzaq Ibrahim Alrubaie., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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