Octenidine Dihydrochloride: A New Age Antimicrobial Agent
Seema Dental College and Hospital, Rishikesh Uttarakhand, India
*Corresponding Author: Seema Dental College and Hospital, Rishikesh Uttarakhand, India.
Received: June 16, 2023; Published: June 28, 2023
Chlorhexidine, that is an example of second generation chemical plaque control agent, possess cationic properties. For the past 40 years, it has been rigorously investigated and found that it possess superior antiplaque activity as compared to any other antimicrobial agents and hence, it is considered as a gold standard for plaque control. However, its long term use is prohibited because of certain side effects. The most common side effect associated with its long term use is the extrinsic staining. Some evidence in the literature also suggests that its frequent use lead to the alterations in the taste sensations, desquamation of the oral mucosa etc. These drawbacks led to the development and usage of other plaque control agents such as Octenidine dihydrochloride. Octenidine dihydrochloride, is an antimicrobial cationic surfactant and it belongs to the second generation of chemical plaque control agents. It was developed at the Sterling-Winthrop Research Institute, Rensselaer, NY in the 1980s. A concentration of 0.1% in mouthwashes along with different additives, flavouring agents and excipients is approved for the treatment of gingivitis, halitosis, as pre and post-surgical periodontal and oral procedures.
Keywords:Octenidine Dihydrochloride; Chlorhexidine; Mouthwashes; Second Generation Chemical Plaque Control; Periodontal Disease
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