Acta Scientific Dental Sciences (ASDS)(ISSN: 2581-4893)

Review Article Volume 7 Issue 7

Octenidine Dihydrochloride: A New Age Antimicrobial Agent

Anamika*

Seema Dental College and Hospital, Rishikesh Uttarakhand, India

*Corresponding Author: Seema Dental College and Hospital, Rishikesh Uttarakhand, India.

Received: June 16, 2023; Published: June 28, 2023

Abstract

Chlorhexidine, that is an example of second generation chemical plaque control agent, possess cationic properties. For the past 40 years, it has been rigorously investigated and found that it possess superior antiplaque activity as compared to any other antimicrobial agents and hence, it is considered as a gold standard for plaque control. However, its long term use is prohibited because of certain side effects. The most common side effect associated with its long term use is the extrinsic staining. Some evidence in the literature also suggests that its frequent use lead to the alterations in the taste sensations, desquamation of the oral mucosa etc. These drawbacks led to the development and usage of other plaque control agents such as Octenidine dihydrochloride. Octenidine dihydrochloride, is an antimicrobial cationic surfactant and it belongs to the second generation of chemical plaque control agents. It was developed at the Sterling-Winthrop Research Institute, Rensselaer, NY in the 1980s. A concentration of 0.1% in mouthwashes along with different additives, flavouring agents and excipients is approved for the treatment of gingivitis, halitosis, as pre and post-surgical periodontal and oral procedures.

Keywords:Octenidine Dihydrochloride; Chlorhexidine; Mouthwashes; Second Generation Chemical Plaque Control; Periodontal Disease

References

  1. Hubner NO., et al. “Octenidine dihydrochloride, a modern antiseptic for skin, mucous membranes and wounds”. Skin Pharmacology and Physiology5 (2010): 244-258.
  2. Renuka S and Muralidharan N P. “Comparison in benefits of Herbal Mouthwashes with Chlorhexidine Mouthwash: A review”. Asian Journal of Pharmaceutical and Clinical Research2 (2017): 3-7.
  3. Sajjan P., et al. “Chlorhexidine as an Antimicrobial Agent in Dentistry - A Review”. Oral Health and Dental Management2 (2016): 93-100.
  4. Bagchi S., et al. “Evaluation of efficacy of a commercially available herbal mouthwash on dental plaque and gingivitis: A double‑blinded parallel randomized controlled trial”. Journal of Indian Association of Public Health Dentistry 13 (2015): 222-227.
  5. Garner NO., et al. “Octenidine dihydrochloride, a new age antiseptic for skin, mucous membranes and wounds”. Skin Pharmacology and Physiology5 (2014): 344-358.
  6. Krishnan U., et al. “Free Active chlorine in sodium hypochlorite solutions admixed with octenidine, SmearOFF, chlorhexidine, and EDTA”. Journal of Endodontics8 (2017): 1354-1359.
  7. Van Meurs SJ., et al. “Selection of an optimal antiseptic solution for intraoperative irrigation: an in vitro study”. The Journal of Bone Joint Surgery American Volume4 (2014): 285-291.
  8. Melhorn S and Staubach P. “Octenidine dihydrochloride: the antiseptic that does not like every base formulation”. Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete (2018).
  9. Müller G and Kramer A. “Biocompatibility Index of Antiseptic Agents by Parallel Assessment of Antimicrobial Activity and Cellular Cytotoxicity”. Journal of Antimicrobial Chemotherapy 16 (2008): 1281-1287.
  10. Maillard J Y., et al. “Antimicrobial Stewardship of Antiseptics That Are Pertinent to Wounds: The Need for a United Approach”. JAC Antimicrobial Resistance 3 (2021).
  11. National Center for Biotechnology Information. “Octenidine hydrochloride”. PubChem Compound Database; CID = 51166 (2018).
  12. Kramer A., et al. “Octenidine, chlorhexidine, iodine and iodophores, with introductory chapter antisepsis; in Kramer A, Assadian O (eds): Wallhäussers Praxis der Sterilisation, Desinfektion, Antiseptik und Konservierung, ed 1, reprint. Stuttgart, Thieme (2008).
  13. Slee AM and OConnor JR. “In vitro antiplaque activity of octenidine dihydrochloride against preformed plaques of selected oral plaque-forming microorganisms”. Antimicrobial Agents and Chemotherapy 23 (1983): 379-384.
  14. Amalaradjou MA and Venkitanarayanan K. “Antibiofilm effect of octenidine hydrochloride on staphylococcus aureus, MRSA and VRSA”. Pathogens2 (2014): 404-416.
  15. Pitten FA., et al. “A standardized test to assess the impact of different organic challenges on the antimicrobial activity of antiseptics”. Journal of Hospital Infection 55 (2003): 108-115.
  16. Shapiro S., et al. “An in vitro oral biofilm model for comparing the efficacy of antimicrobial mouthrinses”. Caries Research 36 (2002): 93-100.
  17. Bartoszewicz M., et al. “Penetration of a selected antibiotic and antiseptic into a biofilm formed on orthopedic steel implants”. Journal of Orthopedics Traumatology and Rehabilitation 9 (2007): 310-318.
  18. Bock L J., et al. “Growth media and assay plate material can impact on the effectiveness of cationic biocides and antibiotics against different bacterial species”. Letters in Applied Microbiology5 (2018): 368-377.
  19. Kapalschinski N., et al. “Albumin reduces the antibacterial efficacy of wound antiseptics against Staphylococcus aureus”. Journal of Wound Care4 (2017): 184-187.
  20. Ghannoum MA., et al. “Antimycotic effects of octenidine and pirtenidine”. Journal of Antimicrobial Chemotherapy 25 (1990): 237-245.
  21. Hübner N., et al. “Direct comparison of microbiostatic and microbicidal efficacy of triclosan, PVP iodine, octenidine dihydrochloride, polihexanide and chlorhexidine digluconate”. Journal of Antimicrobial Chemotherapy3 (2019): 32-45.
  22. Rohrer N., et al. “Antimicrobial efficacy of 3 oral antiseptics containing octenidine, polyhexamethylene biguanide, or Citroxx: can chlorhexidine be replaced?”. Infection Control and Hospital Epidemiology7 (2010): 733-739.
  23. Lorenz K., et al. “Impact of different concentrations of an octenidine dihydrochloride mouthwash on salivary bacterial counts: a randomized, placebo-controlled cross-over trial”. Clinical Oral Investigations 22 (2018): 2917-2925.
  24. Pitten F A and Kramer A. “Antimicrobial efficacy of antiseptic mouthrinse solutions”. European Journal of Clinical Pharmacology2 (1999): 95-100.
  25. Grover V., et al. “Effect of octenidine mouthwash on plaque, gingivitis, and oral microbial growth: A systematic review”. Clinical and Experimental Dental Research 1 (2021): 1-15.
  26. Malanovic N., et al. “Octenidine: Novel insights into the detailed killing mechanism of Gram-negative bacteria at a cellular and molecular level”. International Journal of Antimicrobial Agents. 6 (2020): 1-9.
  27. Hübner NO., et al “Octenidine Dihydrochloride, a Modern Antiseptic for Skin, Mucous Membranes and Wounds”. Skin Pharmacology and Physiology 23 (2010): 244-258.
  28. Babalska ZL., et al. “Wound Antiseptics and European Guidelines for Antiseptic Application in Wound Treatment”. Pharmaceuticals 14 (2021): 1253.

Citation

Citation: Anamika. “Octenidine Dihydrochloride: A New Age Antimicrobial Agent".Acta Scientific Dental Sciences 7.7 (2023): 94-98.

Copyright

Copyright: © 2023 Anamika. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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Acceptance rate30%
Acceptance to publication20-30 days
Impact Factor1.278

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