Kuntalika Sarkar¹, Vathsala Naik², Gaurav Sharma³*, Aman Sodhi⁴ and Sabiha Tasneem Adud⁵

¹Post Graduate Student, Department of Oral Medicine and Radiology, Bangalore Institute of Dental Sciences and Hospital, Bangalore, India
²Professor and Head, Department of Oral Medicine and Radiology, Bangalore Institute of Dental Sciences and Hospital, Bangalore, India
³Associate Professor, Department of Oral Medicine and Radiology, Coorg Institute of Dental Sciences, Virajpet, Karnataka, India
⁴Professor, Department of Oral Medicine and Radiology, Bangalore Institute of Dental Sciences and Hospital, Bangalore, India
⁵House Surgeon, Bangalore Institute of Dental Sciences and Hospital, Bangalore, India

*Corresponding Author: Gaurav Sharma, Associate Professor, Department of Oral Medicine and Radiology, Coorg Institute of Dental Sciences, Virajpet, Karnataka, India.

Received: May 24, 2023; Published: May 31, 2023

Abstract

Developmental bioelectricity refers to the regulation of cell, tissue, and organ level patterning and behaviour as the result of endogenous electricity mediated signalling. Cells and tissues of all types use ion fluxes to communicate electrically. Bioelectric modulation has shown control over complex morphogenesis and remodelling, not just merely setting the individual cell identity.

With the advances in bio-engineering, multifunctional organic molecular devices with electric field sensing and modulation capability have been designed named as Twin bio-molecular intra cellular electro sensing device. The sensor module is derived from Tetraphenylethylene (TPE), which is a two photon fluorophore. The TPE sensor relies on the ultrafast photo-induced electron transfer (PeT) process to allow large changes in the electric field to be detected. The modulator module is an organic photoconductor, made of naphthalimide (NAI), whose resistivity can be tuned by using an ultraviolet optical source.

This Twin bio-molecular intra cellular electro sensing device, through cellular docking can be assessed and modulated to bring about homeostasis.

Keywords: Photoconductivity; Tetraphenylethylene (TPE); Naphthalimide (NAI); Bioelectricity; Fluorophore

References

1. Zhang Y., et al. “Multifunctional photoresponsive organic molecule for electric field sensing and modulation”. Journal of Materials Chemistry C (2022).
2. Chrysafides SM., et al. “Physiology, resting potential” (2022).
3. Wright SH. “Generation of resting membrane potential”. Advances in Physiology Education4 (2004): 139-142.
4. Moore AR., et al. “Spontaneous electrical activity in the human fetal cortex in vitro”. Journal of Neuroscience7 (2011): 2391-2398.
5. Reilly RB and Lee TC. “Electrograms (ecg, eeg, emg, eog)”. Technology and Health Care6 (2010): 443-458.
6. Soor NS., et al. “All-optical crosstalk-free manipulation and readout of Chronos-expressing neurons”. Journal of Physics D: Applied Physics10 (2019): 104002.
7. Boggess SC., et al. “New molecular scaffolds for fluorescent voltage indicators”. ACS Chemical Biology3 (2019): 390-396.
8. Liu P and Miller EW. “Electrophysiology, unplugged: imaging membrane potential with fluorescent indicators”. Accounts of Chemical Research1 (2019): 11-19.
9. Castaldelli E., et al. “Electrical semiconduction modulated by light in a cobalt and naphthalene diimide metal-organic framework”. Nature Communications1 (2017): 2139.

Citation

Citation: Gaurav Sharma., et al. “Twin Molecular Docking for Intra Cellular Electric Field Sensing and Modulation - A Literature Review - A New Concept in Therapeutics".Acta Scientific Dental Sciences 7.6 (2023): 66-68.

Copyright

Copyright: © 2023 Gaurav Sharma., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.