Kuntalika Sarkar1, Vathsala Naik2, Gaurav Sharma3*, Aman Sodhi4 and Sabiha Tasneem Adud5
1Post Graduate Student, Department of Oral Medicine and Radiology, Bangalore Institute of Dental Sciences and Hospital, Bangalore, India
2Professor and Head, Department of Oral Medicine and Radiology, Bangalore Institute of Dental Sciences and Hospital, Bangalore, India
3Associate Professor, Department of Oral Medicine and Radiology, Coorg Institute of Dental Sciences, Virajpet, Karnataka, India
4Professor, Department of Oral Medicine and Radiology, Bangalore Institute of Dental Sciences and Hospital, Bangalore, India
5House Surgeon, Bangalore Institute of Dental Sciences and Hospital, Bangalore, India
*Corresponding Author: Gaurav Sharma, Associate Professor, Department of Oral Medicine and Radiology, Coorg Institute of Dental Sciences, Virajpet, Karnataka, India.
Received: May 24, 2023; Published: May 31, 2023
Developmental bioelectricity refers to the regulation of cell, tissue, and organ level patterning and behaviour as the result of endogenous electricity mediated signalling. Cells and tissues of all types use ion fluxes to communicate electrically. Bioelectric modulation has shown control over complex morphogenesis and remodelling, not just merely setting the individual cell identity.
With the advances in bio-engineering, multifunctional organic molecular devices with electric field sensing and modulation capability have been designed named as Twin bio-molecular intra cellular electro sensing device. The sensor module is derived from Tetraphenylethylene (TPE), which is a two photon fluorophore. The TPE sensor relies on the ultrafast photo-induced electron transfer (PeT) process to allow large changes in the electric field to be detected. The modulator module is an organic photoconductor, made of naphthalimide (NAI), whose resistivity can be tuned by using an ultraviolet optical source.
This Twin bio-molecular intra cellular electro sensing device, through cellular docking can be assessed and modulated to bring about homeostasis.
Keywords: Photoconductivity; Tetraphenylethylene (TPE); Naphthalimide (NAI); Bioelectricity; Fluorophore
Citation: Gaurav Sharma., et al. “Twin Molecular Docking for Intra Cellular Electric Field Sensing and Modulation - A Literature Review - A New Concept in Therapeutics".Acta Scientific Dental Sciences 7.6 (2023): 66-68.
Copyright: © 2023 Gaurav Sharma., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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