Acta Scientific Dental Sciences (ASDS)(ISSN: 2581-4893)

Review Article Volume 7 Issue 6

A Review on Salivary Genomics in Oral Cancer

Mithlesh Solanki, Sangeeta R Patankar and Gokul Sridharan*

Department of Oral Pathology and Microbiology, Dr. G. D. Pol Foundation YMT Dental College and Hospital, Navi Mumbai, India

*Corresponding Author: Gokul Sridharan, Department of Oral Pathology and Microbiology, Dr. G. D. Pol Foundation YMT Dental College and Hospital, Navi Mumbai, India.

Received: May 08, 2023; Published: May 28, 2023


Oral cancer has emerged as a distressing health problem with increasing incidence and mortality rates all over the world. Early diagnosis and prompt treatment are the need of the hour to reduce the morbidity and mortality rate. The use of tumor biomarkers in disease diagnostics has garnered importance in recent times owing to advancements in technologies used for the identification of such biomarkers. OMICS technologies such as genomics, proteomics, transcriptomics and metabolomics have been used to detect various biomarkers in oral cancer and pre-cancer. The use of saliva for the identification of tumor biomarkers is promising owing to the ease of collection and the close proximity to the oral lesions. The present review highlights the importance of salivary genomic biomarkers in oral carcinogenesis.

Keywords: Oral Cancer; Salivary Diagnostics; Genomics; Oral Pre-Cancer


  1. Coelho KR. “Challenges of the Oral Cancer Burden in India”. Journal of Cancer Epidemiology (2012): 1-17.
  2. Borse V., et al. “Oral cancer diagnosis and perspectives in India”. Sensors International 1 (2020): 100046.
  3. Pereira T., et al. “Epidemiological trends of oral squamous cell carcinoma – An institutional study”. Muller Journal of Medical Sciences and Research1 (2021): 1.
  4. Pires FR., et al. “Oral squamous cell carcinoma: clinicopathological features from 346 cases from a single Oral Pathology service during an-8-year period”. Journal of Applied Oral Science5 (2013): 460-467.
  5. Vail M., et al. “Recognition of oral potentially malignant disorders and transformation to oral cancer”. Journal of the American Academy of Physician Assistants 11 (2020): 14-18.
  6. Ai R., et al. “Microenvironmental regulation of the progression of oral potentially malignant disorders towards malignancy”. Oncotarget46 (2017): 81617-81635.
  7. Hanahan D and Weinberg RA. “Hallmarks of Cancer: The Next Generation”. Cell 5 (2011): 646-674.
  8. Chakravarthi BV., et al. “Genomic and Epigenomic Alterations in Cancer”. American Journal of Pathology7 (2016): 1724-1735.
  9. Manzoni C., et al. “Genome, transcriptome and proteome: the rise of omics data and their integration in biomedical sciences”. Briefings in Bioinformatics 2 (2018): 286-302.
  10. Chakraborty S., et al. “Onco-Multi-OMICS Approach: A New Frontier in Cancer Research”. BioMed Research International (2018): 1-14.
  11. Kaliyappan K., et al. “Microarray and its applications”. Journal of Pharmacy and Bioallied Sciences6 (2012): 310.
  12. Llena-Puy C. “The rôle of saliva in maintaining oral health and as an aid to diagnosis”. Medicina Oral, Patologia Oral, Cirugia Bucal 11 (2006): E449-455.
  13. Javaid MA., et al. “Saliva as a diagnostic tool for oral and systemic diseases”. Journal of Oral Biology and Craniofacial Research 1 (2016): 67-76.
  14. Shah FD., et al. “A Review on Salivary Genomics and Proteomics Biomarkers in Oral Cancer”. Indian Journal of Clinical Biochemistry4 (2011): 326-334.
  15. Fabian T., et al. “Salivary Genomics, Transcriptomics and Proteomics: The Emerging Concept of the Oral Ecosystem and their Use in the Early Diagnosis of Cancer and other Diseases”. Current Genomics1 (2008): 11-21.
  16. Mishra A and Verma M. “Cancer Biomarkers: Are We Ready for the Prime Time?” Cancers1 (2010): 190-208.
  17. El-Naggar AK., et al. “Genetic Heterogeneity in Saliva from Patients with Oral Squamous Carcinomas”. The Journal of Molecular Diagnostics4 (2001): 164-170.
  18. Jiang W., et al. “Increased Mitochondrial DNA Content in Saliva Associated with Head and Neck Cancer”. Clinical Cancer Research7 (2005): 2486-2491.
  19. Nagata S., et al. “Aberrant DNA methylation of tumor-related genes in oral rinse”. Cancer17 (2012): 4298-4308.
  20. Pattani KM., et al. “Endothelin Receptor Type B Gene Promoter Hypermethylation in Salivary Rinses Is Independently Associated with Risk of Oral Cavity Cancer and Premalignancy”. Cancer Prevention Research9 (2010): 1093-1103.
  21. Guerrero-Preston R., et al. “NID2 and HOXA9 Promoter Hypermethylation as Biomarkers for Prevention and Early Detection in Oral Cavity Squamous Cell Carcinoma Tissues and Saliva”. Cancer Prevention Research7 (2011): 1061-1072.
  22. Ferlazzo N., et al. “Influence of MTHFR Genetic Background on p16 and MGMT Methylation in Oral Squamous Cell Cancer”. International Journal of Molecular Sciences 4 (2017): 724.
  23. Liyanage C ., et al. “Promoter Hypermethylation of Tumor-Suppressor Genes p16INK4a, RASSF1A, TIMP3, and PCQAP/MED15 in Salivary DNA as a Quadruple Biomarker Panel for Early Detection of Oral and Oropharyngeal Cancers”. Biomolecules4 (2019): 148.
  24. D’Cruz A., et al. “Non-Invasive Saliva-based Detection of Gene Mutations in Oral Cancer Patients by Oral Rub and Rinse Technique”. Asian Pacific Journal of Cancer Prevention10 (2021): 3287-3291.
  25. Mewara A., et al. “C-deletion mutation of the p53 gene at exon 4 of codon 63 in the saliva of oral squamous cell carcinoma in central India: a preliminary study”. Journal of Investigative and Clinical Dentistry 2 (2010): 108-113.
  26. Sun W., et al. “Detection of TIMP3 Promoter Hypermethylation in Salivary Rinse as an Independent Predictor of Local Recurrence-Free Survival in Head and Neck Cancer”. Clinical Cancer Research4 (2012): 1082-1091.
  27. Schussel J., et al. “EDNRB and DCC Salivary Rinse Hypermethylation Has a Similar Performance as Expert Clinical Examination in Discrimination of Oral Cancer/Dysplasia versus Benign Lesions”. Clinical Cancer Research12 (2013): 3268-3275.
  28. Fendt L., et al. “Profiling of Mitochondrial DNA Heteroplasmy in a Prospective Oral Squamous Cell Carcinoma Study”. Cancers7 (2020): 1933.
  29. Cui Y., et al. “Longitudinal detection of somatic mutations in saliva and plasma for the surveillance of oral squamous cell carcinomas”. PLoS ONE9 (2021): e0256979.
  30. Varun C, et al. “Salivary Her2/neu Levels in Differentiation of Oral Premalignant Disorders and Oral Squamous Cell Carcinomas”. Asian Pacific Journal of Cancer Prevention14 (2015): 5773-5777.
  31. Rosas, SLB., et al. “Promoter hypermethylation patterns of p16, O-methylguanine-DNA-methyltransferase and death associated protein kinase in tumors and saliva of head and neck cancer patients”. Cancer Research 61 (2001): 939-942.
  32. Righini CA ., et al. “Tumor-specific methylation in saliva: a promising biomarker for early detection of head and neck cancer recurrence”. Clinical Cancer Research4 (2007): 1179-1185.


Citation: Gokul Sridharan., et al. “A Review on Salivary Genomics in Oral Cancer".Acta Scientific Dental Sciences 7.6 (2023): 61-65.


Copyright: © 2023 Gokul Sridharan., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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