Ranya Ehab Hossam El Deen1, Ola Mohamed Ezzatt2 and Doaa Adel Khattab3
1Teaching Assistant of Oral Medicine, Oral Diagnosis and Periodontology, Misr International University, Egypt
2Assistant Professor of Oral Medicine, Periodontology and Oral Diagnosis, Faculty of Dentistry, Ain Shams University, Egypt
3Assistant Professor of Oral Medicine, Periodontology and Oral Diagnosis, Faculty of Dentistry, Ain Shams University, Egypt
*Corresponding Author: Doaa Adel Khattab, Assistant Professor of Oral Medicine, Periodontology and Oral Diagnosis, Faculty of Dentistry, Ain Shams University, Egypt.
Received: March 30, 2023; Published: April 28, 2023
Background: Periodontal disease is one of the most common oral diseases that affects the general public, although a number of surgical and pharmacological options are available for the the management of periodontitis yet it still affects a large proportion of population. Metformin is a second-generation biguanide anti-diabetic agent used to treat type II diabetes, Metformin has been used along with surgical and non-surgical periodontal therapy, as treatment for periodontitis. It has been reported to relieve clinical symptoms as BOP, PD and CAL. This study was carried out to investigate the clinical and microbiological effectiveness of 1% Metformin gel on Stage II grade B periodontitis. The rationale behind using Metformin is that it has a potential antimicrobial effect, also, It inhibits osteoclast formation and activity in periodontitis patients at the cellular level as well.
Method: a 37 year old female patient diagnosed with stage II grade B periodontitis, was treated with SRP combined with intrasulcular application of 1% Metformin gel at the deepest pocket of 5 mm PD and 4mm CAL and follow up period 6 months. GCF sample was collected at baseline and 2 weeks and RT-PCR was done to detect A.A and P.gingivalis at different time intervals.
Results. 1% Metformin gel improves the periodontal health with statistically significant improvement in the PPD, CAL, PI and GI values along with a significant decrease in all types of bacteria (A.A., P.gingivalis).
Conclusion: the use of 1% metformin gel as adjunct to non-surgical periodontal therapy (NSPT) provided a significant improvement in the clinical periodontal parameters in stage II grade B periodontitis and showed a statistically significant reduction in the bacteria load of (P.gingivalis ,T.pallidum, A.A. and P. intermedia) from baseline to 2 weeks and 2 months.
Keywords: Metformin; Periodontitis; Bacterial; PPD
Citation: Doaa Adel Khattab., et al. “Metformin Gel as Locally Delivered Adjunctive Therapy for Periodontitis Stage II, Grade B (A Randomized Controlled Clinical Trial with Quantitative Bacterial Assessment)".Acta Scientific Dental Sciences 7.5 (2023): 60-63.
Copyright: © 2023 Doaa Adel Khattab., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.