Acta Scientific Dental Sciences (ASDS)(ISSN: 2581-4893)

Research Article Volume 7 Issue 4

NanoTechnology, Regenerative Medicine and, Tissue Bio-Engineering

Omid PANAHI1*, Fatmanur KETENCİ ÇAY2 and Amirreza Ghanbary3

1Yeditepe university, Department of Oral and Maxillofacial Surgery, Istanbul, Turkey
2Yeditepe university, Department of Oral and Maxillofacial Radiology, Istanbul, Turkey
3Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, İran

*Corresponding Author: Omid PANAHI, Yeditepe university, Department of Oral and Maxillofacial Surgery, Istanbul, Turkey.

Received: March 03, 2023; Published: March 30, 2023


The appearance of regenerative medicine (RM) and tissue engineering (TE) opened new areas in medical science. This rapidly expanded field focuses on the restoring function of damaged tissues and organs. Due to their multidisciplinary identity, RM and TE are closely related to stem cell biology, cellular therapy, bioengineering and nanotechnology. Nanotechnology has provided new structures with unique biochemical, mechanical and electrical properties. With the advancement in nanotechnology, direct connection with cells has become possible, offering exciting medical therapy possibilities.

Keywords: Nanotechnology; Regenerative Medicine; Tissue Bioengineering


  1. Cui D J (2007): 1298.
  2. Pan B., et al. The Journal of Physical Chemistry C (2007): 12572-12576.
  3. Kami D and Gojo S. “Tuning cell fate: From insights to vertebrate regeneration”. Organogenesis2 (2014): 231-240.
  4. Slack JMW. “Stem cells in epithelial tissues”. Science5457 (2000): 1431-1433.
  5. La Noce M., et al. “Dental pulp stem cells: state of the art and suggestions for a true translation of research into therapy”. Journal of Dentistry 42 (2014): 761-768.
  6. Commission on Life Sciences. “Stem Cells and the Future of Regenerative Medicine”. Washington, DC: National Academy Press (2002).
  7. A Atala. “Advances in tissue and organ replacement”. Current Stem Cell Research and Therapy 3 (2008): 21-31.
  8. A Mendelson and PS Frenette. “Hematopoietic stem cell niche maintenance during homeostasis and regeneration”. Nature Medicine8 (2014): 833-846.
  9. Langer R and Vacanti JP. “Tissue Engineering”. Science 260 (1993): 920-926.
  10. Williams DF. “The Williams Dictionary of Biomaterials”. Liverpool, University Press, Liverpool (1993a).
  11. Akhyari P., et al. “Myocardial tissue engineering: The extra cellular matrix”. European Journal of Cardio-Thoracic Surgery 34 (2008): 229-241.
  12. Delaere P., et al. “Tracheal allotransplantation after withdrawal of immunosuppressive therapy”. New England Journal of Medicine 362 (2010): 138-145.
  13. Hamilton N., et al. “Tissue engineering airway mucosa: A systematic review”. Laryngoscope 124 (2014): 961-968.
  14. Jurj A., et al. “The new era of nanotechnology, an alternative to change cancer treatment”. Drug Design, Development and Therapy 11 (2017): 2871-2890.
  15. Alarc E., et al. “Recreating composition, structure, functionalities of tissues at nanoscale for regenerative medicine”. Regenerative Medicine 11 (2016): 849e58.
  16. Engel E., et al. “Nanotechnology in regenerative medicine: the materials side”. Trends in Biotechnology 26 (2008): 39-47.
  17. Mohammadian F., et al. “New state of nanofibers in regenerative medicine”. Artificial Cells, Nanomedicine, and Biotechnology 2 (2017): 204-210.
  18. Moonhyun Choi., et al. “Inkjet-based multilayered growth factor-releasing nanofilms for enhancing proliferation of mesenchymal stem cells in vitro”. Journal of Industrial and Engineering Chemistry 50 (2017): 36-40.
  19. Mohamed Mousa., et al. “Clay nanoparticles for regenerative medicine and biomaterial design: A review of clay bioactivity”. Biomaterials 159 (2018): 204-214.
  20. Stephanie Vial., et al. “Recent advances using gold nanoparticles as a promising multimodal tool for tissue engineering and regenerative medicine”. Current Opinion in Solid State and Materials Science 21 (2017): 92-112.
  21. Merkoc A. “Nanobiomaterials in electroanalysis”. Electroanalysis 19 (2007): 739-741.
  22. Hasirci V., et al. “Nanobiomaterials: a review of the existing science and technology, and new approaches”. Journal of Biomaterials Science, Polymer Edition 11 (2006): 1241-1268.
  23. Kumar P., et al. “The Chemo-Biological Outreach of Nano-Biomaterials: Implications for Tissue Engineering and Regenerative Medicine”. Current Pharmaceutical Design 24 (2017): 3538-3549.
  24. Bogunia-Kubik K and Sugisaka M. “From molecular biology to nanotechnology and nanomedicine”. Biosystems 2 (2002): 123-138.
  25. S Mclaughlin., et al. “Nano-Engineered Biomaterials for Tissue Regeneration: What Has Been Achieved So Far?” Frontiers in Materials 3 (2016): 1-28.
  26. S Das and AB Baker. “Biomaterials and Nanotherapeutics for Enhancing Skin Wound Healing”. Frontiers in Bioengineering and Biotechnology 4 (2016): 82.
  27. AP Tomsia., et al. “Nanotechnology Approaches for Better Dental Implants”. The International Journal of Oral and Maxillofacial Implants 26 (2011): 25-49.
  28. S Priyadarsini., et al. “Nanoparticles used in dentistry: A review”. Journal of Oral Biology and Craniofacial Research 1 (2018): 58-67.
  29. A Grumezescu. “Nanobiomaterials in Dentistry, Applications of Nanobiomaterials 11, 1st Edition”. William Andrew, Elsevier (2016): 498.
  30. Garg A. “Therapeutic applications of nanobiomaterials”. In: Novel Approaches for Drug Delivery (2016): 390.
  31. Rengan AK., et al. “In vivo analysis of biodegradable liposome gold nanoparticles as efficient agents for photothermal therapy of cancer”. Nano Letters 15 (2015): 842-848.
  32. MK Riley and W Vermerris. “Recent Advances in Nanomaterials for Gene Delivery-A Review”. Nanomaterials (Basel)5 (2017): 94.
  33. Sims NA and Martin TJ. “Coupling the activities of bone formation and resorption: a multitude of signals within the basic multicellular unit”. BoneKEy Reports (2014): 3.
  34. Ghosh P., et al. “Gold nanoparticles in delivery applications”. Advanced Drug Delivery Reviews 60 (2008): 1307-1315.
  35. Khan AK., et al. “Gold nanoparticles: synthesis and applications in drug delivery”. Tropical Journal of Pharmaceutical Research 13 (2014): 1169.
  36. Komatsu K., et al. “Alendronate promotes bone formation by inhibiting protein prenylation in osteoblasts in rat tooth replantation model”. Journal of Endocrinology 219 (2013): 145-158.
  37. LC Kennedy., et al. “A new era for cancer treatment: gold-nanoparticle-mediated thermal therapies”. Small 7 (2011): 169-183.
  38. AK Rengan., et al. “In vivo analysis of biodegradable liposome gold nanoparticles as efficient agents for photothermal therapy of cancer”. Nano Letters 15 (2015): 842-848.
  39. Hull CW. “Apparatus for production of three-dimensional objects by stereolithography”. US Patent575 (1986): 330.
  40. X Zhang and Y Zhang. “Tissue Engineering Applications of Three-Dimensional Bioprinting”. Cell Biochemistry and Biophysics 72 (2015): 777-782.
  41. ES Bishop., et al. “3-D bioprinting technologies in tissue engineering and regenerative medicine: current and future trends”. Genes Dislocation 4 (2017): 185-195.
  42. Murphy SV and Atala A. “3D bioprinting of tissues and organs”. Nature Biotechnology 8 (2014): 773-785.
  43. Boland T., et al. “Cell and organ printing 2: fusion of cell aggregates in threedimensional gels”. The Anatomical Record Part A Discoveries in Molecular Cellular and Evolutionary Biology 2 (2003): 497-502.
  44. Mohebi MM and Evans JR. “A drop-on-demand ink-jet printer for combinatorial libraries and functionally graded ceramics”. Journal of Combinatorial Chemistry 4 (2002): 267-274.
  45. Phillippi JA., et al. “Microenvironments engineered by inkjet bioprinting spatially direct adult stem cells toward muscle-and bone-like subpopulations”. Stem Cells 26 (2008): 127-134.
  46. Panwar A and Tan LP. “Current status of bioinks for microextrusion-based 3D bioprinting”. Molecules6 (2016): 685.
  47. Daniel L Cohen., et al. “Direct freeform fabrication of seeded hydrogels in arbitrary geometries”. Tissue Engineering 12 (2006): 1325-1335.
  48. Kevin Dzobo., et al. “Advances in Regenerative Medicine and Tissue Engineering: Innovation and Transformation of Medicine”. Stem Cells International (2018): 1-24.


Citation: Omid PANAHI., et al. “NanoTechnology, Regenerative Medicine and, Tissue Bio-Engineering".Acta Scientific Dental Sciences 7.4 (2023): 118-122.


Copyright: © 2023 Omid PANAHI., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Acceptance rate30%
Acceptance to publication20-30 days
Impact Factor1.278

Indexed In

News and Events

  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is April 30th, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

Contact US