Acta Scientific Dental Sciences (ASDS)(ISSN: 2581-4893)

Review Article Volume 7 Issue 4

Understanding Drug Delivery System for Safe Dispensing and Good Therapeutic Efficacy: A Review

Mahesh KP1* and Viveka S2

1Department of Oral Medicine and Radiology, Reader, JSS Dental College and Hospital, JSSAHER Mysore, India
2Postgraduate, Department of Oral Medicine and Radiology, JSS Dental College and Hospital, Mysore, India

*Corresponding Author: Mahesh KP, Department of Oral Medicine and Radiology, Reader, JSS Dental College and Hospital, JSSAHER Mysore, India.

Received: February 21, 2023; Published: March 13, 2023

Abstract

Pharmacology is the study of drugs, or chemical compounds, that act by interacting with different living things, such as cells, tissues, and even whole organisms, to achieve a desired result. A drug must enter the body and be distributed in some way that allows it to reach its site of action for it to be effective. The technique or approach used to provide pharmaceutical drugs to achieve therapeutic effect in people or animals is known as drug delivery. The creation of new materials or carrier systems for efficient therapeutic medication administration is a large area of study in the field of drug delivery. These systems are crucial in the treatment of many diseases. A novel drug's molecule requires expensive and time-consuming development. The employment of numerous methods, including dosage titration, individualising drug therapy, and therapeutic drug monitoring, improves the safety efficacy ratios of older medications. When it comes to delivering drugs to specific bodily regions, traditional methods of drug administration face several obstacles. To enhance the therapeutic delivery of medications, increasing research and development activities have been implemented, along with many investment opportunities. This article discusses the past background and conventional drug delivery methods. It also includes the update on some of the existing drug delivery technologies for oral controlled release, oral disintegrating dosage forms, and nano drug delivery system.

Keywords: Drug Delivery System; Therapeutics; Oral Controlled Release; Nanoparticles

References

  1. Park K. “Controlled drug delivery systems: past forward and future back”. Journal of Controlled Release 190 (2014): 3e8.
  2. Haesun Park., et al. “Evolution of drug delivery systems: From 1950 to 2020 and beyond”. Journal of Controlled Release 342 (2022): 53-65.
  3. AK Nayak and KK Sen. “Bone-targeted drug delivery systems”. in: S. Maiti, K.K. Sen (Eds.), Bio-Targets and Drug Delivery Approaches, CRC Press, Boca Raton, London (2016): 207231.
  4. AM Hillery and AS Hoffman. “Historical introduction to the field of controlled drug delivery”. in: A.M. Hillery, K. Park (Eds.), Drug Delivery: Fundamentals and Applications, Second edition, CRC Press, Boca Raton, FL (2016): 1-21.
  5. NA Peppas. “Historical perspective on advanced drug delivery: how engineering design and mathematical modeling helped the field mature”. Advanced Drug Delivery Reviews 65 (2013): 5-9.
  6. Kinam Park. “Controlled drug delivery systems: Past forward and future back”. Journal of Controlled Release 190 (2014): 3-8.
  7. Du and Chen. “Combination of drugs and carriers in drug delivery technology and its development”. Drug Design, Development and Therapy 13 (2019): 1401-1408.
  8. Chong Lia., et al. “Recent progress in drug delivery”. Acta Pharmaceutica Sinica B6 (2019): 1145e-1162.
  9. https://qu.edu.iq/den/wp-content/uploads/2015/10/Routes-of-adminstartion.pdf.
  10. Rawas-Qalaji M., et al. “Fast-disintegrating Sublingual Tablets: Effect of Epinephrine Load on Tablet Characteristics”. Pharmaceutical Science and Technology 2 (2006): 41.
  11. Gopal KS., et al. “Oral Bio Dissolving Films in Dentistry: A New Perspective in Treatment Modality” Medicine (2015).
  12. Zhang H., et al. “Oral mucosal drug delivery-clinical pharmacokinetics and therapeutic applications”. Clinical Pharmacokinetics 41 (2002): 661-680.
  13. Jyothi Rani L., et al. “Formulation and in vitro and in vivo evaluation of oral dispersible films of lornoxicam”. The Experiment 24 (2014): 1649-1655.
  14. Shivani A Chaudhari., et al. “REVIEW: CHOCOLATE FORMULATION AS DRUG DELIVERY SYSTEM”. Indian Journal of Drugs2 (2018): 136-141.
  15. Jassim ZE., et al. “Formulation and evaluation of fast dissolving film of lornoxicam”. Asian Journal of Pharmaceutical and Clinical Research 11 (2018): 217-223.
  16. Misal NV and Chemate SZ. “Formulation and evaluation of lornoxicam mouth dissolving tablet by using natural superdisintegrants”. International Journal of Pharmaceutical Sciences and Research4 (2019): 1848-1855.
  17. Mirza AZ and Siddiqui FA. “Nanomedicine and drug delivery: a mini review”. International Nano Letters 4 (2014): 94.
  18. , et al. “Nano based drug delivery systems: recent developments and future prospects”. Journal of Nanobiotechnology 16 (2018): 71.
  19. Lu H., et al. “Recent progress on nano‑ structures for drug delivery applications”. Journal of Nanomaterials (2016): 20.
  20. Kumari A., et al. “Nanotechnology: a tool to enhance therapeutic values of natural plant products”. Trends in Medical Research 7 (2012): 34-42.
  21. JJ Hirani., et al. “Orally disintegrating tablets: a review”. Tropical Journal of Pharmaceutical Research 2 (2009): 161172.
  22. S Sreenivas., et al. “Orodispersible tablets: new-fangled drug delivery system-a review”. Indian Journal of Pharmaceutical Education 4 (2005): 177.
  23. MA Wagh., et al. “Techniques used in orally disintegrating drug delivery system”. International Journal of Drug Delivery 2 (2010): 98107.
  24. Kyobula M., et al. “3D inkjet printing of tablets exploiting bespoke complex geometries for controlled and tuneable drug release”. Journal of Controlled Release 15 (2017): 207-261.
  25. American Pharmaceutical Review, 3D Printing in Personalized Drug Delivery (2021).
  26. Ma GJ and Wu CW. “Microneedle, bio-microneedle and bio-inspired microneedle: a review”. Journal of Controlled Release 23 (2017): 251-261.
  27. Tejashree Waghule., et al. “Microneedles: A smart approach and increasing potential for transdermal drug delivery system”. Biomedicine and Pharmacotherapy 109 (2019): 1249-1258.
  28. Abdelaziz HM., et al. “Inhalable particulate drug delivery systems for lung cancer therapy: nanoparticles, microparticles, nanocomposites and nanoaggregates”. Journal of Controlled Release 92 (2018): 269-374.
  29. Yi Lu., et al. “Injected nanocrystals for targeted drug delivery”. Acta Pharmaceutica Sinica B2 (2016): 106-113.
  30. Paolo Trucillo. Drug Carriers: Classification, Administration, Release Profiles, and Industrial Approach”. Processes 9 (2021): 470.
  31. Amit K Nayak., et al. “Drug delivery: present, past, and future of medicine”. Applications of Nanocomposite Materials in Drug Delivery (2018): 255-282.
  32. Du and Chen. “Combination of drugs and carriers in drug delivery technology and its development”. Drug Design, Development and Therapy 13 (2019): 1401-1408.

Citation

Citation: Mahesh KP and Viveka S. “Understanding Drug Delivery System for Safe Dispensing and Good Therapeutic Efficacy: A Review".Acta Scientific Dental Sciences 7.4 (2023): 32-39.

Copyright

Copyright: © 2023 Mahesh KP and Viveka S. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




Metrics

Acceptance rate30%
Acceptance to publication20-30 days
Impact Factor1.278

Indexed In





News and Events


  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is December 25, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"

Contact US









ff

© 2024 Acta Scientific, All rights reserved.