Acta Scientific Dental Sciences (ASDS)(ISSN: 2581-4893)

Research Article Volume 6 Issue 12

Oral Manifestations of Mucocutanous Disorders: Exploring Frequency and Oral Health-Related Quality of Life in Egyptian Cohort

Sherin Elsayed*, Wesam Abdel Moneim and Shereen Ali

Department of Oral Medicine and Peridontology, Faculty of Dentistry, Cairo University, Egypt

*Corresponding Author: Sherin Elsayed, Department of Oral Medicine and Peridontology, Faculty of Dentistry, Cairo University, Egypt.

Received: October 17, 2022; Published: November 15, 2022


Background: Literature studying the oral health-related quality of life (OHRQoL) among mucocutaneous disorders are limited. This study counted the frequency of oral manifestations among patients suffering from mucocutaneous disorders and assessed the effect of these oral manifestations on the OHRQoL using Oral Health Impact Profile-14 (OHIP-14).

Methods: The study included adult patients diagnosed with either pemphigus vulgaris (PV), mucous membrane pemphigoid (MMP), erythema multiforme (EM) or Stevens-Johnson syndrome (SJS). We documented patients with oral manifestations during the study and those with previous history. We measured the pain intensity using visual analogue scale (VAS) and OHRQoL by OHIP-14.

Results: Frequencies of oral manifestations were 75%, 62.9%, 76.6% and 26.6%, respectively, among MMP, PV, SJS and EM patients. Patients who reported history of oral manifestations were 18.75%, 9.8%, 6.7% and 22.2%, correspondingly. The frequency of females exceeded the males in all the disorders. MMP patients were the older, while SJS patients were the youngest. EM patients scored the highest VAS score, followed by SJS, then PV and MMP. Concerning OHIP-14 scores, EM scores were the highest followed by SJS, then MMP and PV interchangeably.

Conclusion: The frequency of oral manifestations was high among the studied disorders. Oral manifestations affected the OHRQoL severely, where EM and SJS are associated with the poorest OHRQoL.

Keywords:Mucocutaneous Disorders; Quality of Life; OHRQoL; MMP; PV; SJS; EM; OHIP-14


  1. Batistella Elis Ângela., et al. “Prevalence of oral mucosal lesions in patients with pemphigus vulgaris: A systematic review and meta-analysis”. Journal of Oral Pathology and Medicine: Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 8 (2021): 750-757.
  2. Calabria Elena., et al. “Autoimmune mucocutaneous blistering diseases in the south of Italy: a 25-year retrospective study on 169 patients”. Journal of Oral Pathology and Medicine: Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 7 (2020): 672-680.
  3. Chan YH. “Biostatistics 102: quantitative data--parametric and non-parametric tests”. Singapore Medical Journal8 (2003): 391-396.
  4. Chan YH. “Biostatistics 104: correlational analysis”. Singapore Medical Journal12 (2003): 614-619.
  5. Esatoglu, Sinem Nihal et al. “Behçet's syndrome: providing integrated care”. Journal of Multidisciplinary Healthcare10 (2017): 309-319.
  6. Farthing P., et al. “Mucosal disease series. Number IV. Erythema multiforme”. Oral Diseases5 (2005): 261-267.
  7. Fawzy Marwa Mohamed., et al. “Ear, nose, and throat involvement in Egyptian patients with pemphigus vulgaris: a step towards a better management”. International Journal of Dermatology10 (2013): 1268-1273.
  8. Hegarty AM., et al. “Patient-centred outcome measures in oral medicine: are they valid and reliable?”. International Journal of Oral and Maxillofacial Surgery6 (2002): 670-674.
  9. Hatemi Gulen., et al. “Considerations in designing and interpreting prevalence studies for Behçet syndrome”. Polish Archives of Internal Medicine3 (2018): 148-149.
  10. Huskisson, E C et al. “Application of visual-analogue scales to the measurement of functional capacity”. Rheumatology and Rehabilitation15,3 (1976): 185-187.
  11. Kalinska-Bienias Agnieszka., et al. “Measuring of quality of life in autoimmune blistering disorders in Poland. Validation of disease - specific Autoimmune Bullous Disease Quality of Life (ABQOL) and the Treatment Autoimmune Bullous Disease Quality of Life (TABQOL) questionnaires”. Advances in Medical Sciences1 (2017): 92-96.
  12. Krain Rebecca L., et al. “Assessing the Correlation Between Disease Severity Indices and Quality of Life Measurement Tools in Pemphigus”. Frontiers in Immunology10 (2016): 2571.
  13. Leuci Stefania., et al. “Oral autoimmune vesicobullous diseases: Classification, clinical presentations, molecular mechanisms, diagnostic algorithms, and management”. Periodontology 20001 (2019): 77-88.
  14. Ni Riordain R., et al. “Impact of chronic oral mucosal disease on daily life: preliminary observations from a qualitative study”. Oral Diseases3 (2011): 265-269.
  15. Ní Ríordáin, Rícheal., et al. “World Workshop on Oral Medicine VI: Patient-reported outcome measures and oral mucosal disease: current status and future direction”. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology2 (2015): 152-160.e11.
  16. Paradisi, Andrea et al. “Quality-of-life assessment in patients with pemphigus using a minimum set of evaluation tools”. Journal of the American Academy of Dermatology2 (2009): 261-269.
  17. Petersen Poul Erik., et al. “The global burden of oral diseases and risks to oral health”. Bulletin of the World Health Organization9 (2005): 661-669.
  18. Petersen Poul Erik. “The World Oral Health Report 2003: continuous improvement of oral health in the 21st century--the approach of the WHO Global Oral Health Programme”. Community Dentistry and Oral Epidemiology1 (2003): 3-23.
  19. Petersen Poul Erik. “Global policy for improvement of oral health in the 21st century--implications to oral health research of World Health Assembly 2007, World Health Organization”. Community Dentistry and Oral Epidemiology1 (2009): 1-8.
  20. Rajan Bijina., et al. “Assessment of quality of life in patients with chronic oral mucosal diseases: a questionnaire-based study”. The Permanente Journal1 (2014): e123-127.
  21. Rashid Hanan., et al. “Oral Lesions in Autoimmune Bullous Diseases: An Overview of Clinical Characteristics and Diagnostic Algorithm”. American Journal of Clinical Dermatology6 (2019): 847-861.
  22. Riva Fedrico., et al. “Adult oral health-related quality of life instruments: A systematic review”. Community Dentistry and Oral Epidemiology5 (2022): 333-338.
  23. Saleh Marwah Adly., et al. “Assessment of the quality of life of Egyptian and Tunisian autoimmune bullous diseases' patients using an Arabic version of the autoimmune bullous disease quality of life and the treatment of autoimmune bullous disease quality of life questionnaires”. Anais Brasileiros de Dermatologia4 (2019): 399-404.
  24. Scully C and D H Felix. “Oral medicine--update for the dental practitioner. Mouth ulcers of more serious connotation”. British Dental Journal6 (2005): 339-343.
  25. Slade GD and A J Spencer. “Development and evaluation of the Oral Health Impact Profile”. Community Dental Health1 (1994): 3-11.
  26. Sung Jae Yong., et al. “Quality of Life Assessment in Korean Patients with Pemphigus”. Annals of Dermatology5 (2015): 492-498.


Citation: Sherin Elsayed., et al. “Oral Manifestations of Mucocutanous Disorders: Exploring Frequency and Oral Health-Related Quality of Life in Egyptian Cohort".Acta Scientific Dental Sciences 6.12 (2022): 60-72.


Copyright: © 2022 Sherin Elsayed., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Acceptance rate30%
Acceptance to publication20-30 days
Impact Factor1.278

Indexed In

News and Events

  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is April 30th, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

Contact US