Nitya Jha¹*, Harsita Chhajer¹, Sree Chandana Shreya Sivalanka¹ and Jhanvi Solanki²

¹Department of Oral Medicine and Radiology, NSVK Sri Venkateshwara Dental College and Hospital, Bengaluru, Affiliated to Rajiv Gandhi University of Health Sciences, Karnataka, India
²Department of Oral Medicine and Radiology, Karnavati University, India

*Corresponding Author: Nitya Jha, Department of Oral Medicine and Radiology, NSVK Sri Venkateshwara Dental College and Hospital, Bengaluru, Affiliated to Rajiv Gandhi University of Health Sciences, Karnataka, India.

Received: August 11, 2022; Published: August 26, 2022

Abstract

Background: Over the last few decades our understanding of the molecular basis of tumour pathology has greatly improved and as science and technology is growing beyond mankind’s yet explored fathoms, it is but imperative for us to utilize these new approaches to try and change the age-old methods of cancer diagnosis. Through these studies we have gained an insight into the world of molecular biomarkers and specific target therapies which are currently been developed. Moreover the use of saliva as a bio-fluid for these studies has been significant to highlight the non-invasive approach to detect these biomarkers. The advancement of these omic studies have also called in for more specific and sensitive research techniques. The purpose of this review is to highlight the importance of salivary biomarkers the proteomes and transcriptomes in early cancer diagnosis and to pave the way for better conceptualising the ideologies of the proteomics and the transcriptomics world.

Aim of the Study: To determine the significance of Salivary Proteomes and Transcriptomes in the field of cancer diagnosis.

Research Question: Are salivary proteomes and transcriptomes significant in supporting early cancer diagnosis?

Materials and Methods: The study sample included review and research articles based on databases from the COCHRANE collaboration as well as few other scientific libraries like Medline and Med-know, having undergone a definite Randomized Control Trial (RCT), to signify the title of the study. Various inclusion and exclusion criterion for Systematic Review decided the final RCT based research articles for the study. (For the given study there were 65 articles which were selected out of which 45 were chosen post having undergone Randomised Control Trial).

Keywords: Oral Cancer; Proteomics; Transcriptomics; Saliva

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Citation

Citation: Nitya Jha., et al. “Human Salivary (Biomarkers) Proteome and Transcriptome: A Boon in Modern Cancer Diagnosis- A Systematic Review". Acta Scientific Dental Sciences 6.9 (2022): 66-75.

Copyright

Copyright: © 2022 Nitya Jha., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.