Acta Scientific Dental Sciences (ISSN: 2581-4893)

Mini Review Volume 6 Issue 8

Nikolsky’s Sign: A Diagnostic Blessing?

Srinivas Prasad Vijayan 1 and Anitha Krishnan Pandarathodiyil 2*

1Faculty of Dentistry, Kusum Devi Sunderlal Dugar Jain Dental College and Hospital, Kolkata, West Bengal, India
2Associate Professor, Faculty of Dentistry, SEGi University, Jalan Teknologi, Kota Damansara, Selangor, Malaysia

*Corresponding Author: Anitha Krishnan Pandarathodiyil, Associate Professor, Faculty of Dentistry, SEGi University, Jalan Teknologi, Kota Damansara, Selangor, Malaysia.

Received: July 18, 2022; Published: July 26, 2022


Nikolsky’s sign, a term coined in honour of a renowned Russian dermatologist, is a well-known clinical manifestation that is primarily elicited in the pemphigus group of disorders. Although it is seen in other dermatological conditions like Staphylococcal Scalded Skin Syndrome (SSSS), Epidermolysis Bullosa (EB), Stevens-Johnson syndrome (SJS), Oral Lichen Planus (OLP) and Toxic Epidermal Necrolysis (TEN), it is characteristically associated with and seen in the pemphigus group of diseases, most notably pemphigus vulgaris (PV). A characteristic clinical feature seen in PV is the separation of the epidermis from the dermis on application of pressure on the skin with a sliding/pressing motion. The etio-pathogenesis, histopathology, clinical variants and their significance are briefly discussed in this short communication.

Keywords: Pemphigus; Nikolsky’s Sign; Acantholysis; Intraepidermal Cleft


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Citation: Srinivas Prasad Vijayan and Anitha Krishnan Pandarathodiyil. “Nikolsky’s Sign: A Diagnostic Blessing?". Acta Scientific Dental Sciences 6.8 (2022): 94-97.


Copyright: © 2022 Srinivas Prasad Vijayan and Anitha Krishnan Pandarathodiyil. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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