Acta Scientific Dental Sciences (ISSN: 2581-4893)

Mini Review Volume 6 Issue 8

Nikolsky’s Sign: A Diagnostic Blessing?

Srinivas Prasad Vijayan 1 and Anitha Krishnan Pandarathodiyil 2*

1Faculty of Dentistry, Kusum Devi Sunderlal Dugar Jain Dental College and Hospital, Kolkata, West Bengal, India
2Associate Professor, Faculty of Dentistry, SEGi University, Jalan Teknologi, Kota Damansara, Selangor, Malaysia

*Corresponding Author: Anitha Krishnan Pandarathodiyil, Associate Professor, Faculty of Dentistry, SEGi University, Jalan Teknologi, Kota Damansara, Selangor, Malaysia.

Received: July 18, 2022; Published: July 26, 2022

Abstract

Nikolsky’s sign, a term coined in honour of a renowned Russian dermatologist, is a well-known clinical manifestation that is primarily elicited in the pemphigus group of disorders. Although it is seen in other dermatological conditions like Staphylococcal Scalded Skin Syndrome (SSSS), Epidermolysis Bullosa (EB), Stevens-Johnson syndrome (SJS), Oral Lichen Planus (OLP) and Toxic Epidermal Necrolysis (TEN), it is characteristically associated with and seen in the pemphigus group of diseases, most notably pemphigus vulgaris (PV). A characteristic clinical feature seen in PV is the separation of the epidermis from the dermis on application of pressure on the skin with a sliding/pressing motion. The etio-pathogenesis, histopathology, clinical variants and their significance are briefly discussed in this short communication.

Keywords: Pemphigus; Nikolsky’s Sign; Acantholysis; Intraepidermal Cleft

References

  1. Moss C and Gupta E. “The Nikolsky sign in staphylococcal scalded skin syndrome”. Archives of Disease in Childhood 79 (1998): 290.
  2. Sachdev D. “Sign of Nikolsky and related signs”. Indian Journal of Dermatology, Venereology and Leprology 69 (2003): 243‑24
  3. Michael D Martin. “Gingival Nikolsky's Sign is Useful for Clinical Diagnosis”. Journal of Evidence-Based Dental Practice 9 (2009): 217-218.
  4. Goodman H. “Nikolsky sign: page from notable contributors to the knowledge of dermatology”. AMA Archives of Dermatology and Syphilology 3 (1953): 334-335.
  5. Hacham-Zadeh S and Even-Paz Z. “A Modified Technique for Eliciting Nikolsky's Sign”. Archives of Dermatological 2 (1980): 160.
  6. Soni AG. “Nikolsky's sign - A clinical method to evaluate damage at epidermal-dermal junction”. Journal of Indian Academy of Oral Medicine and Radiology 30 (2018): 68-72.
  7. Coelho LK., et al. “Esophageal Nikolsky’s sign in pemphigus vulgaris”. Endoscopy 29 (1997): S35.
  8. Sagher F., et al. “Nikolsky sign on cervix uteri in pemphigus”. British Journal of Dermatology 90 (1974): 407‑4
  9. Urbano FL. “Nikolsky’s sign in autoimmune skin disorders”. Hospital Physician 37 (2001): 23‑2
  10. Barzegari M., et al. “Microscopic Nikolsky’s sign: Is it useful for diagnosis of pemphigus vulgaris?” Iranian Journal of Dermatology 2 (2008): 64‑68.
  11. Grando SA., et al. “History and clinical significance of mechanical symptoms in blistering dermatoses: A reappraisal”. Journal of the American Academy of Dermatology 48 (2003): 86‑
  12. Polifka M and Krusinski PA. “The Nikolsky sign”. Cutis 26 (1980): 521‑
  13. Doubleday CW. “Who is Nikolsky and what does his sign mean?” Journal of the American Academy of Dermatology 16 (1987): 1054‑105
  14. Seshadri D., et al. “Acantholysis revisited: Back to basics”. Indian Journal of Dermatology, Venereology and Leprology 79 (2013): 220‑2
  15. Neviile BW., et al. “Oral and Maxillofacial Pathology”. 2nd India: W.B Saunders Company (2010).

Citation

Citation: Srinivas Prasad Vijayan and Anitha Krishnan Pandarathodiyil. “Nikolsky’s Sign: A Diagnostic Blessing?". Acta Scientific Dental Sciences 6.8 (2022): 94-97.

Copyright

Copyright: © 2022 Srinivas Prasad Vijayan and Anitha Krishnan Pandarathodiyil. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




Metrics

Acceptance rate30%
Acceptance to publication20-30 days
Impact Factor1.278

Indexed In





News and Events


  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is December 25, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"

Contact US









ff

© 2024 Acta Scientific, All rights reserved.