Fatale Alisa¹, Leibovitz Haviv Shirley² and Zilberman Uri³*

¹Chief resident, Pediatric Dental Clinic, Barzilai Medical University Center, Ashkelon, Affiliated to Ben-Gurion University, Beer-Sheva, Israel
²Instructor, Pediatric Dental Clinic, Barzilai Medical University Center, Ashkelon, Affiliated to Ben-Gurion University, Beer-Sheva, Israel
³Head of the Pediatric Dental Clinic, Pediatric Dental Clinic, Barzilai Medical University Center, Ashkelon, Affiliated to Ben-Gurion University, Beer-Sheva, Israel

*Corresponding Author: Zilberman Uri, Head of the Pediatric Dental Clinic, Pediatric Dental Clinic, Barzilai Medical University Center, Ashkelon, Affiliated to Ben-Gurion University, Beer-Sheva, Israel.

Received: May 17, 2022; Published: June 09, 2022

Abstract

Objectives: To analyze dental development and mineralization of teeth from girls affected by congenital CMV.

Materials and Methods: Deciduous and permanent dentitions of three girls with congenital CMV infection were analyzed. X-rays and plaster impressions were taken during routine dental treatment. MD dimensions of the deciduous and permanent teeth were performed using a digital caliper and compared to teeth size of normal girls. On deciduous teeth of one girl, the relative content of elements in enamel and dentin were analyzed and compared to normal girls.

Results: The MD dimensions of the deciduous teeth and the early developing permanent teeth showed true microdontia (mean-2SD). The relative concentration of elements in both enamel and dentin showed hypomineralization and increased organic ions concentration.

Conclusions: Congenital CMV affect the development and mineralization of deciduous and permanent teeth. The teeth showed true microdontia and hypomineralization.

Clinical Relevance: True microdontia as observed in deciduous and early erupting permanent teeth in girls affected by congenital CMV, is due to smaller tooth germ. Clinical and orthodontic evaluation and treatment are necessary in order to obtain a normal occlusion. The hypomineralization may pose a higher carious risk for the children affected by congenital CMV.

Keywords: Cytomegalovirus (CMV); Microdontia; Hypomineralization; Tooth Germ

References

1. Weller TH. “The cytomegaloviruses: ubiquitous agents with protean clinical manifestations I”. The New England Journal of Medicine 285 (1971a): 203-214.
2. Dollard SC., et al. “New estimates of the prevalence of neurogical and sensory sequelae and mortality associated with congenital cytomegalovirus infection”. Review of Medical Virology 17 (2007): 355-363.
3. Ross DS., et al. “The epidemiology and prevention of congenital cytomegalovirus infection and isease: activities of the Centers for Disease Control and Prevention Workgroup”. Journal of Women's Health (Larchmt) 15 (2006): 224-229.
4. Weller TH. “The cytomegaloviruses: ubiquitous agents with protean clinical manifestations. II”. The New England Journal of Medicine 285 (1971b): 267-274.
5. Stagno S., et al. “Defects of tooth structure in congenital cytomegalovirus infection”. Pediatrics 69 (1982): 646-648.
6. Jaskoll T., et al. “Cytomegalovirus induces stage-dependent enamel defects and misexpression of amelogenin, enamelin and dentin sialophosphoprotein in developing mouse molars”. Cells Tissues Organs 192 (2010): 221-239.
7. Divya DV., et al. “The serological evidence of cytomegalovirus infection as a potent aetiological factor for cleft lip/palate, mental retardation and deafness”. Journal of Clinical and Diagnostic Research 11 (2017): ZC51-ZC54.
8. Jaskoll T., et al. “Cytomegalovirus inhibition of embryonic mouse tooth development: A model of the human amelogenesis imperfecta phenocopy”. Archives of Oral Biology 53 (2008): 405-415.
9. Stewart RE., et al. General concepts of growth and development”. In: RE Stewart, TK Barber, KC Troutman and SHY Wei (eds). “Pediatric Dentistry-Scientific foundations and clinical practice”. The C.V. Mosby Company (1982): 19.
10. Shafer WG., et al. Developmental disturbances of oral and paraoral structures. In: WG Shafer, MK Hine, BM Levy (eds). “A Textbook of Oral Pathology 3^rd edition”. W.B. Saunders Co (1974): 34-48.
11. Morrees CFA., et al. “Mesiodistal crown diameters of the deciduous and permanent teeth in individuals”. Journal of Dental Research 36 (1956): 39-47.
12. Steigman S., et al. “Relationship between mesiodistal crown diameter of posterior deciduous and succedaneous teeth in Israeli children”. European Journal Orthodontic 4 (1982): 219-227.
13. Koch G and Thesleff I. “Developmental disturbances in number and shape of teeth and their treatment”. In: Koch G, Poulsen S (eds). Pediatric dentistry, a clinical approach. 2^nd edition”. Chichester, UK: Wiley-Blackwell (2013): 191.
14. Bargale SD and Kiran SD. “Non-syndromic occurrence of true generalized microdontia with mandibular mesiodens - a rare case”. Head and Face Medicine7 (2011): 19.
15. Opinya GN., et al. “Oral findings in Fanconi's anemia. A case report”. Journal of Periodontology 59 (1998): 461-463.
16. Villa A., et al. “Hypodontia and microdontia: clinical features of a rare syndrome”. Journal of the Canadian Dental Association 77 (2011): b115.

Citation

Citation: Zilberman Uri., et al. “The Effect of Congenital Cytomegalovirus on Tooth Development and Mineralization". Acta Scientific Dental Sciences 6.7 (2022): 07-14.

Copyright

Copyright: © 2022 Zilberman Uri., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.