Dr. Bharani Krishna .T M.D.S¹*, Dr. Mohammad Naffizuddin M.D.S², Dr. K Madhu Kiran Naik M.D.S³, Dr. Deepika Vasudevan M.D.S⁴, Dr. Kilaru Naveen Babu⁵, Dr. Kanaka Durga Devi Nelluri⁶, V Sridevi⁷ and Chaitanya Krishna.T MS⁸

¹Assistant Professor, Department of Oral Medicine and Radiology, Dr. N.T.R University of Health Sciences, Vijayawada, Andhra Pradesh, India ²Assistant Professor, Department of Oral and Maxillofacial Surgery, Dr.N.T.R University of Health Sciences, Vijayawada, Andhra Pradesh, India ³Assistant Professor, Department of Conservative Dentistry and Endodontics, Dr.N.T.R University of Health Sciences, Andhra Pradesh, India ⁴Assistant Professor, Department of Periodontics, Dr. N.T.R University of Health Sciences, Hyderabad, India ⁵Professor, Department of Pharmaceutics and Biotechnology, KVSR Siddhartha College of Pharmaceutical Sciences,Vijayawada, Andhra Pradesh, India ⁶Professor, Department of Pharmaceutics and Biotechnology, KVSR Siddhartha College of Pharmaceutical Sciences,Vijayawada, Andhra Pradesh, India ⁷Lab Technician, KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada Andhra Pradesh, India ⁸Teesside University, Middlesbrough, England, UK

*Corresponding Author: Bharani Krishna, Assistant Professor, Department of Oral Medicine and Radiology, Dr. N.T.R University of Health Sciences, Vijayawada, Andhra Pradesh, India.

Received: April 26, 2022; Published: May 16, 2022

Abstract

Corticosteroids are therapeutic drugs used in the management of various diseases. They are vastly used in the field of medicine for treating chronic diseases. Steroids act as drugs of choice when the rest of the drugs failed in the due course of the management of illness. Even during the Covid-19 pandemic steroids stood as hope for treatment. Corticosteroids always act as a cure for chronic diseases despite their known Adverse effects. They always stand as hope for the clinician in restoring the health and vigour of the patient. In this article, we shall discuss corticosteroids and their applications in the management of chronic diseases in medicine and dentistry.

Keywords: Corticosteroids; Glucocorticoids; Mineralocorticoids

References

1. Cooper MS and Stewart PM. “11Beta-hydroxysteroid dehydrogenase type 1 and its role in the hypothalamus pituitary-adrenal axis, metabolic syndrome, and inflammation”. The Journal of Clinical Endocrinology and Metabolism 94 (2009): 4645-4654.
2. Kumar R and Thompson EB. “Gene regulation by the glucocorticoid receptor: structure: function relationship”. The Journal of Steroid Biochemistry and Molecular Biology 94 (2005): 383-394.
3. Bledsoe RK., et al. “Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition”. Cell 110 (2002): 93-105. 
4. Grad I and Picard D. “The glucocorticoid responses are shaped by molecular chaperones”. Molecular and Cellular Endocrinology 275 (2007): 2-10. 
5. Pratt WB and Toft DO. “Steroid receptor interactions with heat shock protein and immunophilin chaperones”. Endocrine Reviews 18 (1997): 306-360. 
6. Beato M. “Gene regulation by steroid hormones”. Cell 56 (1989): 335-344. 
7. Freedman LP. “Anatomy of the steroid receptor zinc finger region”. Endocrine Reviews 13 (1992): 129-145. 
8. Surjit M., et al. “Widespread negative response elements mediate direct repression by agonist-liganded glucocorticoid receptor”. Cell 145 (2011): 224-241.
9. Hudson WH., et al. “The structural basis of direct glucocorticoid-mediated transrepression”. Nature Structural and Molecular Biology 20 (2013): 53-58. 
10. John S., et al. “Chromatin accessibility pre- determines glucocorticoid receptor binding patterns”. Nature Genetics 43 (2011): 264-268.

Citation

Citation: Bharani Krishna., et al. “Corticosteroids-The Life-Saving Drugs in Chronic Diseases". Acta Scientific Dental Sciences 6.6 (2022): 83-92.

Copyright

Copyright: © 2022 Bharani Krishna., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.