Acta Scientific Dental Sciences (ASDS)(ISSN: 2581-4893)

Review Article Volume 6 Issue 5

B Cells in Periodontitis - A Friend or Foe?

Dr. Bhalchandra Bhausaheb Thorat*, Dr. Mala Dixit Baburaj, Pradnya Dattatraya Kadam and Sandeep K Pmiple

Department of Periodontics, Nair Hospital and Dental College, India

*Corresponding Author: Dr. Bhalchandra Bhausaheb Thorat, Department of Periodontics, Nair Hospital and Dental College, India.

Received: April 05, 2022; Published: April 26, 2022


It is evident that B lymphocytes and Plasma cells superior among cells in periodontitis. Despite the fact that T cells work as the principal regulatory group of cells, B cells seem to have several critical roles in periodontitis. The capacity of B cells to demonstrate class II antigens and contribute to antigen presentation has been revealed in periodontal diseases. Different subtypes of B cells, such as B-1a and B-2 cells are present in periodontal lesions. Increased level of B-1a cells has been reported in subjects with severe forms of periodontitis. B-1a cells have been associated with interleukin-10 and this cytokine serves as an autocrine growth factor for this type of B cell. Despite the fact that microbial antigens are associated with the initiation of the inflammatory responses in periodontitis, endogenous antigens also play a part in the chronicity of periodontal disease.

Keywords: Periodontitis; B Cells; T Cells; Bone Loss


  1. Jonsson R., et al. “Immunoglobulin isotype distribution of locally produced autoantibodies to collagen type I in adult periodontitis. Relationship to periodontal treatment”. Journal of Clinical Periodontology 18 (1991): 703-707.
  2. Berglundh T., et al. “B cells in periodontitis- friends or enemies?” Periodontology 45 (2007): 51-66.
  3. Viau M and M Zouali. “B-lymphocytes, innate immunity, and autoimmunity”. Clinical Immunology 114 (2005): 17-26.
  4. Hikada M and M Zouali. “Multistoried roles for B lymphocytes in autoimmunity”. Nature Immunology 11 (2010): 1065-1068.
  5. Zouali M. “Tweaking the B lymphocyte compartment in autoimmune diseases”. Nature Immunology 15 (2014): 209-212.
  6. Zouali M and Y Richard. “Marginal zone B-cells, a gatekeeper of innate immunity”. Frontiers in Immunology 2 (2011): 63.
  7. Sugawara M., et al. “Detection of, and anti-collagen antibody produced by, CD5-positive B cells in inflamed gingival tissues”. Journal of Periodontology Research 27 (1992): 489-498.
  8. Afar B., et al. “Activated lymphocyte subsets in adult periodontitis”. Journal of Periodontal Research 27 (1992): 126-133.
  9. Tabeta K., et al. “Elevated humoral immune response to heat shock protein 60 (hsp60) family in periodontitis patients”. Clinical and Experimental Immunology 120 (2000): 285-293.
  10. Albandar JM., et al. “Cigar, pipe, and cigarette smoking as risk factors for periodontal disease and tooth loss”. Journal of Periodontology 71 (2000): 1874-1881.
  11. Berglundh T., et al. “The presence of local and circulating autoreactive B cells in patients with advanced periodontitis”. Journal of Clinical Periodontology 29 (2002): 281-286.
  12. Aramaki M., et al. “Presence of activated B-1 cells in chronic inflamed gingival tissue”. Journal of Clinical Immunology 18 (1998): 421-429.
  13. O’Garra A., et al. “Ly-1 B (B-1) cells are the main source of B cell-derived interleukin 10”. European Journal of Immunology 22 (1992): 711-717.
  14. Berglundh T., et al. “Some effects of periodontal therapy on local and systemic immunological parameters”. Journal of Clinical Periodontology 26 (1999): 9.
  15. Donati M., et al. “B-1a cells in experimental gingivitis in humans”. Journal of Periodontology 80 (2009): 1141-1145.
  16. Manilay JO and M Zouali. “Tight relationships between B lymphocytes and the skeletal system”. Trends in Molecular Medicine 20 (2014): 405-412.
  17. Yasuda H., et al. “A novel molecular mechanism modulating osteoclast differentiation and function”. Bone 25 (1999): 109-113.
  18. Li Y., et al. “B cells and T cells are critical for the preservation of bone homeostasis and attainment of peak bone mass in vivo”. Blood 109 (2007): 3839-3848.
  19. . “Relationship between Educational Level and Incidence of Obesity among Adults in Abeokuta, Ogun State, Nigeria". Acta Scientific Medical Sciences8 (2020): 136-142.


Citation: Dr. Bhalchandra Bhausaheb Thorat., et al. “B Cells in Periodontitis - A Friend or Foe?”. Acta Scientific Dental Sciences 6.5 (2022): 102-107.


Copyright: © 2022 Dr. Bhalchandra Bhausaheb Thorat., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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