Acta Scientific Dental Sciences (ASDS)(ISSN: 2581-4893)

Review Article Volume 6 Issue 3

Bone Grafts – A Valuable Substitute for Replacing Bony Defects- A Review

Pradeep C Dathan1, Deepak Nallaswamy2, S Rajeshkumar3, Suja Joseph14, Shahin Ismail5 and K Chandrasekharan Nair6*

1Professor and Head of the Department of Prosthodontics, Sri Sankara Dental College, Akathumuri, Thiruvavananthapuram, Kerala, India
2Director, Department of Prosthodontics, Saveetha Dental College, Chennai, India
3Chief Scientist, Nanobiomedicine Lab, Dept. of Pharmacology, Saveetha Dental College, Chennai, India
4Professor, Department of Prosthodontics, Pushpagiri College of Dental Sciences, Thiruvalla, Kerala, India
5Reader, Department of Prosthodontics, Sri Sankara Dental College, Akathumuri, Thiruvavananthapuram, Kerala, India
6Professor Emeritus, Department of Prosthodontics, Sri Sankara Dental College, Akathumuri, Thiruvavananthapuram, Kerala, India

*Corresponding Author: K Chandrasekharan Nair, Professor Emeritus, Department of Prosthodontics, Sri Sankara Dental College, Akathumuri, Thiruvavananthapuram, Kerala, India.

Received: March 04, 2022; Published: March 15, 2022

Abstract

Numerous graft materials are in use of which autografts are considered as a gold standard. Autografts have the uniqueness of having osteogenic, osteoinductive and osteoconductive potential. At the same time, they have well identified disadvantages too which include donor site morbidity, graft availability and the risk of disease transmission. Synthetic graft substitutes do not have osteoinductive or osteogenic properties. Composite grafts are also being used effectively for osteogenesis. The limited availability of suitable bone grafts has ushered in the era of tissue engineering for bone repair. Additive manufacturing, also known as 3D printing, is considered as an ideal method for orthopedic applications such as bone grafting. Here in this review the scope of bone grafts and graft substitutes used for different clinical applications is discussed.

Keywords: Bone Graft; Bone Graft Substitute; Autografts; Allografts; Xenografts; Alloplast; Mesenchymal Cells

References

  1. SU Meghana Gajavalli., et al. “Bone Substitutes used in Implant Dentistry”. TPDI2 (2018).
  2. Y Fillingham and J Jacobs. “Bone grafts and their substitutes”. Bone and Joint Journal 98-100 (2016).
  3. Peter V Giannoudis., et al. “Bone substitutes: An update”. Injury-international Journal of the Care of the Injured (2005) 36S, S20-S27
  4. Thomas W Bauer and George F Muschler. “Bone graft materials An overview of basic science”. Clinical Orthopaedics and Related Research Number 321 10-27.
  5. Håvard Jostein Haugen., et al. “Bone grafts: which is the ideal biomaterial?” Journal of Clinical Periodontology 21 (2019): 92-102.
  6. Timothy T Robertsa and Andrew J. “Bone grafts, bone substitutes and orthobiologics”. Rosenbauma a Division of Orthopaedic Surgery; Albany Medical Center; Albany, NY USA Published online (2012).
  7. Smiler D and Soltan M. “The Bone Grafting Decision Tress: A Systematic Methodology for Achieving New Bone”. Implant Dentistry2 (2006).
  8. S Titsinides., et al. “Bone grafting materials in dentoalveolar reconstruction A comprehensive review”. Japanese Dental Science Review 55 (2019): 26-32.
  9. Vasilis T Athanasiou., et al. “Histological comparison of autograft, allograft-DBM, xenograft, and synthetic grafts in a trabecular bone defect: An experimental study in rabbits”. Medical Science Monitor 1 (2010): BR24-31.
  10. Arun K Garg. “Bone Biology, Harvesting, Grafting for Dental Implants Rationale and Clinical Applications”. ©2004 Quintessence Publishing Co, Inc.
  11. Prasanna Kumar., et al. “Bone grafts in dentistry”. Journal of Pharmacy and Bioallied Sciences 5 (2013).
  12. AysegulAtasoy and Gamze Torun Kose. “Biology of Cancellous Bone Graft Materials and their Usage for Bone Regeneratio”. JSM Biotechnology and Biomedical Engineering 2 (2016): 1051.
  13. Gordon Carter RN. “Harvesting and Implanting Allograft Bone”. AORN Journal4 (1999).
  14. Fedirico Hernandez Alfaro. “Grafting in Oral Implantology Techniques and Clinical Applications©”. 2006 Quintessence Publishing Co.Ltd. (UK) (2006).
  15. Giacomo Tarquini. “Treatment of Intrabony Defects Using Equine-derived Bone Granules and Collagen Membranes: A Retrospective Study with a 13-year Follow-up Giacomo Tarquini”. The Journal of Contemporary Dental Practice9 (2020).
  16. Roshni Ramesh and Arun Sadasivan. “Comparative evaluation of the physical and chemical properties of three different aloplastic bone graft materials used in periodontal bone regeneration”. International Journal of Current Research09 (2017): 57220-57222.
  17. William G., et al. “Bone Grafts and Bone Graft Substitutes in Orthopaedic Trauma Surgery A Critical Analysis”. The Journal of Bone and Joint Surgery 89-a.3 (2007).
  18. Chen Yang., et al. “Physical/Chemical Properties and Resorption Behavior of a Newly Developed Ca/P/S-Based Bone Substitute Material”. Materials 13 (2010): 3458.
  19. , et al. “Physicochemical properties of hydroxyapatite/montmorillonite nanocomposite prepared by powder sintering”. Results in Physics 15 (2019): 102540.
  20. Alberto Monjea and Hom-Lay Wanga. “Biological and physical properties of bone block grafting biomaterials for alveolar ridge augmentation”. Journal of Oral Science and Rehabilitation1 (2017): 18-30.
  21. Patricia Janicki and Gerhard Schmidmaier. “What should be the characteristics of the ideal bone graft substitute? Combining scaffolds with growth factors and/or stem cells”. Injury-International Journal of the Care of the Injured 42 (2011): S77-S81.
  22. Daniel Gonc., et al. “Cell Culture-Based Tissue Engineering as an Alternative to Bone Grafts in Implant Dentistry: A Literature Review”. Journal of Oral Implantology 38 (2012).
  23. Mirjam Fröhlich., et al. “Tissue Engineered Bone Grafts: Biological Requirements, Tissue Culture and Clinical Relevance”. Current Stem Cell Research and Therapy 4 (2008): 254-264.
  24. , et al. “Bone graft substitutes”. Expert Review of Medical Devices 3.1 (2006) 49-57.
  25. Ryan Trombetta., et al. “3D Printing of Calcium Phosphate Ceramics for Bone Tissue Engineering and Drug Delivery”. Annals of Biomedical Engineering1 (2016): 23-24.
  26. Shailly H Jariwala., et al. “3D Printing of Personalized Artificial Bone Scaffolds”. Mary Ann Liebert, inc 2.2 (2015).
  27.  

Citation

Citation: Pradeep C Dathan., et al. “Bone Grafts – A Valuable Substitute for Replacing Bony Defects -A Review". Acta Scientific Dental Sciences 6.3 (2022): 42-53.

Copyright

Copyright: © 2022 K Chandrasekharan Nair., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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