Quevedo Bisonni M*, Sciaini Lewis V, Nuñez Otero M, Rodriguez K and Suárez JM

Oral Surgery Department, Faculty of Medicine and Dentistry, University of Santiago de Compostela, Spain

*Corresponding Author: Quevedo Bisonni M, Oral Surgery Department, Faculty of Medicine and Dentistry, University of Santiago de Compostela, Spain.

Received: July 27, 2021; Published: August 26, 2021

Citation: Quevedo Bisonni M., et al. “Application of the Platelet Rich Fibrin and L-PRF Leucocytes Technique in Long-Standing Periapical and Periodontal Lesion Defects". Acta Scientific Dental Sciences 5.9 (2021): 143-151.

Abstract

  Long-standing periapical and periodontal lesions present a common biological sequence, progressive resorption and loss of alveolar bone around the affected tooth. In recent years there has been an enormous evolution in the key role that platelets play in tissue regeneration techniques, facilitating, among other actions, the healing of soft tissues and hard tissues thanks to the release of cytokines and growth factors over an extended period of time. Platelets rich in fibrin and leukocytes is a second generation platelet concentrate, which we obtain without additives directly from the patient's blood with the aim of establishing a fibrin mesh that serves as an anchor to all the substances involved in the tissue regeneration process.

Keywords: Platelet Rich Fibrin; L-PRF Leucocytes Technique; Periodontal Lesion Defects

Bibliography

1. Baiju RM., et al. “Autologous platelet-rich fibrin: A boon to periodontal regeneration. Report of two different clinical applications”. Health Sciences (2013): 1-13.
2. Gupta V., et al. “Regenerative potential of platelet rich fibrin in dentistry: Literature review”. The Asian Journal of Oral Health and Allied Sciences 1 (2011): 22-28.
3. Caballero A., et al. “Bone regeneration of the alveolar ridge with platelet-rich fibrin before implant placement. A clinical case”. Spanish Journal of Implants (2017).
4. Dohan Ehrenfest DM., et al. “Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte-and platelet-rich fibrin (L-PRF)”. Trends in Biotechnology 27 (2009): 158-167.
5. Salgado A., et al. “New trends in tissue regeneration: fibrin rich in platelets and leukocytes”. Revista Española de Cirugía Oral y Maxilofacial 39 (2017): 91-98.
6. Madurantakam P., et al. “Characterization of Leukocyte-platelet rich fibrin. A novel biomaterial”. Journal of Visualized Experiments 29 (2015): 10.
7. Preeja C and Arun S. “Platelet-rich fibrin: Its role in periodontal regeneration”. The Saudi Journal for Dental Research 5 (2014): 117-122.
8. Jeong SM., et al. “Simultaneous sinus lift and implantation using platelet- rich fibrin as sole grafting material”. Journal of Cranio-Maxillofacial Surgery 42 (2014): 990-994.
9. Oncu E and Kaymaz E. “Assessment of the effectiveness of platelet rich fibrin in the treatment of Schneiderian membrane perforation”. Clinical Implant Dentistry and Related Research (2017): 1-6.
10. Xuan F., et al. “A comparative study of the regenerative effect of sinus bone grafting with platelet-rich fibrin-mixed Bio-Oss® and commercial fibrin-mixed Bio-Oss®: an experimental study”. Journal of Cranio-Maxillofacial Surgery4 (2014): e47-50.
11. Ozgul O., et al. “Efficacy of platelet rich fibrin in the reduction of the pain and swelling after impacted third molar surgery: Randomized multicenter split-mouth clinical trial”. Head and Face Medicine 11 (2015): 37.
12. Leigha R. “Potential of platelet rich fibrin in regenerative periodontal therapy: literature review”. Canadian Journal of Dental Hygiene1 (2013): 33-37.
13. Anitua E., et al. “Infiltration of plasma rich in growth factors enhances in vivo angiogenesis and improves reperfusion and tissue remodeling after severe hind limb ischemia”. Journal of Controlled Release 202 (2015): 31-39.
14. McLellan J and Plevin S. “Temporal release of growth factors from platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) in the horse: A comparative in vitro analysis”. The International Journal of Applied Research in Veterinary Medicine 12 (2014): 44-53.
15. Arce MA., et al. “Fibrin rich in platelets and leukocytes: Excellent autologous biomaterial for tissue regeneration (2018).
16. Moreno Díez R., et al. “Techniques for obtaining platelet-rich plasma and its use in osteoinductive therapy”. Farmacia Hospitalaria3 (2015): 130-136.
17. Chenchev IL., et al. “Application of platelet-rich fibrin and injectable platelet rich fibrin in combination of bone substitute material for alveolar ridge augmentation - case report”. Folia Medica 59 (2017): 362-366.
18. Cortese A., et al. “Platelet-rich fibrin (PRF) in implant dentistry in combination with new bone regenerative technique in elderly patients”. International Journal of Surgery Case Reports 28 (2016): 52-56.
19. Mateos L., et al. “Periodontal surgical techniques applied to implantology”. Advances in Periodontics 2 (2003): 57-68.
20. Dohan-Ehrenfest DM., et al. “The impact of the centrifuge characteristics and centrifugation protocols on the cells, growth factors and fibrin architecture of a leukocyte- and platelet-rich fibrin (L-PRF) clot and membrane. Part 1: Evaluation of the vibration shocks of 4 models of table centrifuges for L-PRF”. Possessed 2 (2014): 129-139.
21. Choukroun J., et al. “Une opportunité in paro-implantology: thePRF”. Implantodontie 42 (2001): 55-62.
22. Giannini S., et al. “Comparison between PRP, PRGF and PRF: Lights and shadows in three similar but different protocols”. European Review for Medical and Pharmacological Sciences 19 (2015): 92730.
23. Khorshidi H., et al. “Comparison of the mechanical properties of early leukocyte-and platelet-rich fibrin versus PRGF / endoret membranes”. International Journal of Dentistry (2016): 1849207.
24. Del Corso M., et al. “Current knowledge and perspectives for the use of platelet-rich plasma (PRP) and platelet-rich fibrin (PRF).
25. Solomiya K., et al. “Combination of an allogenic and a xenogenic bone substitue material with injectable platelet-rich fibrin- A comparative in vitro study”. The Journal of Biomaterials Applications (2020).
26. De Almeida Barros Mourão CF., et al. “The use of leukocyte- and platelet-richfibrin in the management of soft tissue healing and pain in post-extraction sockets: A randomized clinical trial”. Journal of Cranio-Maxillofacial Surgery (2020).
27. Law B., et al. “Autogenous free fat graft combined with platelet-rich fibrin heals a refractory mandibular osteoradionecrosis”. Clinical Therapeutics2 (2020): e110-e113.
28. Fan Y., et al. “Clinical Uses of Platelet-Rich Fibrin in Oral and Maxillofacial Surgery”. Dental Clinics of North America2 (2020): 291-303.
29. Bi J., et al. “Platelet-rich Fibrin Improves the Osteo-/Odontogenic Differentiation of Stem Cells from Apical Papilla via the Extracellular Signal-regulated Protein Kinase Signaling Pathway”. The Journal of Endodontics (2020).
30. Temmerman A., et al. “Theuse of Leucocyte and platelet-rich fibrin in socket management and ridge preservation: a split – mouth, randomized, controlled clinical trial”. Journal of Clinic Periodontology (2016).
31. De Angelis P., et al. “Hard and Soft Tissue Evaluation of Different Socket Preservation Procedures Using Leukocyte and Platelet-Rich Fibrin: A Retrospective Clinical and Volumetric Analysis”. Journal of Oral and Maxillofacial Surgery9 (2019): 1807-1815.
32. P Dragonas., et al. “Effects of leukocyte–platelet-rich fibrin (L-PRF) in different intraoral bone grafting procedures: a systematic review”. International Journal of Oral and Maxillofacial Surgery2 (2019): 250-262.
33. Bielecki T., et al. “The Role of Leukocytes from L-PRP/L-PRF in Wound Healing and Immune Defense: New Perspectives”. Current Pharmaceutical Biotechnology 13 (2012): 1153.
34. Pan J., et al. “Effect of platelet-rich fibrin on alveolar ridge preservation”. Journal of the American Dental Association9 (2019): 766-778.

Copyright: © 2021 Quevedo Bisonni M., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.