Acta Scientific Dental Sciences (ISSN: 2581-4893)

Research ArticleVolume 5 Issue 9

Comparative Analyses of Dense and Porous Chitosan-Xanthan Membranes

Fabio Alessandro Simões1*, Antonio Carlos Aloise2 and Lydia Masako Ferreira3

1DDS, MSc, Surgical Translational Graduate Program at UNIFESP, São Paulo, SP, Brazil
2DDS, MSc, PhD, UNIFESP, São Paulo, SP, Brazil
3MD, PhD, Head and Full Professor Plastic Surgery Division UNIFESP, Researcher CNPq 1A, Director Translational Surgery Graduate Program UNIFESP, São Paulo, SP, Brazil

*Corresponding Author: Fabio Alessandro Simões, DDS, MSc, Surgical Translational Graduate Program at UNIFESP, São Paulo, SP, Brazil.

Received: July 03, 2021; Published: : August 19, 2021

Citation: Fabio Alessandro Simões, et al. “Comparative Analyses of Dense and Porous Chitosan-Xanthan Membranes". Acta Scientific Dental Sciences 5.9 (2021): 81-88.


Introduction: Polymeric materials are often used in tissue engineering to foster the growth and/or healing of the most varied types of tissues and organs.

Objective: To analyze the physicochemical properties of porous chitosan-xanthan membranes.

Method: Chitosan-xanthan membranes were prepared through complexation of the polysaccharides Chitosan (Ch) and Xanthan (Xn) in a 1:1 mass ratio solution. The compact membranes (Control Group - CG) were obtained by modeling the polysaccharide complex onto polystyrene plates. Porous membranes (Experimental Group - EG) were obtained by adding Pluronic® F127 to the polysaccharide complexes immediately before modeling onto the polystyrene plates. The membranes were characterized by analyzing the morphology, thickness, absorption, and degradation rates in aqueous (H2O) and 0.9% NaCl (SS) solutions, as well as the mechanical resistance (maximum stress and elongation at rupture) of the Control and Experimental groups.

Results: For the CG and EG, the thickness of wet membranes was 2.39 ± 0.27mm and 2.69 ± 0.46mm, respectively (p > 0.05). Regarding water and saline absorption capacity, CG displayed 70.13 ± 3.77g and 28.92 ± 0.55g, respectively, and the EG 28.72 ± 0.91g and 15.21 ± 0.59g, respectively (p < 0.05). The mass variation of CG membranes exposed to water and saline solution was 12.85 ± 0.41% and 8.79 ± 1.40%, respectively, and for EG 16.13 ± 0.19% and 25.06 ± 0.99%, respectively (p < 0.05). The maximum stress at rupture of the CG and EG membranes was 0.03 ± 0.01 MPa and 0.05 ± 0.03 MPa, respectively (p < 0.05). The elongation at rupture of CG and EG membranes was 54.02 ± 16.45% and 50.86 ± 11.94%, respectively.

Conclusion: Porous chitosan/xanthan membranes showed less absorption of water and saline solution, greater variation in mass and greater resistance to tearing, when compared to compact membranes.

Keywords: Chitosan; Xanthan; Tissue Engineering; Scaffolds; Artificial Membranes; Support Tissue


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Copyright: © 2021 Fabio Alessandro Simões, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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