Acta Scientific Dental Sciences (ISSN: 2581-4893)

Research ArticleVolume 5 Issue 6

Bisphosphonates Related Osteonecrosis of the Jaw: Systematic Review of the Literature

SM Bouzoubaa, Mahad Chaimae*, S Ait Lhaj and I Benyahya

Oral Surgery Department, Dental Consultation and Treatment Center, Ibn Rochd University Hospital Center, Casablanca, Morocco

*Corresponding Author: Mahad Chaimae, Oral Surgery Department, Dental Consultation and Treatment Center, Ibn Rochd University Hospital Center, Casablanca, Morocco.

Received: April 12, 2021; Published: : May 21, 2021

Citation: Mahad Chaimae., et al. “Bisphosphonates Related Osteonecrosis of the Jaw: Systematic Review of the Literature". Acta Scientific Dental Sciences 5.6 (2021): 104-111.

Abstract

Objectives: The aim of this review is to assess the route of administration of bisphosphonates (BPs) most likely to generate osteonecrosis of the jaw (ONJ) while determining the profile of patients receiving this type of treatment.

Methods: A literature search in PubMed, EMBASE and Cochrane of randomized controlled clinical trials, systematic reviews and meta-analyzes was carried out between 2007 and 2018 using the terms bisphosphonates (BPs), oral, intravenous and osteonecrosis of the jaws.

The number of publications by year, type of publication and level of proof of the articles were assessed. Likewise, the incidences of occurrence of ONJ according to each route of administration of BPs and the profile of patients receiving this treatment were identified.

Results: 3456 publications published since 2007, mainly in oncology and maxillofacial journals, were reviewed. 6 publications whose level of proof corresponds to our objective were selected.

Discussion: Studies have shown a wide variety in design and a strong incidence of ONJ depending on the route of administration of Bps. A higher prevalence has been observed following intravenous administration.

Keywords: Osteonecrosis of the Jaw; Bisphosphonates; Oral Route; Venous Route

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Copyright: © 2021 Mahad Chaimae., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



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