Abstract

  Linear IgA disease is a non hereditary, autoimmune sub epidermal bullous disease, characterized by the presence of linear deposition of IgA auto antibodies along the basement membrane zone. The disease has a bimodal occurrence, manifesting in both children and adults. The cause is usually obscure in childhood, although, adult onset cases are primarily due to drugs (vancomycin), malignancies and infections. Skin and several mucous membrane involvement usually occur, and oral lesions are rarely seen in the disease. Dapsone forms the mainstay of treatment along with corticosteroids.

Keywords: Dapsone; Desquamative Gingivitis; Immunofluorescence; Linear IgA Disease; Subepithelial Blistering

References

1. Hasan S., et al. “Desquamative Gingivitis as a Sign in Mucous Membrane Pemphigoid- A Case Report and Review of Literature”. International Journal of Contemporary Dentistry1 (2012): 30-37.
2. Van der Waal RI., et al. “Linear IgA bullous dermatosis in a patient with renal cell carcinoma”. British Journal of Dermatology 144 (2001): 870-873.
3. Eguia del Valle A., et al. “Oral manifestations caused by linear IgA disease”. Medicina Oral 9 (2004): 39-44.
4. Freedberg IM., et al. “Fitzpatrick’s Dermatology in General Medicine”. New York 6th edition. McGraw-Hill. (2003).
5. Joseph TI., et al. “Linear IgA dermatosis adult variant with oral manifestation: a rare case report”. Journal of Oral and Maxillofacial Pathology 1 (2015): 83-87.
6. Wenning VA. “Linear IgA disease: Clinical presentation, diagnosis, and pathogenesis”. Immunology and Allergy Clinics of North America 32 (2012): 245-253.
7. Thokchom N and Pamei D. “Linear IgA bullous dermatosis”. Journal of Medical Society 28 (2013): 80-81.
8. Fortuna G and Marinokovich MP. “Linear immunoglobulin A bullous dermatosis”. Clinical Dermatology 30 (2012): 38-50.
9. Wojnarowska F., et al. “Chronic bullous disease of childhood, childhood cicatricial pemphigoid and linear IgA disease of adults. A comparative study demonstrating clinical and immunopathological overlap”. Journal of the American Academy of Dermatology 19 (1988): 792-805.
10. Visentainer L., et al. “Vancomycin-induced linear IgA bullous dermatosis (LABD)-an atypical presentation”. Clinical Case Reports5 (2019): 1091-1093.
11. Patsatski A. “Chronic bullous disease or Linear IgA dermatosis of Childhood-Revisited”. Journal of Genetics and Gene Therapy 4 (2013): 6.
12. Greenberg MS and Glick M. In: Burket’s Oral Medicine Diagnosis and Treatment 11th Edition. BC Decker, New York (2008).
13. Wakelin SH., et al. “Drug induced linear IgA disease with antibodies to collagen VII”. British Journal of Dermatology 138 (1998): 310-314.
14. Combemale P., et al. “Dermatose a IgA lineaire (DIAL) induite par penicilline G”. Annales de Dermatologie et de Vénéréologie 120 (1993): 847-848.
15. Shimanovich I., et al. “Localized linear IgA disease induced by ampicillin/sulbactam”. Journal of the American Academy of Dermatology 51 (2004): 95-98.
16. Kelly SE., et al. “A clinicopathological study of mucosal involvement in linear IgA disease”. British Journal of Dermatology 119 (1998): 161-170.
17. Talhari C., et al. “Successful treatment of linear IgA disease with mycophenolate mofetil as a corticosteroid sparing agent”. Clinical and Experimental Dermatology 30 (2005): 297-298.
18. Rose C., et al. “Histopathology of anti-p200 pemphigoid”. American Journal of Dermatopathology 2 (2007): 119-124.
19. Egan CA and Zone JJ. “Linear IgA bullous dermatosis”. International Journal of Dermatology 38 (1999): 818-827.
20. Godfrey K., et al. “Linear IgA disease of adults: association with lymphoproliferative malignancy and possible role of other triggering factors”. British Journal of Dermatology 123 (1990): 447-452.
21. Plemons J., et al. “Vesicullobullous diseases of the oral cavity”. Periodontology 21 (2000): 158-175.
22. Gameiro A., et al. “Vancomycin induced linear IgA bullous drematosis: associations”. Dermatology Online Journal4 (2016): 4-9.
23. Kang MJ., et al. “Vancomycin-induced IgA bullous dermatosis: a reare case report and review of the literature”. Annals of Dermatology2 (2008): 102-106.
24. Guide SV and Marinokovich MP. “Linear IgA bullous dermatoses”. Clinical Dermatology 19 (2001): 719-727.
25. Chen S., et al. “Linear IgA bullous dermatoses”. Eplasty 13 (2013): 49.
26. Angiero F., et al. “Rare case of desquamative gingivitisdue to linear IgA diseas: Morphological and immunofluorescent features”. In vivo 21 (2007): 1093-1098.
27. Verma R., et al. “Linear IgA disease in an adult with unusual clinical features”. Indian Dermatology Online Journal 4 (2013): 115-118.
28. Hasan S. “Desquamative gingivitis-A clinical sign in mucous membrane pemphigoid: Report of a case and review of literature”. Journal of Pharmacy and Bioallied Sciences 2 (2014): 122-126.
29. Wojnarowska F., et al. “Immunobullous diseases”. In: Rook's Textbook of dermatology. 7th ed. Burns T, Breathnach S, Cox N and Griffiths C (eds.). Blackwell Science: Oxford (2004): 41-53.
30. Wilson BD., et al. “Linear IgA bullous dermatosis. An immunologically defined disease”. International Journal of Dermatology 9 (1985): 569-574.
31. Aoki V., et al. “Direct and indirect immunofluorescence”. Anais Brasileiros de Dermatologia 85 (2010): 490-500.
32. Hasan S., et al. “Mucous membrane pemphigoid with exclusive gingival involvement: Report of a case and review of literature”. Journal of Orofacial Sciences1 (2012): 64-69.
33. Cohen LM., et al. “Infectious vesiculobullous and vesiculopustular diseases”. In: Elder D, Elenitsas R, Jaworsky C., et al. Levers’s Histopathology of skin”. 8th edition. Lippincott: Raven Publishers (1997): 235-37.
34. Hasan S., et al. “Erythema multiforme: A Recent update”. Biomedical and Pharmacology Journal . 1 (2018): 167-170.
35. Dabrowski J., et al. “The ultrastructural localization of IgA deposits in chronic bullous disease of childhood (CBDC)”. Journal of Investigative Dermatology 72 (1979): 291-295.
36. Prost C., et al. “Diagnosis of adult Linear IgA dermatosis by immunoelectron microscopy in 16 patients with linear IgA deposits”. Journal of Investigative Dermatology 92 (1989): 39-45.
37. O’Regan E., et al. “Linear IgA disease presenting as desquamative gingivitis”. Archives Of Otolaryngology–Head and Neck Surgery 130 (2004): 469-472.
38. Satchell AC and St Barnetson RC. “Linear IgA disease: successful treatment with cyclosporin”. British Journal of Dermatology 143 (2000): 204-205.

Citation

Citation: Shamimul Hasan. “Linear IgA Disease - A Rare Sub Epithelial Disorder: A Current Appraisal". Acta Scientific Dental Sciences 4.10 (2020): 100-104.

Copyright

Copyright: © 2020 Shamimul Hasan. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.