Abstract

 Oral cancer is one of the major health issues in India. The traditional risk factors or oral cancer include pan chewing, tobacco and alcohol use. However, Human papillomavirus (HPV) 16 is now being implicated causing oral cancer. Until recent times, the research on oral cancer has focused on factors like genetics, evolving lifestyle and environmental factors such as pollution. The possible etiological role of HPV16 and 18 in oral oncogenesis needs to be addressed. Additionally, there are many aspects of HPV in causation of oral cancer that still needs to be understood and addressed. The following chapter focuses on types and role of HPV, its pathogenesis within the oral cavity, and prognosis in case of HPV-positive cancer cases. The chapter also includes an update on the diagnostic tests, with highlight on various specific biomarkers, and the treatments developed to contain the HPV-positive cancer cases. Current research areas and future perspectives have been covered in this chapter which can be taken up to advance the research on HPV-positive oral cancer.

Keywords: Human Papillomavirus (HPV); Oral Cancer; Oncogenic Viruses; Tobacco

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Citation

Citation: Smitha T. “Role of HPV in Oral Cancer". Acta Scientific Dental Sciences 4.8 (2020): 117-127.

Copyright

Copyright: © 2020 Smitha T. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.