Acta Scientific Dental Sciences (ISSN: 2581-4893)

Research Article Volume 4 Issue 8

A Case of Sinonasal Lymphoepithelial Carcinoma Presenting as a Palatal Swelling pdf/ASDS

Nikolaos Kolomvos1, Dionysios Kyrmizakis2, Evangelia Piperi3 and Evanthia Chrysomali3*

1Department of Oral and Maxillofacial Surgery, School of Dentistry, National and Kapodistrian University of Athens, Greece
2Otorhinolaryngology Head and Neck Surgery, Heraklion Hospital, Greece
3Department of Oral Medicine and Pathology, School of Dentistry, National and Kapodistrian University of Athens, Greece

*Corresponding Author: Evanthia Chrysomali, Department of Oral Medicine and Pathology, School of Dentistry, National and Kapodistrian University of Athens, Greece.

Received: June 29, 2020; Published: July 25, 2020



Lymphoepithelial carcinoma is a rare type of undifferentiated carcinoma, characterized by atypical epithelial cells surrounded by a reactive lymphoplasmacytic infiltrate. We report a case of sinonasal lymphoepithelial carcinoma arising in the left maxillary sinus in an 80-year-old Caucasian male patient. The lesion had invaded the adjacent lateral wall of the nasal cavity appearing on the palate as a painful swelling. There was no evidence of tumor involvement from the nasopharynx and larynx assessment and no swollen cervical lymph nodes were noticed on the head and neck imaging examination. An incisional biopsy from the oral cavity, as well as an endoscopic biopsy of the neighboring nasal mass were performed. The histopathological and immunohistochemical analysis of both specimens showed identical features and a common diagnosis of sinonasal lymphoepithelial carcinoma was rendered. In conclusion, oral swellings located on the palate may be associated with maxillary sinus malignancies. Thus, the clinician should include in the differential diagnosis not only primary oral carcinomas, but also malignant neoplasms arising from neighboring anatomic sites.

Keywords: Lymphoepithelial Carcinoma; Maxillary Sinus; Palate; Sinonasal



  1. Franchi A., et al. “Data Set for the Reporting of Carcinomas of the Nasal Cavity and Paranasal Sinuses: Explanations and Recommendations of the Guidelines from the International Collaboration on Cancer Reporting”. Archives of Pathology and Laboratory Medicine 4 (2019): 424-431.
  2. Mohammed D., et al. “Lymphoepithelial carcinoma in the maxillary sinus: a case report”. Journal of Medical Case Report416 (2012): 1-4.
  3. Muthayam SR., et al. “Lymphoepithelial carcinoma arising from the maxillary antrum: a clinicopathological report of a rare lesion in an unusual site”. Quantitative Imaging in Medicine and Surgery 6 (2014): 512-515.
  4. Rytkönen AE., et al. “Lymphoepithelial carcinoma: two case reports and a systematic review of oral and sinonasal cases”. Head and Neck Pathology 5 (2011): 327-334.
  5. Hajiioannou JK., et al. “Nasopharyngeal-type undifferentiated carcinoma (lymphoepithelioma)”. Journal of Otolaryngology 2 (2006): 147-151.
  6. Almeida LY., et al. “EBV-negative lymphoepithelial-like carcinoma of the lower lip”. Autopsy Case Report 10 (2020): e138.
  7. Zhan KY., et al. “Lymphoepithelial carcinoma of the major salivary glands: Predictors of survival in a non-endemic region”. Oral Oncology (2016): 24-29.
  8. Han AJ., et al. “Lymphoepithelioma-like carcinoma of the lung with a better prognosis. A clinicopathologic study of 32 cases”. The American Journal Clinical Pathology6 (2001): 841-850.
  9. Takakura H., et al. “Lymphoepithelial carcinoma of the maxillary sinus. A case report and review of the literature”. Medicine 28 (2018): e11371.
  10. Zong Y., et al. “Epstein-Barr virus infection of sinonasal lymphoepithelial carcinoma in Guangzhou”. Chinese Medical Journal2 (2001): 132-136.
  11. Jeng YM., et al. “Sinonasal undifferentiated carcinoma and nasopharyngeal-type undifferentiated carcinoma: two clinically, biologically, and histopathologically distinct entities”. American Journal of Surgical Pathology 3 (2002): 371–376.
  12. Llorente JL., et al. “Sinonasal carcinoma: clinical, pathological, genetic and therapeutic advances”. Nature Reviews of Clinical Oncology 8 (2014): 460–472.
  13. Lewis JS and Castro EB. “Cancer of the nasal cavity and paranasal sinuses”. The Journal of Laryngology and Otology 3 (1972): 255-262.
  14. Chan JYK., et al. “Non-nasopharyngeal head and neck lymphoepithelioma-like carcinoma in the United States: a population-based study”. Head and Neck1 (2016): E1294-300.


Citation: Evanthia Chrysomali., et al. “A Case of Sinonasal Lymphoepithelial Carcinoma Presenting as a Palatal Swelling". Acta Scientific Dental Sciences 4.8 (2020): 48-51.


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