Abstract

Introduction and Objectives: Oral submucous fibrosis (OSMF) is a chronic, progressive, and irreversible disease of the oral mucosa. Though numerous modalities have been tried but all are palliative and have no curative value. Pentoxifylline possessing vasorelaxive and antifibrotic properties believed to potentiate the anti-inflammatory, anti-oxidant and immune modulating properties of garlic. So, the present a cross-sectional pilot studywas undertaken to evaluate the efficacy of Garlic in conjunction with pentoxifylline in the management of OSMF. 

Methods: The study consisted of 10 OSMF patients. Pentoxifylline (400 mg) was administered thrice daily along with garlic pearls, 2 pearls; thrice daily. Drugs were administered systemically after food for a duration of 2 months. Patients were evaluated every 15 days for the assessment of clinical parameters, i.e. Burning sensation, reduction in mouth opening, tongue protrusion and cheek flexibility. Pre and post treatment study parameters were measured and compared. The improvement was assessed at the end of the study. 

Results: All the patients were males with the mean age of 26.04 years. Patients exhibited a mean reduction of 95.68% in burning sensation and an increment of 5.37 mm in mouth opening. The cheek flexibility and tongue protrusion also showed significant improvements in the study groups. All the patients showed significant (p > 0.001) improvement in SOD levels following treatment. 

Conclusion: Overall assessment of the all clinico-biochemical parameters showed a significant improvement. Thus, choice of such therapy is beneficial, affordable, easily available and most importantly a non-invasive treatment modality for OSMF.

Keywords: Oral Submucous Fibrosis; Pentoxifylline; Garlic

References

1. Lin HJ and Lin JC. “Treatment of oral submucous fibrosis by collagenase: effects on oral opening and eating function”. Oral Disease 13 (2007): 407-413.
2. Gupta D and Sharma SC. “Oral submucous fibrosis- A new treatment regimen”. Journal of Oral and Maxillofacial Surgery 46 (1988): 830-833.
3. Borle RM and Borle SR. “Management of OSMF: A conservative approach”. Journal of Oral and Maxillofacial Surgery 49 (1991): 788-791.
4. Katharia SK., et al. “The effects of placental extract in management of oral sub-mucous fibrosis”. Indian Journal of Pharmacology 24 (1992): 181-183.
5. Haque MF., et al. “Interferon gamma (IFN-) may reverse oral submucous fibrosis”. Journal of Oral Pathology and Medicine 30 (2001): 12-21.
6. Kumar A., et al. “Efficacy of lycopene in the management of oral submucous fibrosis”. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 103 (2007): 207-213.
7. Nimesh Jain and Rajeshwari G. “Efficacy of garlic in conjunction with pentoxifylline in the management of oral submucous fibrosis - a preliminary study”. IJPSR 7.12 (2016).
8. Gupta MK., et al. “Oral submucous fibrosis - Current Concepts in Etiopathogenesis”. People's Journal of Scientific Research (2008): 39-44.
9. Metkari S., et al. “An estimation of serum malondialdehyde, superoxide dismutase and vitamin A in oral submucous fibrosis and its clinicopathologic correlation”. Journal of Oral and Maxillofacial Pathology 11 (2007): 23-27.
10. Burket’s oral medicine 10^th and 12^th edition diagnosis and treatment.
11. KD Tripathi. Essentials of medical pharmacology 5^th edition.

Citation

Citation: Gaurav., et al. “Efficacy of Garlic in Conjunction with Pentoxifylline in the Management of Oral Submucous Fibrosis - A Cross-Sectional Pilot Study”. Acta Scientific Dental Sciences 4.7 (2020): 154-160.

Copyright

Copyright: © 2020 Gaurav., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.