Abstract

Introduction: A high prevalence of diabetes mellitus and dental caries in Saudi Arabian population is overwhelmingly reported. The aim of the study was to assess the following: 1) clinical findings of PD, BOP, and amount of keratinized tissue present around dental implant and 2) PICF levels of IL-1α, IL-1β, IL-6, and IL-8 in diabetic and non-diabetic partially edentulous Saudi Arabian subjects.

Materials and Methods: Total of 32 partially edentulous subjects, 16 diabetic and 16 non-diabetic, were included in the study. PICF samples were taken from peri-implant sulcus using paper point and PCR essays for IL-1α, IL-1β, IL-6, and IL-8 was performed. Clinical parameters of peri-implant PD, BOP and amount of keratinized tissue were recorded.

Results: Diabetic subjects had more significant BOP than non-diabetic counterparts (p-<0.001). No significant difference was found between diabetic and non-diabetic patients in the amount of keratinized tissue (P < 0.765). A significant high level of IL-6 in diabetic subjects when compared to healthy subjects (P < 0.033). No significant difference between diabetic and non-diabetic subjects in the serum level of IL-1α (P < 0.121), IL-1β (P < 0.171) and IL-8 (P < 0.223). A positive correlation between increased serum level of IL-1α, IL-1β, IL-6 and IL-8 with increased PD was determined.

Conclusion: PD, BOP and PICF IL-6 levels were found to be significantly higher in Saudi Arabian diabetic subjects compared to Saudi non-diabetic subjects. Also, a positive relation found between deep PD and four inflammatory markers which are IL-1α, IL-1β, IL-6 and IL-8.

Keywords: Implant; Diabetes; Peri-Implant Crevicular Fluid; IL-1α; IL-1β; IL-6; IL-8; Diabetic Saudi Arabian

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Citation

Citation: Al-Hezaimi., et al. “Relationship between Inflammation-Related Markers in Peri-Implant Crevicular Fluid and Clinical Parameters in Partially Edentulous Saudi Arabian Diabetic Subjects” Acta Scientific Dental Sciences 4.7 (2020): 101-106.

Copyright

Copyright: © 2020 Al-Hezaimi., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.