Acta Scientific Dental Sciences (ISSN: 2581-4893)

Review Article Abstract Volume 4 Issue 6

Genetics in Dentistry

Sugandha Dadhich and Gargi Jani*

Dental Practitioner, Ahmedabad, Gujarat, India

*Corresponding Author: Gargi Jani, Dental Practitioner, Ahmedabad, Gujarat, India.

Received: March 02, 2020; Published: May 08, 2020



 The article reviews the literature on the genetic aspects of various disorders affecting the oral cavity and highlights the influence of genetics on diseases encountered in routine practice. Understanding the mechanism of a disease at genetic level will help an oral health professional in early intervention and would also help to explain a patient why persons with same environmental and behavioral (oral habits, diet) risks are relatively more predisposed to a certain disease.

Keywords: Genetics; Dentistry; Mutation; Gene



  1. Thesleff I., et al. “Regulation of organogenesis. Common molecular mechanisms regulating the development of teeth and other organs”. The International Journal of Developmental Biology 39 (1995): 35-50.
  2. Thesleff I and Niemen P. “Tooth morphogenesis and cell differentiation”. Current Opinion in Cell Biology 8 (1996): 844-850.
  3. “Abnormalities of tooth morphology”. In: Pathology of the dental hard tissues. Copenhagen: Munksgard (1970): 15-74.
  4. Clayton JM. “Congenital dental anomalies occurring in 3,557 children”. Journal of Dentistry for Children - AAPD 23 (1956): 206-208.
  5. Grahnen H. “Hypodontia in the permanent dentition: a clinical and genetical investigation”. Odont Revy 7 (1956): 1-100.
  6. Eidelman E., et al. “Hypodontia: prevalence amongst Jewish populations of different origin”. American Journal of Physical Anthropology 39 (1973): 129-133.
  7. Bergstrom K. “An orthopantomographic study of hypodontia, supernumeraries, and other anomalies in school children between the ages of 8-9 years: an epidemiological study”. Swedish Dental Journal 1 (1977): 145-157.
  8. Jorgenson RJ. “Clinician’s view of hypodontia”. Journal of the American Dental Association 101 (1980): 283-286.
  9. Gorlin RJ., et al. “Syndromes of the Head and Neck”. New York: Oxford University Press (1990).
  10. Vastardis H., et al. “A human MSX1 homeodomain missense mutation causes selective tooth agenesis”. Nature Genetics 13 (1996): 417-421.
  11. Nieminen P., et al. “Identification of a nonsense mutation in the PAX9 gene in molar oligodontia”. European Journal of Human Genetics 9 (2001): 743-746.
  12. Xiao S., et al. “Dentinogenesis imperfecta 1 with or without progressive hearing loss is associated with distinct mutations in DSPP”. Nature Genetics 27 (2001): 201-204.
  13. Cakan DG., et al. “The genetic basis of dental anomalies and its relation to orthodontics”. European Journal of Dentistry 1 (2013): S143-S147.
  14. Carinci F., et al. “Genetic Risk Assessment of Periodontal Disease during Dental Treatments”. Anneals Forensic Research Analyst 1 (2015): 1011.
  15. Michalowicz BS., et al. “Evidence of a substantial genetic basis for risk of adult periodontitis”. Journal of Periodontology 71 (2000): 1699-1707.
  16. Vijayalakshmi R., et al. “Genetic polymorphisms in periodontal diseases: an overview”. Indian Journal of Dental Research 21 (2010): 568-574.
  17. Michalowicz BS., et al. “Evidence of a substantial genetic basis for risk of adult periodontitis”. Journal of Periodontology 71 (2000): 1699-1707.
  18. Loos BG., et al. “Identification of genetic risk factors for periodontitis and possible mechanisms of action”. Journal of Clinical Periodontology 6 (2005): 159-179.
  19. Bretz WA., et al. “Evidence of a contribution of genetic factors to dental caries risk”. The Journal of Evidence-Based Dental Practice 4 (2003): 185-189.
  20. Vogelstein B and Kinzler KW. “The multistep nature of cancer”. Trends in Genetics 9 (1993): 138-141.
  21. Jurel SK., et al. “Genes and oral cancer”. Indian Journal of Human Genetics1 (2014): 4-9.
  22. Ah-See KW., et al. “An allelotype of squamous carcinoma of the head and neck using microsatellite markers”. Cancer Research 54 (1994): 1617-1621.
  23. Nawroz H., et al. “Allelotype of head and neck squamous cell carcinoma”. Cancer Research 54 (1994): 1152-1155.
  24. Van der Riet P., et al. “Frequent loss of chromosome 9p21-22 early in head and neck cancer progression”. Cancer Research 54 (1994): 1156-1158.
  25. Langdon JD and Partridge M. “Expression of the tumour suppressor gene p53 in oral cancer”. British Journal of Oral and Maxillofacial Surgery30 (1992): 214-220.
  26. Krishna A., et al. “Molecular concept in human oral cancer”. National Journal of Maxillofacial Surgery1 (2015): 9-15.


Citation: Sugandha Dadhich and Gargi Jani. “Genetics in Dentistry”. Acta Scientific Dental Sciences 4.6 (2020): 13-17.


Acceptance rate30%
Acceptance to publication20-30 days
Impact Factor1.278

Indexed In

News and Events

  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is June 25, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

Contact US