Abstract

  The growing scientific interest in the correlation between systemic pathologies and periodontal pathologies, shows how chronic infectious-inflammatory diseases, such as periodontitis, have implications with neurodegenerative pathologies, cause of cognitive decline and deprivation of self-sufficiency in the affected subjects.

  Numerous studies in literature show that pathogenic microorganisms implicated in periodontal disease play an important role in the onset or more likely in the progression of neuro-degenerative diseases.

  The increase in the average age of the population requires increasing commitment in the management of the needs of the "Aging Society".

  The appropriateness of clinical management in preventing and removing universally known periodontal pathogens is fully part of the prevention of systemic diseases that impact on social and public health.

  The minimally invasive "flapless" techniques performed with new-generation instruments represent the preferred approach also for patients presenting polytherapy, guaranteeing them an adequate reduction of the microbial load, a factor which is decisive for oral and systemic health.

Keywords: Oral Microbiota; Alzheimer Disease; Porphyromonas Gingivalis; Gingipain Inhibitor

References

1. Dominy SS., et al. “Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors” Science Advances 5.1 (2019).
2. Viganò L., et al. “The Oral Microbiome in the Context of Aging and Cognitive Impairment” Acta Scientific Microbiology 1.8 (2018).
3. Brennon C.A., et al. “Fusobacterium nucleatum-symbiont, opportunist and oncobacterium” Nature Reviews Microbiology  17.3 (2019): 156-166.
4. Sun CH., et al. “The Role of Fusobacterium nucleatum in colorectal cancer: from carcinogenesis to clinical management” Chronic Diseases and Translational Medicine 5.3 (2019): 178-187. 
5. Asakawa M., et al. “Tongue Microbiota and Oral Health Status in Community-Dwelling Elderly Adults” mSphere 3.4 (2018).
6. Shao J., et al. “Periodontal Disease and Brest Cancer: A Meta-Analysis of 1,73,162 Participants” Frontiers in Oncology 8 (2018): 601. 
7. Viganò L., et al. “Brest Cancer and its Treatment: impact on Oral Health. A Traditional Review” Acta Scientific Microbiology 1.12 (2018).
8. Arastu-Kapur S., et al. “Treatment of Porphyromonas gulae infection and downstream pathology in the aged dog lysine-gingipain inhibitor COR388” Pharmacol Res Perspect. 8.1 (2020). 
9. Singhrao S.K., et al. “Are Porphyromonas gingivalis Outer Membrane Vesicles Microbullets for Sporadic Alzheimer’s Disease Manifestation?” J Alzheimer’s Dis Rep 2.1 (2018): 219-228.
10. Choi S., et al. “Association of Chronic Periodontitis on Alzheimer’s Disease or Vascular Dementia” Journal of The American Geriatrics Society .
11. Petersilka G., et al. “Evalutation of an ex vivo porcine model to investigate the effect of low abrasive airpolishing” Clinical Oral Investigations 22.7 (2018): 2669-2673.
12. Tomasi C., et al. “Factors Influencing the outcome of non-surgical periodontal treatment: A multilevel approach” Journal of Clinical Periodontology 34.8 (2007): 682-690.
13. Singhrao S.K., et al. “Assessing the role of Porphyromonas gingivalis in periodontitis to determine a causative relationship with Alzheimer’s Disease” Journal of Oral Microbiology 11.1 (2019): 1563405. 

Citation

Citation: Monica Giovanna Ravera. “Cognitive Decline and Oral Microbiota. Pro-Inflammatory Conditions Become Risk Factors in Neurodegenerative Disease”. Acta Scientific Dental Sciences 4.3 (2020): 105-109.

Copyright

Copyright: © 2020 Monica Giovanna Ravera. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.