Acta Scientific Dental Sciences (ISSN: 2581-4893)

Research Article Volume 4 Issue 3

Potential Use of Adipose-Derived Mesenchymal Stromal Cells and Bone Graft for Dental Implant: A Systematic Review

Wesley Antonio Galhardo Fornazari1 and Idiberto José Zotarelli Filho2/*

1Fornazari Odontology, Street Prudente de Moraes, Downtown, Novo Horizonte/SP, Brazil
2Zotarelli-Filho Scientific Work, São José do Rio Preto/SP, Brazil

*Corresponding Author: Idiberto José Zotarelli Filho, Zotarelli-Filho Scientific Work, São José do Rio Preto/SP, Brazil.

Received: December 11, 2019; Published: February 21, 2020



Introduction: Over the past 30 years, the number of dental implant procedures has increased worldwide, reaching about one million dental implants per year. In Brazil, in recent decades, there has been a very rapid evolution in implant dentistry with high success rates.

Objective: It was performed a systematic review of the main findings and potential use of adipose-derived stem cell and bone graft for a dental implant. Methods: A total of 55 clinical studies and reviews that were submitted for eligibility analysis were checked, and after that, 38 studies were selected, following the rules of systematic review-PRISMA. The search strategy was performed in PubMed, Embase, Ovid and Cochrane Library, Web of Science, ScienceDirect Journals (Elsevier), Scopus (Elsevier), OneFile (Gale).

Major Findings and Conclusion: Tissue engineering is a tool that allows by means of a suitable biological niche for any construction and regeneration of tissues and organs. Another advantage is minimally invasive surgery or allows the use of surgical techniques that cause less risk to the patient. This condition is maintained because the cells involved in the biological niche secret growth factors for cell proliferation and differentiation and supramolecular structures that ensure the functional organization of tissue generated by means of stereochemistry and its systemic integration ADSCs can potentiate osteogenesis and reduce the possibility of developing bone necrosis. Moreover, the ADSC, when cultured in the presence of bone, releases cytokines osteopoiesis undergo a process that involves the proliferation and maturation of primitive precursor cells to the formation of functional osteoblasts and bone cells originated ADSC this phenomenon is committed osteoprogenitor cells and pre-osteoblasts osteoblasts and osteocytes. Therefore, the lack of bone in the alveolar ridges has been a major problem in functional aesthetic recovery in patients who have suffered dentoalveolar trauma, traumatic tooth extractions, congenitally missing teeth, maxillary and mandibular pathologies. For the filling of large bone defects, the development of bone regeneration improves epithelial barriers to bone graft, favoring dental implantation.

Keywords: Adipose-derived stem cell. Stromal vascular fraction. Platelet-rich plasma. Bone loss. Dental implant.



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Citation: Wesley Antonio Galhardo Fornazari and Idiberto José Zotarelli Filho. “Potential Use of Adipose-Derived Mesenchymal Stromal Cells and Bone Graft for Dental Implant: A Systematic Review”. Acta Scientific Dental Sciences 4.3 (2020): 59-66.


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