Abstract

  Bisphosphonates are synthetic substances of inorganic pyrophosphate that have been based on the treatment of patients with osteolytic diseases, such as multiple myeloma, malignant hypercalcemia, Paget's disease or patients with bone metastases. Its main pharmacological effect is the inhibition of bone resorption caused by osteoclasts, which have their function diminished. Its adverse effects are infrequent, but include pyrexia, kidney function problems, hypocalcemia and, more recently, Maxillomandibular ostenecrosis induced by bofosphonates. This report describes a clinical case of mandibular osteonecrosis induced by bishophonates in a patient with chronic kidney disease and the Therapeutic protocol performed.

Keywords: Osteonecrosis of The Jaws; Bisphosphonates; Chronic Kidney Disease

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Citation

Citation: Kaohana Thaís da Silva., et al. “Osteonecrosis of the Jaws Associated with the Use of Bisphosphonates in A Patient with Chronic Kidney Disease”.Acta Scientific Dental Sciences 4.2 (2020): 82-86.

Copyright

Copyright: © 2020 Kaohana Thaís da Silva., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.