Acta Scientific Dental Sciences (ISSN: 2581-4893)

Case Series Volume 4 Issue 2

Osteonecrosis of the Jaws Associated with the Use of Bisphosphonates in A Patient with Chronic Kidney Disease

Kaohana Thaís da Silva*, Larissa Nicole pasqualotto, Fabiana Seguin and Gadebayo Rabelo de Oliveira

Department of Odontology, Universidade Estadual Do Oeste Do Paraná, Brasil

*Corresponding Author: Kaohana Thaís da Silva, Department of Odontology, Universidade Estadual Do Oeste Do Paraná, Brasil.

Received: August 27, 2019; Published: January 18, 2020



  Bisphosphonates are synthetic substances of inorganic pyrophosphate that have been based on the treatment of patients with osteolytic diseases, such as multiple myeloma, malignant hypercalcemia, Paget's disease or patients with bone metastases. Its main pharmacological effect is the inhibition of bone resorption caused by osteoclasts, which have their function diminished. Its adverse effects are infrequent, but include pyrexia, kidney function problems, hypocalcemia and, more recently, Maxillomandibular ostenecrosis induced by bofosphonates. This report describes a clinical case of mandibular osteonecrosis induced by bishophonates in a patient with chronic kidney disease and the Therapeutic protocol performed.

Keywords: Osteonecrosis of The Jaws; Bisphosphonates; Chronic Kidney Disease



  1. Schiodt M. “Management of Osteonecrosis of the Jaw in Patients Receiving Antiresorptive Treatment”. In: The Duration and Safety of Osteoporosis Treatment. 3th ed. Springer International Publishing. 27 (2016): 193-202.             
  2. Yamamoto FP. “Study of the presence of osteonecrosis in the Madybula after molar extraction in rats treated with alendronate sodium [doctoral thesis]”. São Paulo: University of São Paulo (2010).
  3. Zanata A., et al. “Mandibular osteonecrosis associated with the use of sodium bisphosphonate in a patient with multiple myeloma”. Portuguese Journal of Dental Dentistry and maxillofacial Surgery 55.2 (2014): 115-120.     
  4. Fede D., et al. “Osteonecrosis of the jaws in patients assuming oral bisphosphonates for osteoporosis: a retrospective multi-hospital-based study of 87 Italian cases”. European Journal of Internal Medicine 24 (2013): 784-790.      
  5. Otto S., et al. “Bisphosphonate-related osteonecrosis of the jaw: is pH the missing part in the pathogenesis puzzle?” Journal of Oral and Maxillofacial Surgery 68.5 (2010):1158-1161.
  6. Ruggiero SL., et al. “American Association of Oral and Maxillofacial Surgeons Position Paper on Bisphosphonate‐Related Osteonecrosis of the Jaws – 2009”. Journal of Oral and Maxillofacial Surgery 67.1 (2009): 2-12.
  7. Assael LA. “Oral bisphosphonates as a cause of bisphosphonate‐related osteonecrosis of the jaws: Clinical findings”. Journal of Oral and Maxillofacial Surgery 67.1 (2009): 35-43.           
  8. Medeiros NH., et al. “Chronic renal failure and its interferences in dental care: literature review”. See dental Univ Cid São Paulo 26.3 (2015): 24-28.
  9. Costa-son JZC., et al. “Dental care in patients with chronic renal failure”. Rev Cir Traumatol Buco-Maxilo-FAC 7.2 (2007): 19-28.
  10. Chidambaram R. “Optimal antibiotic dosage for chronic kidney disease patient: a pharmacological manual for oral clinicians”. Recent patents on anti-infective drug Discovery 10.2 (2015): 113-123.


Citation: Kaohana Thaís da Silva., et al. “Osteonecrosis of the Jaws Associated with the Use of Bisphosphonates in A Patient with Chronic Kidney Disease”.Acta Scientific Dental Sciences 4.2 (2020): 82-86.


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