Acta Scientific Dental Sciences

Editorial Volume 1 Issue 1

“Cryotherapy”– A Panacea for Post-Operative Pain Following Endodontic Treatment

Saravana Karthikeyan Balasubramanian1* and Divya Vinayachandran2

1Reader, Department of Conservative Dentistry and Endodontics, SRM Dental College and Hospital, SRM University, Ramapuram, Chennai, Tamil Nadu, India
2 Senior Lecturer, Department of Oral Medicine and Radiology, SRM Kattankulathur Dental College and Hospital, SRM University, Kattankulathur, Chennai, Tamil Nadu, India

*Corresponding Author: Saravana Karthikeyan Balasubramanian, Reader, Department of Conservative Dentistry and Endodontics, SRM Dental College and Hospital, SRM University, Ramapuram, Chennai, Tamil Nadu, India.

Received: May 21, 2017; Published: June 01, 2017

Citation: Saravana Karthikeyan Balasubramanian and Divya Vinayachandran. ““Cryotherapy”– A Panacea for Post-Operative Pain Following Endodontic Treatment”. Acta Scientific Dental Sciences 1.1 (2017).

  The main rationale of endodontic treatment is to eliminate micro-organisms from the infected root canal system by an adequate chemo mechanical debridement followed by a three dimensional obturation to achieve a hermetic seal, thereby to provide a conducive environment for periradicular healing. However, even with the utmost care in performing a root canal therapy, some patients experience pain or flare ups following the treatment. This post-endodontic pain is an unpleasant yet unfortunately, a common sensation encountered in a clinical scenario which may affect the quality of patient-doctor relationship [1]. The incidence of this post endodontic pain (PEP) was reported to range from 3 - 58% [2]. Pak and White concluded that the prevalence of PEP was 40% at 24 hours, whereas it reduced to 11% at 1 week and it was most intense in the first six hours following a gradual decline after a week [3,4].

  The various reasons attributing to PEP are many-fold which include the condition of the pulp and periradicular tissues, microbial factors, the effects of inflammatory chemical mediators, immune system mediated phenomena, cyclic nucleotide changes, patients’ psychological factors, preoperative pain, gender, type of tooth involved, and changes in the local adaptation and the periapical tissue pressure [5,6]. In addition, inadequate root canal instrumentation, hyper-occlusion, failure to recognize additional/accessory canals, presence of periapical pathology, extrusion of apical debris, and apical patency during canal preparation also contribute to the occurrence of PEP [7]. Irritants affecting the periapical tissues that can evoke pain sensations include several irrigating solutions or medicaments employed during root canal therapy [5]. Whilst this pain may be due to an acute inflammatory response in the periradicular tissues, pain in itself is a poor indicator of pathology and is considered an unreliable predictor for long term success. Hence, the integral part of endodontic treatment must include prevention and management of this post endodontic pain.

  However, this PEP can be prevented in clinical situations by adapting meticulous careful measures during the endodontic treatment procedure. Each clinical step of root canal therapy (RCT) must be done with utmost perfection, some examples include, accurate working length (WL) determination, proper cleaning and shaping (crown down technique) with adequate sequencing of instruments, optimum use and judicious selection of intracanal irrigants, and use of magnifying devices, such as dental loupes and endodontic microscopes [8,9]. The use of a negative apical pressure irrigation device can also result in a significant reduction of post endodontic pain levels in comparison to conventional needle irrigation [10]. Several other strategies which have been developed for PEP management include premedication with prophylactic analgesics and corticosteroids prior to endodontic treatment, administration of long-lasting anaesthesia, and occlusal reduction [11-15].

  Cryotherapy is a long-standing therapeutic technique that has been frequently applied in sports injuries and surgical procedures for pain management and postoperative care in the field of medicine [16,17]. Cryotherapy has been reported to be effective at reducing oedema, pain, inflammation and recovery time with shortterm applications in orthopaedic, abdominal, gynaecological and hernia operations [17-20]. The term cryotherapy is derived from the Greek word cryos, meaning “cold”. Though, it refers to lowering or decreasing the tissue temperature for therapeutic purposes, cryotherapy actually does not imply implementing cold but rather extracting heat [21]. The magnitude of the change in temperature and biophysical alterations in the tissues depend upon the differences in the temperature of the object and the heat or cold application, exposure time, thermal conductivity of the tissues, and type of the heat or cold agents employed. The clinical implication of this type of therapy in human tissues causes changes in the host’s local temperature [22].

  The basic physiological responses following the application of either heat or cold are: i) increase or decrease in local blood flow, ii) stimulation or inhibition of neural receptors in the skin and subcutaneous tissues, and iii) an increase or decrease in cellular metabolic activity [23]. Physiological and clinical evidence suggest that cold therapy, in different forms, may reduce musculo-skeletal pain, muscular spasm, connective tissue distension, nerve conductivity time, haemorrhage and inflammation [21,23]. According to Van’t Hoff’s law, cryotherapy causes vasoconstriction and slows down cellular metabolism by limiting biochemical reactions which minimize the degree of tissue damage, thereby reducing the oxygen demand of cells and limiting the production of free radicals in tissues [24,25]. Vasoconstriction produces antiedema effects, and pain reduction is achieved after temperature reduction because of blockade of the nerve endings resulted from cold application [26]. The intensity of the vasoconstriction effect reaches the highest value at a temperature of 15°C [26] and it has been reported that lowering the body temperature decreases peripheral nerve conduction, and in particular, when it reaches about 7°C there is complete deactivation of myelinated A-δ fibres whereas deactivation of nonmyelinated C-fibre occurs at about 3°C, as proved by Franz and Iggo [27]. Also, changes in tissue pressure activates pain receptors called as thermoreceptors, i.e. temperature-sensitive nerve endings. Cryotherapy activates these thermoreceptors, thereby blocking nociception within the spinal cord [24]. Nociceptors are specialised nerve endings which are activated following a tissue injury. Therefore, the analgesic effect resulting from cryotherapy is mainly produced by a combination of a decreased release of inflammatory chemical mediators of pain and a slower conduction of neural pain signals.

  In dentistry, cold application has been frequently employed for postoperative pain control following intraoral surgical procedures [28]. Though, mechanism of action and effectiveness of cryotherapy is well addressed in the literature [17,22], strong evidence to support its conclusions is lacking, besides standardisation of crucial factors such as the time period, duration, application mode and cold agent used. However, in recent years, few studies have attempted and reported the intracanal use of cryotherapy in endodontics to reduce post endodontic pain [29-31]. For instance, Vera., et al. (2016) reported in an in vitro study that, cold saline solution (2.5°C) when employed as a final irrigant for 5 mins, resulted in reduction of external root surface temperature by more than 10°C and maintained for 4 mins, which may be enough to produce a local anti-inflammatory effect in periradicular tissues [29]. But, the first clinical study on the effect of intracanal cryotherapy in endodontics was conducted by C Keskin., et al. (2016) who assessed the effect of 2.5°C cold saline irrigation as a final irrigant following biomechanical preparation of root canals on postoperative pain in patients with irreversible pulpitis and, reported that, there was a significant pain reduction levels when compared to that of a control group [30]. In this study, the authors compared the effect of intracanal cryotherapy by delivering the cold saline solution using conventional needle irrigation with side-vented 31 G NaviTip needle inserted 2 mm short from working length, during the root canal treatment of all patients. However, a recent clinical study by Al-Nahlawi., et al. (2016) revealed the effects of intracanal cryotherapy and negative irrigation technique (EndoVAc System) on post endodontic pain after vital single visit endodontic treatment [31]. According to the results of this significant study, intracanal cryotherapy along with negative pressure irrigation system reduced PEP and resulted in elimination of post endodontic pain clinically [31].

  Hence, in light of these observations, intracanal cryotherapy can be considered as a simple, cost-effective, and non-toxic therapeutic treatment option for postoperative pain control in single visit RCT cases. However, numerous research studies should be conducted in the near future to investigate the possible benefits of this technique in the treatment of other pulpal and periradicular diseases. In addition, the investigation of inflammatory markers amongst patients subjected to intracanal cryotherapy might shed a further light on the action mechanism and the potential use of cryotherapy in endodontics [30].


  1. Rosenberg PA. “Clinical strategies for managing endodontic pain”. Endodontic Topics 3 (2002): 78-92
  2. Sathorn C.,et al. “The prevalence of postoperative pain and flare- up in single-visit and multiple-visit endodontic treatment: a systematic review”. International Endodontic Journal 41.2 (2008): 91-99.
  3. Pak JG and White SN. “Pain Prevalence and severity before, during, and after root canal treatment: a systematic review”. Journal of Endodontics 37.4 (2011): 429-438.
  4. Alonso-Ezpeleta LO.,et al. “Postoperative pain after one-visit root-canal treatment on teeth with vital pulps: Comparison of three different obturation technique”. Medicina Oral, Patologia Oral, Cirugia Bucal 17.4 (2012): e721-e727.
  5. Seltzer S. “Pain in endodontics”. Journal of Endodontics 30.7(2004): 501-503.
  6. Ali A.,et al. “Influence of preoperative pain intensity on postoperative pain after root canal treatment: a prospective clinical study”. Journal of Dentistry 45 (2016): 39-42.
  7. Alves Vde O. “Endodontic flare-ups: a prospective study”. Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontics110.5 (2010): e68-e72.
  8. Daniel, JG. “Advanced endodontics for clinicians”. 1st ed. Bangalore:J and J Publication; (1998): 202-208.
  9. Bystrom A and Sundqvist G. “The antibacterial action of sodium hypochlorite and EDTA in 60 cases of endodontic therapy”. International Endodontic Journal 18.1 (1985): 35-40.
  10. Rubinstein R.,et al. “Microscopes in endodontics”. Dental Clinics of North America 41 (1997): 29-40.
  11. Attar S.,et al. “Evaluation of pretreatment analgesia and endodontic treatment for postoperative endodontic pain”. Journal of Endodontics 34.6 (2008): 652-655.
  12. Pochapski MT.,et al. “Effect of pretreatment dexamethasone on postendodontic pain”. Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontics 108.5 (2009): 790-795.
  13. Parirokh M.,et al. “Effect of bupivacaine on postoperative pain for inferior alveolar nerve block anesthesia after single-visit root canal treatment in teeth with irreversible pulpitis”. Journal of Endodontics 38.8 (2012): 1035-1039.
  14. Dina Al-Sudani.,et al. “Incidence and intensivity of postoperative pain and periapical inflammation after endodontic treatment with two different instrumentation techniques”. European Journal of Inflammation 10.1 (2012): 99-103.
  15. Parirokh M.,et al. “Effect of occlusal reduction on postoperative pain in teeth with irreversible pulpitis and mild tenderness to percussion”. Journal of Endodontics 39.1 (2013): 1-5.
  16. Swenson C.,et al. “Cryotherapy in sports medicine”. Scandinavian Journal of Medicine and Science in Sports 6.4 (1996): 193- 200.
  17. Watkins AA.,et al. “Ice packs reduce postoperative midline incision pain and narcotic use: a randomized controlled trial”. Journal of American College of Surgeons 219.3 (2014): 511-517.
  18. Kwekkeboom KL. “Pain management strategies used by patients with breast and gynecologic cancer with postoperative pain”. Cancer Nursing 24.5 (2001): 378-386.
  19. McDowell JH.,et al. “Use of cryotherapy for orthopaedic patients”.Orthopedic Nursing 13.5 (1994): 21-30.
  20. Koc M.,et al. “Cooling for the reduction of postoperative pain:prospective randomized study”. Hernia: The Journal of Hernias and Abdominal Wall Surgery 10.2 (2006): 184-186.
  21. Belitsky RB.,et al. “Evaluation of the effectiveness of wet ice,dry ice, and cryogenic packs in reducing skin temperature”.Physical Therapy 67.7 (1987): 1080-1084.
  22. Hubbard TJ and Denegar CR. “Does cryotherapy improve outcomes with soft tissue injury?” Journal of Athletic Training 39.3 (2004): 278-279.
  23. Knight KL. “Cryotherapy in sports injury management”. Champaign, IL: Human Kinetics (1995): 60.
  24. Nadler SF.,et al. “The physiologic basis and clinical applications of cryotherapy and thermotherapy for the pain practitioner”. Pain Physician 7.3 (2004): 395-400.
  25. Muldoon J. “Skin cooling, pain and chronic wound healing progression”. British Journal of Community Nursing 11.3 (2006): 21-25.
  26. Modabber., et al. “Three- dimensional evaluation of postoperative swelling in treatment of zygomatic bone fractures using two different cooling therapy methods: a randomized, observer-blind, prospective study”. Trials 14 (2013): 238.
  27. Franz DN and Iggo A. “Conduction failure in myelinated and non-myelinated axons at low temperatures”. The Journal of Physiology 199.2 (1968): 319-345.
  28. Laureano Filho JR.,et al. “The influence of cryotherapy on reduction of swelling, pain and trismus after third-molar extraction: a preliminary study”. Journal of the American Dental Association 136.6 (2005): 774-778.
  29. Vera J.,et al. “Effect of intracanal cryotherapy on reducing root surface temperature”. Journal of Endodontics 41.11 (2015): 1884-1887.
  30. Cangul Keskin.,et al. “Effect of intracanal cryotherapy on pain after single visit root canal treatment”. Australian Endodontic Journal 42 (2016): 9-11.
  31. Al-Nahlawi T.,et al. “Effect of Intracanal Cryotherapy and Negative Irrigation Technique on Post endodontic Pain”. Journal of Contemporary Dental Practice 17.12 (2016): 990-996.

Copyright: © 2017 Saravana Karthikeyan Balasubramanian and Divya Vinayachandran. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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