Acta Scientific Cardiovascular System

Research Article Volume 1 Issue 6

Sinus Variability in Patients Followed for Stroke at the Yaounde Central and General Hospitals

Valérie Ndobo-Koé1,2*, Chris-Nadège Nganou-Gnindjio1,2, Dieudonné Danwe1, Leonard Ngarka1,2, Ronni Coyan Tankeu1, Almamy Aboubakar Djalloh4,5, Kemnang Yemele Honoré1, Siddikatou Djibrilla6,7, Hamadou Ba5 and Alain Patrick Menanga1,3

1Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Cameroon
2Yaoundé Central Hospital, Yaoundé, Cameroon
3Yaoundé General Hospital, Cameroon
4Cite-Verte District hospital, Cameroon
5Faculty of Medicine and Biomedical Sciences, University of Garoua, Cameroon
6Faculty of Medicine and Biomedical Sciences, University of Buea, Cameroon
7Douala Laquintinie Hospital, Cameroon

*Corresponding Author: Valérie Ndobo-Koé, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Cameroon.

Received: October 20, 2022; Published: October 28, 2022



Introduction: Stroke remains a pandemic that affects one person every 5 seconds. It is the second leading cause of death worldwide from non-communicable diseases. In Cameroon, half of neurology consultations with a mortality of up to 76% in patients hospitalized in intensive care. It is suggested that cardiovascular mortality linked to stroke is induced by neurological stress and disturbances of the Heart-brain axis via dysfunctions of the autonomic nervous system. Heart Rate Variability (HRV) is a non-invasive method used to assess the coordination of the autonomic nervous system over the sinus node.

Objective: Determine the values of sinus variability and the factors associated with its alteration in patients followed for cerebrovascular accident (CVA).Methods: We conducted a cross-sectional study between June and August 2021 in two hospitals in the city of Yaoundé. We included adult patients followed for stroke and who gave their informed consent. We excluded those without a sinus rhythm and those whose Holter-ECG recording was uninterpretable. Sinus variability was determined by time analysis and Holter spectral analysis - 24h ECG.

Results: In total, we included 40 patients in the study, including 25 men (65%). The average age was 64 ± 15 years. Two thirds of the participants had an ischemic stroke and the majority of them had a mild stroke according to the NIHSS score. The median SDNN was 71.0 ms, SDAN 73.3 ms, median RMSSD 49.6, and median PNN50 4.91%. After spectral analysis, the median LF was 97.8 ms2, the median HF 106.6 ms2 and the median LH/FH ratio 0.86. None of the factors studied was associated with the decrease in sinus variability.

Conclusion: This study suggests a significant decrease in sinus variability and an alteration in sympathovagal balance in subjects who have suffered a stroke in Cameroon. 

Keywords: Sinus Variability; Stroke; Yaoundé



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Citation: Valérie Ndobo-Koé.et al. “Sinus Variability in Patients Followed for Stroke at the Yaounde Central and General Hospitals". Acta Scientific Cardiovascular System 1.6 (2022): 27-31.

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