Tejwir Grewal1, Arunkumar Gunasekaran1 and Manish Kapoor2*
1Senior Resident, Department of Cardiology, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Mawdiangdiang, Shillong, Meghalaya, India
2Associate Professor, Department of Cardiology, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Mawdiangdiang, Shillong, Meghalaya, India
*Corresponding Author: Manish Kapoor, Associate Professor, Department of Cardiology, North Eastern Indira Gandhi Regional Institute of Health And Medical Sciences, Mawdiangdiang, Shillong, Meghalaya, India.
Received: September 29, 2021; Published: November 01, 2021
Objectives: Routine biomarkers used to diagnose acute coronary syndrome are undetectable in considerable number of patients especially in early stage of ACS. Early stages ACS involves platelet activation hence change in platelet morphology leading to increase in PDW. Here we aimed to study the diagnostic importance of PDW in acute coronary syndrome.
Materials and Methods: A hospital based case-control study was conducted in the period between February 2019 to February 2020. 77 cases and 77 controls satisfying the inclusion and exclusion criteria and having given an informed consent to participate in the study were included in the study. All consecutive patients presenting with the chest pain of < 24 hours duration with ECG changes consistent with ACS with/without raised cardiac biomarkers were taken as cases and age, sex matched non ACS patients were taken as controls. In both groups platelet count and PDW were measured.
Results: The mean age of the cases enrolled in the study was 56.81 + 12.86 years and controls enrolled in the study was 56.19 + 12.35 years (p = 0.764). The mean left ventricular ejection fraction (LVEF) was significantly lower in case arm compared to control arm (46.51 + 5.83 Vs 59.32 + 1.70; p < 0.001). In comparison to control group the case arm had lower platelet count (207.81 + 34.29 × 107/L Vs 226.60 + 50.44 × 107/L; p = 0.008) and higher platelet distribution width (17.45 + 2.57 fL Vs 16.58 + 2.44 fL; p = 0.033). The area under the receiver operative curve was used as a predictor of ACS and it showed that the PDW cut-off value of 17.8 fL, the sensitivity and specificity of PDW in diagnosing acute coronary syndrome was found 84.4% and 53.2%, respectively.
Conclusion: Our data indicate that both high PDW and low platelet count are early indicators of ACS and it can be used with other cardiac biomarkers for early diagnosis of ACS. It is relatively cheaper, easily available and complementary to other tests used in the patients presenting with chest pain in emergency room.
Keywords: Acute Coronary Syndrome; Platelet Count; Platelet Distribution Width; Diagnosis; Marker
Citation: Manish Kapoor., et al. “A Study of the Diagnostic Importance of Platelet Distribution Width in Acute Coronary Syndrome". Acta Scientific Cardiovascular System 1.1 (2021): 01-06.
Copyright: © 2021 Manish Kapoor., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.