Acta Scientific Clinical Case Reports

Case Report Volume 3 Issue 1

Urothelial Carcinoma Medley with Diversity and Heterogeneity: A Rare Case Report

Vidhya Manohar*

Department of histopathology, University College London Hospitals NHS Trust, London, United Kingdom

*Corresponding Author: Vidhya Manohar, Department of histopathology, University College London Hospitals NHS Trust, London, United Kingdom.

Received: November 16, 2021; Published: December 24, 2021

Abstract

Urothelial carcinoma is well recognised to show morphological plasticity and differentiation to variant morphological types and heterologous components. Some variants are rare, but some of the subtypes have shown definite implications in prognosis with an aggressive course. The current WHO classification has not only reiterated its importance but has also provided clarification and definite factual points for better categorisation. The advent of recent diagnostic tools and tailored therapeutic implications has further validated the classification. The accurate recognition is vital and a poses real challenge to the pathologist in this scenario. We present to you a case of high-grade urothelial carcinoma with diverse and varied differentiation including small cell neuroendocrine carcinoma, adenocarcinoma and sarcomatoid carcinoma with rhabdomyosarcoma and chondrosarcoma as heterologous components.

Keywords: Urothelial Carcinoma; Plasticity; Heterogeneity

References

  1. Amin MB. “Histological variants of urothelial carcinoma: diagnostic, therapeutic and prognostic implications”. Modern Pathology2 (2009): S96-S118.
  2. Humphrey PA., et al. “The WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part B: Prostate and Bladder Tumours”. European Urology1 (2016): 106-119.
  3. Lobo N., et al. “What Is the Significance of Variant Histology in Urothelial Carcinoma?” European Urology Focus 4 (2020): 653-663.
  4. Veskimäe E., et al. “Cancer guidelines panel systematic review”. European Urology Oncology 6 (2019): 625-642.

Citation

Citation: Vidhya Manohar. “Urothelial Carcinoma Medley with Diversity and Heterogeneity: A Rare Case Report". Acta Scientific Clinical Case Reports 3.1 (2022): 53-54.

Copyright

Copyright: © 2022 Vidhya Manohar. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




Metrics

Acceptance rate30%
Acceptance to publication20-30 days
Impact Factor1.057

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